Results 21 to 30 of about 169,479 (311)

Central Cholinergic Nervous System and Cholinergic Agents [PDF]

Acta Medica (Hradec Kralove, Czech Republic), 1998
Central cholinergic nervous system play important role in many physiological and behavioral functions in humans. The activity of the cholinergic nervous system depends upon the production and fate of acetylcholine and all compounds influenced its biosynthesis, storage, release, hydrolysis, interaction with different subtypes of cholinergic receptors ...
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Cyclosporine in Cholinergic Itch

Indian Dermatology Online Journal, 2022
Cholinergic itch is part of symptom complex that also includes cholinergic erythema and cholinergic urticaria. It mostly occurs during the winters among young adults. It is characterized by onset of severe itching or burning sensation all over body, mostly, on exposure to sunlight, warm atmosphere and in some cases after hot ...
Sumit Sehgal, Vanshika Arora, Lalit Gupta, Ashok Kumar Khare, Kapil Vyas, Asit Mittal   +5 more
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The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions

Frontiers in Immunology, 2020
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking exhibit time-dependent ...
Andrés García-García, Simón Méndez-Ferrer, Simón Méndez-Ferrer, Simón Méndez-Ferrer   +3 more
doaj   +1 more source

Alzheimer’s Disease, Hearing Loss, and Deviance Detection

Frontiers in Neuroscience, 2022
Age-related hearing loss is a widespread condition among the elderly, affecting communication and social participation. Given its high incidence, it is not unusual that individuals suffering from age-related hearing loss also suffer from other age ...
David Pérez-González, David Pérez-González, Thomas G. Schreiner, Thomas G. Schreiner, Daniel A. Llano, Daniel A. Llano, Daniel A. Llano, Manuel S. Malmierca, Manuel S. Malmierca, Manuel S. Malmierca   +9 more
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Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease

Frontiers in Pharmacology, 2019
This Mini Review discusses the merits and shortfalls of transgenic (tg) rodents modeling aspects of the human Alzheimer’s disease (AD) pathology and their application to evaluate experimental therapeutics.
A. Claudio Cuello, A. Claudio Cuello, A. Claudio Cuello, Hélène Hall, Sonia Do Carmo   +4 more
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A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild‐to‐moderate Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day.
Pradeep J. Nathan, S. Babli Millais, Alex Godwood, Odile Dewit, David M. Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T. Maruff, Gregory A. Light, Alastair J.H. Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker   +14 more
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Diuretic and Natriuretic Effects of Hesperidin, a Flavanone Glycoside, in Female and Male Hypertensive Rats

Plants, 2022
Hesperidin (HSP) is a major flavanone glycoside in citrus fruits, including sweet oranges and lemons. It demonstrates numerous pharmacological activities, such as antihypertensive effects and cardiac and kidney tissue protection.
Priscila de Souza, Rita de Cássia Vilhena da Silva, Luisa Nathália Bolda Mariano, Sabrina Lucietti Dick, Giovana Cardozo Ventura, Valdir Cechinel-Filho   +5 more
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SYMPATHETIC POSTGANGLIONIC CHOLINERGIC FIBRES [PDF]

British Journal of Pharmacology, 1960
When the postganglionic fibres to the nictitating membrane are stimulated in a cat treated with reserpine, the membrane contracts. The contraction is increased after the injection of eserine and is abolished with atropine. Thus the fibres stimulated appear to be cholinergic.
J H, BURN, M J, RAND
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Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons

Translational Psychiatry
Genome wide association and animal studies have implicated genetic variations in CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5*nAChRs), as a risk factor for developing alcohol use disorders (AUDs).
Léa Tochon, Nadia Henkous, Morgane Besson, Uwe Maskos, Vincent David   +4 more
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Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is a common age-related neurodegenerative disorder that is characterized by progressive cognitive decline. The deficits in cognition and attentional processing that are observed clinically in AD are linked to impaired function of
Leah K. Cuddy, Leah K. Cuddy, Leah K. Cuddy, Claudia Seah, Stephen H. Pasternak, Stephen H. Pasternak, R. Jane Rylett, R. Jane Rylett   +7 more
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