Results 1 to 10 of about 286,434 (357)

Monitoring the Right Collection: The Central Cholinergic Neurons as an Instructive Example

Frontiers in Neural Circuits, 2017
Some neurons are more equal than others: neuroscience relies heavily on the notion that there is a division of labor among different subtypes of brain cells.
Balázs Hangya, Katalin Sviatkó, Katalin Sviatkó   +2 more
doaj   +1 more source

State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. [PDF]

, 2019
Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition ...
Garcia-Junco-Clemente, Pablo, Ringach, Dario L, Trachtenberg, Joshua T, Tring, Elaine   +3 more
core   +1 more source

New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

Molecules
Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation.
Violina T. Angelova, Boris P. Stoyanov, Rumyana Simeonova   +2 more
doaj   +1 more source

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

Frontiers in Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with abnormal protein modification, inflammation and memory impairment. Aggregated amyloid beta (Aβ) and phosphorylated tau proteins are medical diagnostic features.
Sumonto Mitra, Homira Behbahani, Maria Eriksdotter, Maria Eriksdotter   +3 more
doaj   +1 more source

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. [PDF]

, 2019
Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine
Angelopoulos, CM, Bartakova, AB, Daneman, R, Goldberg, JL, Murphy, A, Nudleman, E, Pulido, RS, Shah, SH, Weiner, GA   +8 more
core   +1 more source

Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons

Frontiers in Cell and Developmental Biology
TRPM4 is a calcium activated non-selective cation channel, impermeable to Ca2+, in neurons it has been implicated in the regulation of the excitability and in the persistent firing.
Paula Leyton, Denise Riquelme, Francisco A. Peralta, Franco D. Navarro, Elias Leiva-Salcedo   +4 more
doaj   +1 more source

Effects of scopolamine on matching to sample paradigm and related tests in human subjects [PDF]

, 2003
This was a double-blind placebo-controlled study with a cross-over design to examine the effects of scopolamine on cognitive functions in young healthy subjects.
Adam, M., Engel, R., Kathmann, N., Koller, G., Satzger, W., Soyka, Michael, Wagner, M.   +6 more
core   +1 more source

The Binding and Effects of Boron-Containing Compounds on G Protein-Coupled Receptors: A Scoping Review

Receptors
Boron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana, Alina Barquet-Nieto, Bhaskar C. Das, Rafael Barrientos-López, Melvin N. Rosalez, Ruth M. Lopez-Mayorga, Marvin A. Soriano-Ursúa   +6 more
doaj   +1 more source

Neurochemical substrates and neuroanatomical generators of the event-related P300 [PDF]

, 1999
The present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as ...
Bottlender, Ronald, Frodl-Bauch, Thomas, Hegerl, Ulrich   +2 more
core   +1 more source

Association of cholinergic biomarkers with postoperative delirium in elderly patients undergoing regional anesthesia - An observational study

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Postoperative delirium (POD) is a prevalent and serious complication in elderly patients undergoing surgery, contributing to prolonged hospital stays and increased morbidity.
Praveen Kumar Yadav, Shefali Gautam, Jyotsna Agrawal, Neel Kamal Mishra, Vinod Kumar Srivastava, Shashank Kanaujia, Rajesh Raman, Mohammad Kaleem Ahmad   +7 more
doaj   +1 more source