Results 1 to 10 of about 28,022 (269)

Cholinesterase Research [PDF]

Biomolecules, 2021
Cholinesterases are fundamental players in the peripheral and central nervous systems [...]
Jan Korabecny, Ondrej Soukup
doaj   +3 more sources

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors [PDF]

Frontiers in Pharmacology
IntroductionM4 muscarinic receptor (mAChR) knockout changed the female activity biological rhythm parameters. In this study, we focus on the biological rhythms of mAChRs (total + M1 mAChRs), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE ...
Katerina Janisova, Monika Uhlirova, Sandor Forczek, Jaromir Myslivecek   +3 more
doaj   +2 more sources

Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder [PDF]

Molecules
Autism spectrum disorder is a complex neurodevelopmental disorder. The available medical treatment options for autism spectrum disorder are very limited.
Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajda   +8 more
doaj   +2 more sources

Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for ‘Alzheimer’s disease: an in silico approach

BMC Molecular and Cell Biology, 2021
The seriousness and menace of the worldwide weight of ‘Alzheimer’s disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases due to aging, environmental ...
Olalekan Olanrewaju Bakare, Adewale Oluwaseun Fadaka, Musa Oyebowale Akanbi, Kolajo Adedamola Akinyede, Ashwil Klein, Marshall Keyster   +5 more
doaj   +1 more source

Acetylcholinesterase- and Butyrylcholinesterase-Based Biosensors for the Detection of Quaternary Ammonium Biocides in Food Industry

Foods, 2023
A sensitive and robust electrochemical cholinesterase-based sensor was developed to detect the quaternary ammonium (QAs) biocides most frequently found in agri-food industry wash waters: benzalkonium chloride (BAC) and didecyldimethylammonium chloride ...
Lynn Mouawad, Georges Istamboulie, Gaëlle Catanante, Thierry Noguer   +3 more
doaj   +1 more source

Phenethyl Esters and Amide of Ferulic Acid, Hydroferulic Acid, Homovanillic Acid, and Vanillic Acid: Synthesis, Free Radicals Scavenging Activity, and Molecular Modeling as Potential Cholinesterases Inhibitors

Molbank, 2020
As ferulic acid was reported to be involved in novel potential mechanisms associated with Alzheimer’s disease (AD) therapy, five closely related phenethyl esters and amide of this natural product were synthesized and screened for their free radicals ...
Ayyoub Selka, Fanta J. Ndongou Moutombi, Marc Cormier, Mohamed Touaibia   +3 more
doaj   +1 more source

Ultrasound-Assisted Synthesis of Piperidinyl-Quinoline Acylhydrazones as New Anti-Alzheimer’s Agents: Assessment of Cholinesterase Inhibitory Profile, Molecular Docking Analysis, and Drug-like Properties

Molecules, 2023
Alzheimer’s disease (AD) is one of the progressive neurological disorders and the main cause of dementia all over the world. The multifactorial nature of Alzheimer’s disease is a reason for the lack of effective drugs as well as a basis for the ...
Rubina Munir, Sumera Zaib, Muhammad Zia-ur-Rehman, Nadia Hussain, Faryal Chaudhry, Muhammad Tayyab Younas, Fatima Tuz Zahra, Zainab Tajammul, Noman Javid, Ayed A. Dera, Hanan A. Ogaly, Imtiaz Khan   +11 more
doaj   +1 more source

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

Pharmaceuticals, 2022
Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety.
Piya Temviriyanukul, Suwapat Kittibunchakul, Piyapat Trisonthi, Thanit Kunkeaw, Woorawee Inthachat, Dalad Siriwan, Uthaiwan Suttisansanee   +6 more
doaj   +1 more source

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Biomolecules, 2019
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration.
Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny   +10 more
doaj   +1 more source

Forager bees (Apis mellifera) highly express immune and detoxification genes in tissues associated with nectar processing. [PDF]

, 2015
Pollinators, including honey bees, routinely encounter potentially harmful microorganisms and phytochemicals during foraging. However, the mechanisms by which honey bees manage these potential threats are poorly understood.
Johnson, Brian R, Mohamed, Abbas, Vannette, Rachel L   +2 more
core   +1 more source