Results 41 to 50 of about 28,548 (243)

Duration of Antimuscarinic Administration for Treatment of Overactive Bladder Before Which One Can Assess Efficacy: An Analysis of Predictive Factors [PDF]

open access: yesInternational Neurourology Journal, 2015
Purpose: To determine the duration of antimuscarinic therapy for overactive bladder syndrome (OAB) appropriate for assessment of the efficacy of treatment, and to evaluate the possible predictive factors for response to therapy. Methods: All OAB patients
Sheng-Mou Hsiao   +3 more
doaj   +1 more source

TRPV1 receptor antagonist blunts cholinergic‐mediated sweating

open access: yesThe FASEB Journal, 2018
Cholinergic‐mediated primary sweat production requires an increase in Ca ++ influx across the epithelial cell membrane of the sweat gland. Several Ca ++ channels have been proposed to contribute to the increase in Ca ++
Gary W. Mack, Kevin R. Kunz
openaire   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

open access: yesAdvanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang   +15 more
wiley   +1 more source

Effects of Terazosin and Tolterodine on Ureteral Stent Related Symptoms: A Double-Blind Placebo-Controlled Randomized Clinical Trial

open access: yesInternational Brazilian Journal of Urology, 2013
Objective To evaluate the effects of terazosin and tolterodine on ureteral stent discomfort. Materials and Methods Of 163 patients assessed for eligibility, 104 patients were randomly assigned to receive placebo, 2 mg of terazosin twice daily, 2 mg of ...
Ali Tehranchi   +3 more
doaj   +1 more source

Precision modulation of tumor excitability: Targeting cell phenotypic heterogeneity for next‐generation cancer therapy

open access: yesBMEMat, EarlyView.
This Perspective introduces tumor electrical excitability as a previously overlooked dimension of cancer biology. It proposes that tumor–neural interactions enable malignant cells to acquire neuron‐like properties and form bidirectional chemical and electrical communications with nerves.
Zonghao Liu   +9 more
wiley   +1 more source

Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.

open access: yesPLoS ONE, 2011
The neurotransmitter glutamate is released by excitatory projection neurons throughout the brain. However, non-glutamatergic cells, including cholinergic and monoaminergic neurons, express markers that suggest that they are also capable of vesicular ...
Michael J Higley   +8 more
doaj   +1 more source

Hippocampus and Entorhinal Cortex Recruit Cholinergic and NMDA Receptors Separately to Generate Hippocampal Theta Oscillations

open access: yesCell Reports, 2017
Summary: Although much progress has been made in understanding type II theta rhythm generation under urethane anesthesia, less is known about the mechanisms underlying type I theta generation during active exploration.
Zhenglin Gu   +3 more
doaj   +1 more source

Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017.

open access: yesPLoS ONE, 2020
ObjectiveTo evaluate the prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017.MethodsA descriptive analysis using pharmacy prescription data was conducted.
Lingyan Yu   +3 more
doaj   +1 more source

The Efficacy of Lacosamide in the Treatment of Delirium Complicated With Ileus: Four Cases. [PDF]

open access: yesNeuropsychopharmacol Rep
Delirium in elderly patients is difficult to treat when complicated by ileus. This report describes three cases of antipsychotic‐induced paralytic ileus successfully managed with lacosamide without severe adverse effects. Lacosamide's pharmacological profile suggests it may be a safe treatment option for delirium tremens in older patients.
Sato S.
europepmc   +2 more sources

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing   +4 more
wiley   +1 more source

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