Results 181 to 190 of about 126,705 (239)

Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19. [PDF]

Med Hypotheses, 2020
Pomara N, Imbimbo BP.
europepmc   +1 more source

Integrin αMβ2 as a Key Regulator of the Anti-Inflammatory Cholinergic Response in Macrophages and Neutrophils.

Inflammation underlies numerous diseases, including sepsis, rheumatoid arthritis, atherosclerosis, and diabetes, representing a significant global health burden where current anti-inflammatory therapies often prove insufficient.
Casteel, Jared
core  

tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
Experimental design and key findings. Four groups (Control+Sham, Control+tVNS, LPS+Sham, LPS+tVNS; n = 7 each) underwent serum ELISA, brain Western blot, and behavioral testing. tVNS altered serum Haptoglobin, IL‐6, CGRP1, and VE‐Cadherin levels, reversed LPS‐induced increases in brain IL‐1β, HMGB1, Haptoglobin, PAR‐2, and CGRP, and alleviated LPS ...
Kerem Atalar, Ece Alim, Aysen Calikusu, Elif Gulcicek Abbasoglu Topa, Hale Gok Dagidir, Meltem Bahcelioglu, Neslihan Bukan, Fusun Erten, Kazım Sahin, Saadet Özen Akarca Dizakar, Hayrunnisa Bolay   +10 more
wiley   +1 more source

Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, Volume 17, Issue 6, Page 1034-1042, June 2026.
Hypothyroidism is an independent risk factor for cognitive impairment in T2DM patients, with a progressive risk increase associated with higher TSH levels. These findings underscore the importance of integrating thyroid function evaluation into the cognitive assessment and management strategy for this patient population.
Mengmeng Zheng, Xing Zhong, Ping Zhang
wiley   +1 more source

COVID-19 induced ARDS, and the use of galantamine to activate the cholinergic anti-inflammatory pathway. [PDF]

Med Hypotheses, 2020
Ahmad F.
europepmc   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Parasympathetic overdrive as a cause of overactive bladder in a high‐fat‐diet‐induced obesity mouse model

The Journal of Physiology, Volume 604, Issue 12, Page 4945-4967, 15 June 2026.
Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +3 more
wiley   +1 more source

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

Feasibility of Therapeutic Effects of the Cholinergic Anti-Inflammatory Pathway on COVID-19 Symptoms. [PDF]

J Neuroimmune Pharmacol, 2020
Mazloom R.
europepmc   +1 more source

Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis. [PDF]

Mediators Inflamm, 2020
Li HB, Zhou Y, Zhao AH, Guo LL.
europepmc   +1 more source