Results 101 to 110 of about 2,781,261 (274)

Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species

ChemistryOpen, EarlyView.
The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi, Gokhan Zengin, Mehmet Veysi Cetiz, Zoltán Cziáky, József Jeko, Muammer Bahşi, Uğur Çakılcıoğlu, Halbay Turumtay, Abdurrahman Aktumsek   +8 more
wiley   +1 more source

In Silico Prediction and Validation of LmGt Inhibitors Using QSAR and Molecular Docking Approaches [PDF]

Proceedings of the 2025 IEEE International Conference on Innovation in Computing and Engineering (ICE), Greater Noida, India, pp. 1 to 5, 2025
Leishmaniasis caused by Leishmania mexicana relies on Leishmania mexicana gluscose transporter (LmGT) receptors, which play an important role in glucose and ribose uptake at different stages of parasite's life cycle. Previous efforts to identify LmGT inhibitors have been primarily based on in vitro screening.
arxiv   +1 more source

Relationship of the revised anticholinergic drug scale with cultured cell‐based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Objective The Anticholinergic Drug Scale (ADS) is a commonly used measure of anticholinergic exposure. This study describes an expanded and revised version of the ADS (rADS) and its relationship with cultured cell‐based serum anticholinergic activity (cSAA) and cognitive measures.
Ryan M. Carnahan, Susmita Chandramouleeshwaran, Naba Ahsan, Roger Raymond, Jose N. Nobrega, Wei Wang, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista L. Lanctôt, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji   +14 more
wiley   +1 more source

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +1 more source

Phytocomponents and evaluation of acetylcholinesterase inhibition by Ginkgo biloba L. leaves extract depending on vegetation period

CyTA - Journal of Food, 2020
Leaves of the Ginkgo biloba L. have been identified as a source of bioactive compounds and their consumption may lead to the improvement of the brain function.
Joanna Kobus-Cisowska, Marcin Dziedziński, Oskar Szczepaniak, Weronika Kusek, Dominik Kmiecik, Marta Ligaj, Aleksandra Telichowska, Szymon Byczkiewicz, Piotr Szulc, Dominik Szwajgier   +9 more
doaj   +1 more source

Design of a folding inhibitor of the HIV-1 Protease [PDF]

arXiv, 2004
Being HIV-1-PR an essential enzyme in the viral life cycle, its inhibition can control AIDS. Because the folding of single domain proteins, like HIV-1-PR is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved amino acids) which have evolved over myriads of generations to recognize and ...
arxiv  

Prediction of Novel CXCR7 Inhibitors Using QSAR Modeling and Validation via Molecular Docking [PDF]

2024 First International Conference for Women in Computing (InCoWoCo), Pune, India, 2024, pp. 1-5
CXCR7, a G-protein-coupled chemokine receptor, has recently emerged as a key player in cancer progression, particularly in driving angiogenesis and metastasis. Despite its significance, currently, few effective inhibitors exist for targeting this receptor.
arxiv   +1 more source

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Molecules, 2018
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green, Marina Y. Fosso, S. Garneau‐Tsodikova   +2 more
semanticscholar   +1 more source

Stroke Mimicking Thalamotomy in Primary Familial Brain Calcification

Movement Disorders Clinical Practice, EarlyView.
Jaakko Kungshamn, Emma Ottela, Olli Likitalo, Anna Brück, Juho Joutsa   +4 more
wiley   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, EarlyView.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source