Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis [PDF]
Nature Communications, 2023 Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic choline. However,
Ryutaro Tamura +19 more
doaj +5 more sources
Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology [PDF]
Asian-Australasian Journal of Animal Sciences, 2018 Objective The study was designed to establish choline deficiency model (CDM) in broilers for evaluating efficacy of polyherbal formulation (PHF) in comparison with synthetic choline chloride (SCC).
Ramasamy Selvam +4 more
doaj +5 more sources
A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors. [PDF]
PLoS ONE, 2017 The liver and intestine are susceptible to the oxidative damage which could result in several diseases. Choline deficiency induced oxidative damage in rat liver cells.
Pei Wu +7 more
doaj +4 more sources
Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis. [PDF]
J Food Drug Anal, 2018 Phyllanthus emblica L. fruit contains abundant bioactive components and exhibits a variety of biological activities. In this study, the hepatoprotective effect of water extract of P.
Tung YT, Huang CZ, Lin JH, Yen GC.
europepmc +3 more sources
Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice [PDF]
Journal of Obesity, 2012 Previous studies demonstrated that choline supply is directly linked to high-fat-diet-induced obesity and insulin resistance in mice. The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a ...
Gengshu Wu +5 more
doaj +3 more sources
Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency. [PDF]
PLoS ONE, 2017 Serum levels of choline and its derivatives are lower in patients with inflammatory bowel disease (IBD) than in healthy individuals. However, the effect of choline deficiency on the severity of colitis has not been investigated.
Shintaro Sagami +9 more
doaj +4 more sources
Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet. [PDF]
PLoS ONE, 2015 Few studies have evaluated the impact of dietary choline on the health and well-being of swine, and those pivotal papers were aimed at determining dietary requirements for sows and growing pigs.
Caitlyn M Getty, Ryan N Dilger
doaj +3 more sources
Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats [PDF]
The Scientific World Journal, 2014 Betaine is an important natural component of rich food sources, especially spinach. Rats were fed diets with betaine or spinach powder at the same level of betaine for 10 days to investigate the dose-dependent effects of spinach powder supplementation on
Yi-Qun Liu +8 more
doaj +3 more sources
Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice. [PDF]
Nutrients, 2021 Folate and choline are interconnected metabolically. The MTHFD1 R653Q SNP is a risk factor for birth defects and there are concerns that choline deficiency may interact with this SNP and exacerbate health risks.
Christensen KE +7 more
europepmc +2 more sources
Severe choline deficiency induces alternative splicing aberrance in optimized duck primary hepatocyte cultures [PDF]
Animal Bioscience, 2022 Objective Choline deficiency, one main trigger for nonalcoholic fatty liver disease (NAFLD), is closely related to lipid metabolism disorder. Previous study in a choline-deficient model has largely focused on gene expression rather than gene structure ...
Lulu Zhao +5 more
doaj +2 more sources