Results 91 to 100 of about 2,823,581 (316)
Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
Molecules, 2018 A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green +2 more
semanticscholar +1 more source
Medications used in dementia: a review of evidence
Sri Lanka Journal of Psychiatry, 2015 Background Dementia is an acquired global impairment of intellect, memory and personality, without impairment of consciousness. It is usually progressive in nature. The management of dementia is mainly two faceted; pharmacological and non-pharmacological.
C. Suraweera, R. Hanwella, V.A. de Silva
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Visual hallucinations (VHs) are a common feature of Parkinson's disease (PD) believed to arise from disruptions to the functional architecture supporting sensory integration and attentional control. Across synucleinopathies, increased pathological burden in the amygdala and deficits in cholinergic modulation have been linked to VHs.
Anna Ignatavicius +6 more
wiley +1 more source
ACCUMULATION OF ACETYLCHOLINE IN BRAIN AND BLOOD OF ANIMALS POISONED WITH CHOLINESTERASE INHIBITORS [PDF]
, 1952 W. C. Stewart
openalex +1 more source
The choroid plexus water density
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose To quantify normative ranges and circadian variability of the choroid plexus (ChP) water density in healthy adults. Methods Actigraphy assessments of circadian activity were performed for 5 days in healthy participants (n = 15; age = 28.5 ± 6.5 years) and subsequently participants underwent repeated, high spatial resolution proton ...
Abigail R. Dubois +8 more
wiley +1 more source
Open Medicine, 2015 Background: Cholinesterase inhibitors and glutamate blockers are commonly used for the treatment of cognitive impairment in Alzheimer’s disease. The aim was to evaluate the effects of rivastigmine and memantine alone or in combination in rats with ...
Yanev Peter Georgiev +2 more
doaj +1 more source
THE PRODUCTION OF BLOCK AND AURICULAR FIBRILLATION IN THE HEART-LUNG PREPARATION BY INHIBITORS OF CHOLINESTERASE [PDF]
, 1955 J. H. Burn +2 more
openalex +1 more source
ChemistryOpen, EarlyView.The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi +8 more
wiley +1 more source