Results 181 to 190 of about 2,823,581 (316)

Type‐Specific Single‐Neuron Analysis Reveals Mitochondrial DNA Maintenance Failure Affecting Atrophying Pontine Neurons Differentially in Lewy Body Dementia Syndromes

Aging Cell, Volume 24, Issue 8, August 2025.
(a) Mitochondria contain wild‐type (black)/mutant (red) mtDNA; exceeding the mtDNA mutation threshold compromises OXPHOS, potentially driving degeneration of neurons vulnerable to age‐related neurodegenerative disease. Cellular compensations that is, mtDNA copy number upregulation and crosstalk with nuclear DNA may fail, driving neurodegeneration ...
Eloise J. Stephenson, Laura J. Bailey, Stephen Gentleman, Helen Tuppen, Istvan Bodi, Claire Troakes, Christopher M. Morris, Tony M. Carr, Sarah Guthrie, Joanna L. Elson, Ilse S. Pienaar   +10 more
wiley   +1 more source

Cholinergic Crisis Caused by Cholinesterase Inhibitors: a Retrospective Nationwide Database Study

Journal of Medical Toxicology, 2018
H. Ohbe, T. Jo, H. Matsui, K. Fushimi, H. Yasunaga   +4 more
semanticscholar   +1 more source

Risk of Antipsychotic Initiation Among Older Dementia Patients Initiating Cholinesterase Inhibitors. [PDF]

Drug Healthc Patient Saf
Chikermane SG, Li J, Aparasu RR.
europepmc   +1 more source

The New Cholinesterase Inhibitors for Alzheimer's Disease, Part 2: Illustrating Their Mechanisms of Action

, 2000
Stephen M. Stahl
openalex   +2 more sources

Resistance to inhibitors of cholinesterase 8A catalyzes release of Gαi-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Gαi-GDP complexes [PDF]

, 2005
Gregory G. Tall, Alfred G. Gilman
openalex   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, Volume 58, Issue 8, August 2025.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

The Effect of Cholinesterase Inhibitors on Neurodegeneration in Individuals with Amnestic Mild Cognitive Impairment. [PDF]

Clin Psychopharmacol Neurosci
Byeon G, Byun MS, Yi D, Ahn H, Jung G, Sohn BK, Jung JH, Chang YY, Kim K, Choi H, Kim YH, Kim YK, Kang KM, Sohn CH, Lee DY, KBASE Research Group.   +15 more
europepmc   +1 more source

RELATIONSHIP BETWEEN THE CHRONIC EXPOSURE TO PESTICIDES INHIBITORS OF CHOLINESTERASE AND PLACENTA ALTERATIONS

, 2000

openalex   +1 more source

The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Acetylcholinesterase (AChE) inhibitors are a class of drugs to treat Alzheimer's disease (AD). Our study reveals that some AChE inhibitors, for example, tacrine, disrupt the proper assembly and transport of oligomeric forms of AChE, resulting in endoplasmic reticulum (ER) stress. The ER stress ultimately leads to cell apoptosis. This tacrine‐induced ER
Xiaoyang Wang, Yingjie Xia, Maggie Suisui Guo, Jiahui Wu, Ajiaikebaier Dilidaer, Jin Gao, Tina Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim   +8 more
wiley   +1 more source

Charged Thienobenzo-1,2,3-Triazoles as Especially Potent Non-Selective Cholinesterase Inhibitors: Design, Anti-Inflammatory Activity, and Computational Study. [PDF]

Pharmaceuticals (Basel)
Jelčić A, Raspudić A, Barić D, Ratković A, Šagud I, Pongrac P, Štefok D, Bosnar M, Roca S, Lasić Z, Odak I, Škorić I.   +11 more
europepmc   +1 more source