Results 21 to 30 of about 124,021 (305)
Cholinergic signaling exerts protective effects in models of sympathetic hyperactivity-induced cardiac dysfunction. [PDF]
PLoS ONE, 2014 Cholinergic control of the heart is exerted by two distinct branches; the autonomic component represented by the parasympathetic nervous system, and the recently described non-neuronal cardiomyocyte cholinergic machinery. Previous evidence has shown that
Mariana Gavioli +14 more
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Cholinergic Signaling, Neural Excitability, and Epilepsy
Molecules, 2021 Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission ...
Yu Wang, Bei Tan, Yi Wang, Zhong Chen
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Characterization of Channelrhodopsin and Archaerhodopsin in Cholinergic Neurons of Cre-Lox Transgenic Mice. [PDF]
PLoS ONE, 2016 The study of cholinergic signaling in the mammalian CNS has been greatly facilitated by the advent of mouse lines that permit the expression of reporter proteins, such as opsins, in cholinergic neurons. However, the expression of opsins could potentially
Tristan Hedrick +7 more
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Cholinergic connectivity: it’s implications for psychiatric disorders.
Frontiers in Cellular Neuroscience, 2013 Acetylcholine has been implicated in both the pathophysiology and treatment of a number of psychiatric disorders, with most of the data related to its role and therapeutic potential focussing on schizophrenia.
Elizabeth eScarr +9 more
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Acetylcholine modulates the temporal dynamics of human theta oscillations during memory
Nature Communications, 2023 The cholinergic system is essential for memory. While degradation of cholinergic pathways characterizes memory-related disorders such as Alzheimer’s disease, the neurophysiological mechanisms linking the cholinergic system to human memory remain unknown.
Tamara Gedankien +6 more
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Potential revival of cholinesterase inhibitors as drugs in veterinary medicine
Frontiers in Veterinary Science, 2023 The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič +3 more
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Neurobiology of Disease, 2011 Vascular cognitive impairment has been related to dysfunction of the central cholinergic system. Studies exploring the putative relationship between vascular cognitive impairment and cholinergic dysfunction have largely been aimed at symptomatic ...
Erik I. Hoff +6 more
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66108 Central Cholinergic Synapse Formation in Optimized Primary Septal “Hippocampal Co” cultures
Journal of Clinical and Translational Science, 2021 IMPACT: Optimization of primary septal-hippocampal co-cultures facilitates studying central cholinergic synapse formation and dysfunction OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and memory and ...
Sarra Djemil +4 more
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Complete morphologies of basal forebrain cholinergic neurons in the mouse
eLife, 2014 The basal forebrain cholinergic system modulates neuronal excitability and vascular tone throughout the cerebral cortex and hippocampus. This system is severely affected in Alzheimer's disease (AD), and drug treatment to enhance cholinergic signaling is ...
Hao Wu, John Williams, Jeremy Nathans
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European Journal of Histochemistry, 2021 Several cholinergic regions have been detected in the brainstem of mammals. In general, these regions are constant among different species, and the nuclear complement is maintained in animals belonging to the same order.
Pilar Marcos, Rafael Coveñas
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