Results 191 to 200 of about 85,202 (263)

Selenium-Enriched E. coli Bacteria Mitigate the Age-Associated Degeneration of Cholinergic Neurons in C. elegans. [PDF]

Antioxidants (Basel)
Zytner P, Kutschbach A, Gong W, Ohse VA, Taudte L, Kipp AP, Klotz LO, Priebs J, Steinbrenner H.   +8 more
europepmc   +1 more source

Cancer Neuroscience: From Hallmark‐Enabling Biology to a Therapeutic Pillar

Advanced Oncology, Volume 1, Issue 1, December 2026.
Moran Amit
wiley   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, Volume 13, Issue 55, 5 October 2026.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Histamine H₁ receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice. [PDF]

Nat Commun
Cheng L, Xiao L, Lin W, Li M, Liu J, Qiu X, Li M, Zheng Y, Xu C, Wang Y, Chen Z.   +10 more
europepmc   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, Volume 13, Issue 57, 14 October 2026.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. [PDF]

Neurobiol Aging
Gautier MK, Kelley CM, Lee SH, Mufson EJ, Ginsberg SD.   +4 more
europepmc   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

Longitudinal associations of rapid eye movement (REM) sleep and slow‐wave sleep with plasma Alzheimer's disease biomarkers

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Data on how sleep architecture relates to progression of plasma Alzheimer's disease biomarkers remains limited. METHODS Sixty‐four cognitively unimpaired older adults (ages 55–90) underwent plasma collection twice 2.6 years apart and polysomnography proximate to the first plasma collection.
Jeongyeon Hwang, Luisa F. Figueredo, Daphne I. Valencia, Thomas M. Tolbert, Eriko Hamada, Li Zhou, Joshua L. Gills, Joaquin Ruiz, Katarina R. Martillo, Sarah S. Chu, Ankita Kumar, Esther M. Blessing, Omonigho M. Bubu, Ankit Parekh, Korey Kam, Anna E. Mullins, David M. Rapoport, Indu Ayappa, Ricardo S. Osorio, Andrew W. Varga   +19 more
wiley   +1 more source