Results 211 to 220 of about 85,202 (263)
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The development of cholinergic neurons
Brain Research Reviews, 1988Motoneuron precursors acquire some principles of their spatial organization early in their cell lineage, probably at the blastula stage. A predisposition to the cholinergic phenotype in motoneurons and some neural crest cells is detectable at the gastrula to neurula stages. Cholinergic expression is evident upon cessation of cell division.
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Antibodies to Cholinergic Neurons in Alzheimer's Disease
Journal of Neurochemistry, 1988Abstract: Alzheimer's disease (AD) is associated with degenerative changes in nuclei of the basal forebrain which provide most of the cholinergic input to the cortex and hippocampus and with a reduction in presynaptic cholinergic parameters in these areas.
Joab Chapman +2 more
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The cholinergic neuronal phenotype in alzheimer′s disease
Metabolic Brain Disease, 2000The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene.
J K, Blusztajn, B, Berse
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Cholinergic and non-cholinergic neurons in the rat pedunculopontine tegmental nucleus
Anatomy and Embryology, 1992Choline acetyltransferase immunhistochemistry was employed at light and electron microscopic levels in order to determine the distribution of cholinergic neurons in two subdivisions of the rat pedunculopontine tegmental nucleus that were previously defined on cytoarchitectonic grounds, and to compare the synaptic inputs to cholinergic and non ...
B M, Spann, I, Grofova
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The cholinergic system in aging and neuronal degeneration
Behavioural Brain Research, 2011The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic projections to the cerebral cortex and hippocampus. The cholinergic neurons of this complex have been assumed to undergo moderate degenerative changes during aging, resulting in ...
Reinhard, Schliebs, Thomas, Arendt
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Cholinergic modulation of the cortical neuronal network
Pflügers Archiv - European Journal of Physiology, 2003Acetylcholine (ACh) is an important neurotransmitter of the CNS that binds both nicotinic and muscarinic receptors to exert its action. However, the mechanisms underlying the effects of cholinergic receptors have still not been completely elucidated.
Lucas-Meunier, Estelle +3 more
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Cholinergic neurons in the rat nodose ganglia
Neuroscience Letters, 1987Presence of acetylcholine (ACh) in the vagal afferent fibres of the rat was investigated. In the nodose ganglion, which contains the cell bodies of this sensitive contingent, a choline acetyltransferase (ChAT) activity, a choline (Ch) uptake and an endogenous content of acetylcholine were detected.
B, Palouzier +3 more
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The biochemistry of the cholinergic neurone
Trends in Biochemical Sciences, 1976The cholinergic electromotor system of the electric ray, Torpedo marmorata , provides a hypertrophied version of the normal motor nerves supplying the muscles which simplifies the biochemical study of cholinergic transmission. The mechanism of storage and release of acetylcholine from the presynaptic nerve terminal and the interaction of the ...
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The effect of cobrotoxin on cholinergic neurons in the mouse
Life Sciences, 1992By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent cobrotoxin (CT) and the activity of ...
R, Chen, S E, Robinson
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Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS
1986Considerable information regarding the distribution of cholinergic neurons in the mammalian central nervous system has now been accumulated. This is due to the development of reliable markers for these cells. The most significant one is immunohistochemical staining for choline acetyltransferase (ChAT), the enzyme for acetylcholine synthesis.
P. L. McGeer +3 more
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