Results 21 to 30 of about 167,062 (267)

Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease

Frontiers in Pharmacology, 2019
This Mini Review discusses the merits and shortfalls of transgenic (tg) rodents modeling aspects of the human Alzheimer’s disease (AD) pathology and their application to evaluate experimental therapeutics.
A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, Hélène Hall, Sonia Do Carmo   +4 more
doaj   +1 more source

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons

Translational Psychiatry
Genome wide association and animal studies have implicated genetic variations in CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5*nAChRs), as a risk factor for developing alcohol use disorders (AUDs).
Léa Tochon, Nadia Henkous, Morgane Besson, Uwe Maskos, Vincent David   +4 more
doaj   +1 more source

Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is a common age-related neurodegenerative disorder that is characterized by progressive cognitive decline. The deficits in cognition and attentional processing that are observed clinically in AD are linked to impaired function of
Leah K. Cuddy, Leah K. Cuddy, Leah K. Cuddy, Claudia Seah, Stephen H. Pasternak, Stephen H. Pasternak, R. Jane Rylett, R. Jane Rylett   +7 more
doaj   +1 more source

Adaptive short‐term associative conditioning in the pancreatic β‐cell

Physiological Reports, 2020
This study associates cholinergic stimulation of the pancreatic β‐cell electrical activity with a short‐term memory phenomenon. Glucose pulses applied to a basal glucose concentration induce depolarizing waves which are used to estimate the evolution of ...
Juan V. Sanchez‐Andres, Raquel Pomares, Willy J. Malaisse   +2 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis

Frontiers in Immunology, 2017
The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans.
Donald B. Hoover, Donald B. Hoover, Thomas Christopher Brown, Madeleine K. Miller, John B. Schweitzer, John B. Schweitzer, David L. Williams, David L. Williams   +7 more
doaj   +1 more source

Progress of research on delaying bone destruction of rheumatoid arthritis by combining traditional Chinese and Western medicine

Advanced Chinese Medicine, EarlyView.
Abstract Rheumatoid arthritis (RA) is a common autoimmune disease with bone destruction as the core pathology, which belongs to the category of “impediment disease” in traditional Chinese medicine (TCM), and its etiology and pathogenesis are still not completely clear.
Dier Jin, Yuanyuan Xu, Wenwen Qi, Tianyi Lan, Ting Liu, Rihong Liu, Zihan Wang, Yuan Xu   +7 more
wiley   +1 more source

Alzheimer’s Disease: Current and Future Treatments. A Review

International Journal of Medical Students, 2014
Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder whose treatment poses a big challenge. Proposed causes of AD include the cholinergic, amyloid and tau hypotheses.
Evelyn Chou
doaj   +1 more source

Cholinergic-Induced Specific Oscillations in the Medial Prefrontal Cortex to Reverse Propofol Anesthesia

Frontiers in Neuroscience, 2021
General anesthesia is a drug-induced reversible state comprised of altered states of consciousness, amnesia, analgesia, and immobility. The medial frontal cortex (mPFC) has been discovered to modulate the level of consciousness through cholinergic and ...
Lieju Wang, Weijie Zhang, Ying Wu, Yibo Gao, Na Sun, Hao Ding, Jinxuan Ren, Lina Yu, Liangliang Wang, Fen Yang, Wang Xi, Wang Xi, Min Yan   +12 more
doaj   +1 more source

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source