Results 51 to 60 of about 1,083,054 (280)

Requirement of phosphatidylcholine for normal progression through the cell cycle in C3H/10T1/2 fibroblasts.

Journal of Lipid Research, 1994
We have investigated the possible requirement of phosphatidylcholine for normal progression through the cell cycle of C3H/10T1/2 fibroblasts. Incubation of the cells in a medium with 0.5% serum synchronized the cells in the G0 stage of the cell cycle ...
F Tercé, H Brun, D E Vance
doaj   +1 more source

Inflammation and the pathological progression of Alzheimer’s disease are associated with low circulating choline levels

Acta Neuropathologica, 2023
Deficiency of dietary choline, an essential nutrient, is observed worldwide, with ~ 90% of Americans being deficient. Previous work highlights a relationship between decreased choline intake and an increased risk for cognitive decline and Alzheimer’s ...
Jessica M Judd, Paniz Jasbi, W. Winslow, G. Serrano, T. Beach, J. Klein-Seetharaman, R. Velazquez   +6 more
semanticscholar   +1 more source

Direct Gravity‐Induced Modulation of Cardiac Conduction Pathways Evidenced Through Propagation Features in Electrophysiological Mapping

Advanced Materials Technologies, EarlyView.
A high‐density wearable body‐surface potential mapping array reveals how gravity reshapes cardiac conduction in real time. By resolving spatiotemporal delay patterns invisible to conventional ECG, the platform uncovers posture‐dependent electrophysiological adaptations across the thorax.
Ruben Ruiz‐Mateos Serrano, Matias L. Picchio, Daniele Mantione, David Mecerreyes, George G. Malliaras   +4 more
wiley   +1 more source

Modulation of liver cholesterol homeostasis by choline supplementation during fibrosis resolution

Heliyon
Liver fibrosis is a critical global health challenge, often leading to severe liver diseases without timely intervention. Choline deficiency has been linked to metabolic dysfunction associated steatohepatitis (MASH) and liver fibrosis, suggesting choline
Eiko Saijou, Yoshiko Kamiya, Katsunori Fujiki, Katsuhiko Shirahige, Ryuichiro Nakato   +4 more
doaj   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Serum lipids in choline-deficient male and female rats

Journal of Lipid Research, 1964
Serum lipids from normal and choline-deficient male and female rats were fractionated on silicic acid. Total cholesterol, phosphorus, and fatty acid compositions were determined on serum cholesterol esters, triglycerides, phospholipids, and a small mixed
J. Tinoco, Angela Shannon, Richard L. Lyman   +2 more
doaj   +1 more source

Scientific Opinion on the substantiation of a health claim related to choline and "development of brain" pursuant to Article 14 of Regulation (EC) No 1924/2006 [PDF]

EFSA Journal, 2014
Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products ...
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Folate and choline: does it take two to tango in early programming of disease?

Lifestyle Genomics, 2023
Background: The early life period marks a critical time during which the health trajectory of offspring can be shaped by external influences including maternal nutrition. Folate and choline are water-soluble micronutrients important for fetal development
Vicki Chen, Jacob L. Schwartz, Clara E. Cho   +2 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source