Results 61 to 70 of about 167,062 (267)
Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk +3 more
wiley +1 more source
A brief review on the mode of action of antinematodal drugs
Acta Veterinaria, 2017 Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites.
Abongwa Melanie +2 more
doaj +1 more source
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen +4 more
wiley +1 more source
ReceptorsBoron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana +6 more
doaj +1 more source
The Input-Output Relationship of the Cholinergic Basal Forebrain
Cell Reports, 2017 Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different cortical areas and timescales ...
Matthew R. Gielow, Laszlo Zaborszky
doaj +1 more source
Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density
Clinical Anatomy, EarlyView.ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones +7 more
wiley +1 more source
Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil
Chemistry &Biodiversity, EarlyView.ABSTRACT In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry.
Angela Palma Amorin +8 more
wiley +1 more source
Role of cholinergic innervation and RGS2 in atrial arrhythmia
Frontiers in Physiology, 2012 The heart receives both sympathetic and parasympathetic efferent innervation as well as having the ability to process information internally via an intrinsic cardiac autonomic nervous system (ICANS).
DOUGLAS L. JONES +2 more
doaj +1 more source
Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro [PDF]
, 2022 Christopher A. Simon +4 more
openalex +1 more source
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT Background Nicotine has been associated with cognitive functions such as memory and attention, with serum neurofilament light chain (sNfL) as a biomarker for neurological diseases such as Alzheimer's disease (AD) and multiple sclerosis (MS).
Qianqian Ji +5 more
wiley +1 more source