Results 101 to 110 of about 169,479 (311)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Activity-Dependent Changes in Cholinergic Innervation of the Mouse Olfactory Bulb

, 2011
Ernesto Salcedo, Nhat-Tuan Tran, Xuan Ly, Robert Lopez, Cortney Barbica, Diego Restrepo, Sukumar Vijayaraghavan   +6 more
openalex   +2 more sources

Cholinergic imbalance in the multiple sclerosis hippocampus [PDF]

, 2011
Evert‐Jan Kooi, Marloes Prins, Natasha Bajic, Jeroen A.M. Beliën, Wouter H. Gerritsen, Jack van Horssen, Eleonora Aronica, Anne‐Marie van Dam, Jeroen J.M. Hoozemans, Paul T. Francis, Paul van der Valk, Jeroen J.G. Geurts   +11 more
openalex   +1 more source

Genetics of infertility and “assisted fertilization” in the Bible: The case of Abraham and his family

Andrology, EarlyView.
Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni, Frank Tüttelmann, Livio Casarini   +2 more
wiley   +1 more source

Demonstration of a Simple Epitope Tag Multimerization Strategy for Enhancing the Sensitivity of Protein Detection Using Drosophila vAChT

G3: Genes, Genomes, Genetics, 2020
Kole V. Tison, Hannah M. McKinney, R. Steven Stowers   +2 more
doaj   +1 more source

Endogenous Cholinergic Inputs and Local Circuit Mechanisms Govern the Phasic Mesolimbic Dopamine Response to Nicotine

, 2013
Michael Graupner, Reinoud Maex, Boris Gutkin   +2 more
openalex   +2 more sources

Roles of M₂and M₃muscarinic receptors in cholinergic nerve‐induced contractions in mouse ileum studied with receptor knockout mice [PDF]

, 2006
Tomonori Unno, Hayato Matsuyama, Y. IZUMI, Maki Yamada, Jürgen Wess, S. Komori   +5 more
openalex   +1 more source

Review for "Human wildtype tau expression in cholinergic pedunculopontine tegmental neurons is sufficient to produce PSP‐like behavioural deficits and neuropathology"

, 2021
Antonis Asiminas
openalex   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source