Results 121 to 130 of about 2,781,261 (274)

Aging‐Associated Liver Sinusoidal Endothelial Cells Dysfunction Aggravates the Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease

Aging Cell, Volume 24, Issue 5, May 2025.
Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai, Quratul Ain, Navodita Seth, Hongchuan Zhao, Michael Rooney, Alexander Zipprich   +5 more
wiley   +1 more source

Effects of rivastigmine and memantine alone and in combination on learning and memory in rats with scopolamine-induced amnesia

Open Medicine, 2015
Background: Cholinesterase inhibitors and glutamate blockers are commonly used for the treatment of cognitive impairment in Alzheimer’s disease. The aim was to evaluate the effects of rivastigmine and memantine alone or in combination in rats with ...
Yanev Peter Georgiev, Dimitrova Darinka Slavcheva, Getova-Spassova Damianka Peteva   +2 more
doaj   +1 more source

InhibiDistilbert: Knowledge Distillation for a ReLU and Addition-based Transformer [PDF]

arXiv
This work explores optimizing transformer-based language models by integrating model compression techniques with inhibitor attention, a novel alternative attention mechanism. Inhibitor attention employs Manhattan distances and ReLU activations instead of the matrix multiplications and softmax activation of the conventional scaled dot-product attention.
arxiv  

Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis

International Journal of Neuropsychopharmacology, 2015
Background: We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies.
S. Matsunaga, T. Kishi, I. Yasue, N. Iwata   +3 more
semanticscholar   +1 more source

THE PRODUCTION OF BLOCK AND AURICULAR FIBRILLATION IN THE HEART-LUNG PREPARATION BY INHIBITORS OF CHOLINESTERASE [PDF]

, 1955
J. H. Burn, E. M. Vaughan Williams, John M. Walker   +2 more
openalex   +1 more source

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex

Brain Pathology, Volume 35, Issue 3, May 2025.
This study analyzes four public transcriptome datasets from AD patients and age‐matched controls, revealing that the transcriptomic profile in female controls closely resembles that of AD patients. We identified a co‐expressed gene module associated with AD, sex, and aging, enriched with immune‐related functions.
Huiying Wen, Youzhe He, Yuanchun Tang, Langjian Zhu, Quyuan Tao, Bufan Jin, Ting Luo, Yujie Peng, Yanrong Wei, Junjie Lei, Lifang Wang, Fan Wang, Fei Ling, Yue Gao, Lei Han   +14 more
wiley   +1 more source

Non-Adaptive Group Testing with Inhibitors [PDF]

arXiv, 2014
Group testing with inhibitors (GTI) introduced by Farach at al. is studied in this paper. There are three types of items, $d$ defectives, $r$ inhibitors and $n-d-r$ normal items in a population of $n$ items. The presence of any inhibitor in a test can prevent the expression of a defective. For this model, we propose a probabilistic non-adaptive pooling
arxiv  

The comparative efficacy and safety of cholinesterase inhibitors in patients with mild‐to‐moderate Alzheimer's disease: a Bayesian network meta‐analysis

International Journal of Geriatric Psychiatry, 2015
Comparative evidence for efficacy and safety of second‐generation cholinesterase inhibitors (ChEIs) is still sparse.
Hisanori Kobayashi, T. Ohnishi, R. Nakagawa, K. Yoshizawa   +3 more
semanticscholar   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

Measuring What Matters in Parkinson's Disease Research and Dysphagia: The Need for Core Outcome Sets

Movement Disorders, EarlyView.
Margaret Walshe, Julia Hirschwald, Tobias Warnecke   +2 more
wiley   +1 more source