Results 81 to 90 of about 343,812 (340)

Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlCl₃ Toxicity in Rats

Toxics, 2023
Jambolan fruit extract and choline were investigated for Aluminum tri chloride (AlCl3)-induced Alzheimer’s disease in rats. Thirty-six male “Sprague Dawley” rats weighing (150 ± 10 g) were allocated into six groups; the first group was fed a baseline ...
Zeinab Abdel Salam Hawash, Ensaf M. Yassien, Badriyah S. Alotaibi, Amira M. El-Moslemany, Mustafa Shukry   +4 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Effects of Monovalent and Divalent Cations on Ca2+ Fluxes Across Chromaffin Secretory Membrane Vesicles [PDF]

, 1983
: Bovine chromaffin secretory vesicle ghosts loaded with Na+ were found to take up Ca2+ when incubated in K+ media or in sucrose media containing micromolar concentrations of free Ca2+. Li+- or choline+loaded ghosts did not take up Ca2+.
Baker P. F., Borle A. B., Carafoli E., Flodgaard H., Goldstone T. P., Heidemarie I. Krieger-Brauer, Kostron H., Lowry O. H., Manfred Gratzl, Phillips J. H., Reed K. C., Saermark T., Sandeaux R., Sillen L. G.   +13 more
core   +1 more source

Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats

Diabetology
Background: Choline (Ch) deprivation causes kidney injury and dysfunction, and diabetic nephropathy is also known to be a complication of diabetes; thus, this interplay could potentially aggravate diabetic kidney disease.
Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi   +6 more
doaj   +1 more source

LC–MS/MS Analysis of Choline Compounds in Japanese-Cultivated Vegetables and Fruits

Foods, 2020
Choline is an essential nutrient and choline esters are potential functional food ingredients. We aimed to analyze the choline compound content in 19 cultivated fruits and vegetables and identify those with high acetylcholine content.
Wenhao Wang, Shohei Yamaguchi, Masahiro Koyama, Su Tian, Aya Ino, Koji Miyatake, Kozo Nakamura   +6 more
doaj   +1 more source

Neuroprotective Actions of Dietary Choline

Nutrients, 2017
Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor S-adenosylmethionine.
J. Blusztajn, B. Slack, Tiffany J Mellott   +2 more
semanticscholar   +1 more source

Imaging of Lipid Droplets in Living Cells and Mice with Metabolic Dysfunction‐Associated Steatotic Liver Disease via a Galactose‐Modified Supramolecular Near‐Infrared Fluorescent Glycoprobe

Advanced Functional Materials, EarlyView.
A galactose‐modified supramolecular near‐infrared (NIR) glycoprobe, TCF‐FBN@Gal‐BSA, enables targeted delivery to the liver through the asialoglycoprotein receptor (ASGPR) and facilitates liver‐targeting fluorescence visualization of lipid droplets (LDs) in metabolic dysfunction‐associated steatotic liver disease (MASLD) mice.
Han‐Min Wang, Lei Dong, Qiu‐Lian Hao, Lu‐Lu Sun, Xin‐Rong Li, Yu‐Wei Yuan, Ming‐Ye Tang, Jin Gong, Yi Zang, Jia Li, Tony D. James, Xiao‐Peng He, Hai‐Hao Han   +12 more
wiley   +1 more source

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V, Sharpton, Suzanne R, Terrault, Norah A, Yong, Germaine JM   +3 more
core   +1 more source

Performance, Egg Quality, and Yolk Antioxidant Capacity of the Laying Quail in Response to Dietary Choline Levels

Animals, 2022
The current study determined the ideal dose of choline in the diet of laying quails based on egg development, egg quality, and antioxidant capacity. A total of 120 female quails (244.7 ± 10.38 g) were randomly assigned to 6 experimental groups with 5 ...
Osman Olgun, Esra Tuğçe Gül, Gözde Kılınç, Alpönder Yıldız, Abdullah Çolak, Ainhoa Sarmiento-García   +5 more
doaj   +1 more source

Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Alcoholism: Clinical and Experimental Research, 2018
BACKGROUND We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy.
S. Jacobson, R. C. Carter, C. Molteno, Mark E. Stanton, Jane S. Herbert, Nadine M. Lindinger, Catherine E. Lewis, Neil C. Dodge, H. Hoyme, S. Zeisel, E. Meintjes, Christopher P. Duggan, J. Jacobson   +12 more
semanticscholar   +1 more source