Results 181 to 190 of about 3,652,668 (207)
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Cholinergic anti-inflammatory pathway in intracerebral hemorrhage
Brain Research, 2010Stimulated vagus nerve excretes acetylcholine into the peripheral immune organs such as the spleen, reducing innate inflammation. Here, we investigated whether activation of this "cholinergic anti-inflammatory pathway" can be used to reduce cerebral inflammation in a model of hemorrhagic stroke.
Lee, ST Lee, Soon-Tae +9 more
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The Effect of the Cholinergic Anti‐Inflammatory Pathway on Experimental Colitis
Scandinavian Journal of Immunology, 2007AbstractInflammatory bowel diseases (IBD) are characterized by proinflammatory cytokines, tissue damage and loss of neuron in inflamed mucosa, which implies the cholinergic anti‐inflammatory pathway may be destroyed during the process of inflammatory response.
A, Bai, Y, Guo, N, Lu
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Controlling inflammation: the cholinergic anti-inflammatory pathway
Biochemical Society Transactions, 2006Innate immune responses and inflammation are regulated in part by neural mechanisms. In the present paper, we summarize experimental evidence that reveals that innate immunity and inflammation are controlled by the vagus nerve, previously known as a regulator of other vital physiological functions.
V A, Pavlov, K J, Tracey
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Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway
Journal of Endotoxin Research, 2003The innate immune system is activated by infection and injury to release pro-inflammatory cytokines, which activate macrophages and neutrophils and modulate specific cellular responses. The magnitude of the cytokine response is critical, because a deficient response may result in secondary infections, while an excessive response may be more injurious ...
Christopher J, Czura +2 more
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Acute Vagotomy Activates the Cholinergic Anti-Inflammatory Pathway
American Journal of Physiology-Heart and Circulatory Physiology, 2005Within minutes of acute myocardial infarction (MI), proinflammatory cytokines increase in the brain, heart, and plasma. We hypothesized that cardiac afferent nerves stimulated by myocardial injury signal the brain to increase central cytokines. Urethane-anesthetized male Sprague-Dawley rats underwent ligation of the left anterior descending coronary ...
van Westerloo, David, van der Poll, Tom
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MicroRNA: Novel Modulators of the Cholinergic Anti-Inflammatory Pathway
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2013MicroRNAs (miRNAs) have emerged as key gene regulators controlling the expression of many target mRNAs. The nervous system harbors highest number of miRNAs expressed in a spatially and temporally controlled manner.
Medha, Priyadarshini +5 more
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Neuroscience and Biobehavioral Reviews, 2017
Acetylcholine (ACh), as a classical neurotransmitter, regulates the neuronal network in response to internal and external stimuli. In recent decades, the biology of ACh has been endowed with unparalleled new insights, especially with respect to cholinergic anti-inflammatory properties in non-neuronal cells.
Bin Han, Junwei Hao
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Acetylcholine (ACh), as a classical neurotransmitter, regulates the neuronal network in response to internal and external stimuli. In recent decades, the biology of ACh has been endowed with unparalleled new insights, especially with respect to cholinergic anti-inflammatory properties in non-neuronal cells.
Bin Han, Junwei Hao
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The Role of α7nAChR-Mediated Cholinergic Anti-inflammatory Pathway in Immune Cells
Inflammation, 2021Alpha 7 nicotinic acetylcholine receptor (α7nAChR) is widely distributed in the nervous and non-cholinergic immune systems. It is necessary for the cholinergic transmitter to participate in the regulation of inflammatory response and is the key element of cholinergic anti-inflammatory pathway (CAP).
Yi-jin Wu +5 more
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Current Medicinal Chemistry, 2011
Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP)
M, Pohanka +7 more
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Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP)
M, Pohanka +7 more
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The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body
2006As reviewed above, there is abundant evidence implicating autonomic dysfunction or cytokine excess in diseases with inflammatory pathology such as sepsis, Crohn’s disease, and rheumatoid arthritis. The identification of a vagus nerve mechanism that regulates cytokine activity and immune cell activation now suggests that some neurological or nervous ...
C. J. Czura +2 more
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