Results 21 to 30 of about 12,810 (265)

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis

Molecules, 2020
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities.
Geum Seok Jeong, Myung-Gyun Kang, Joon Yeop Lee, Sang Ryong Lee, Daeui Park, MyoungLae Cho, Hoon Kim   +6 more
doaj   +1 more source

Exploring the enzyme inhibitory properties of Antarctic algal extracts

Türk Biyokimya Dergisi, 2023
Marine organisms obtained from Antarctica are prominent sources for many important activities. Algae are known for adapting to various adverse environmental conditions and for producing secondary metabolites with various biological activities. This study
Gözcelioğlu Bülent, Uras İbrahim Seyda, Şentürk Murat, Konuklugil Belma   +3 more
doaj   +1 more source

Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis

Fisheries and Aquatic Sciences, 2022
Anti-cholinesterase (ChE)s are commonly prescribed as the symptomatic treatment of Alzheimer’s disease. They are applied to prevent the breakdown of neurotransmitter acetylcholine (ACh) that bind to muscarinic and ...
Jun-Rui Pang, Sher-Wei How, Kah-Hui Wong, Siew-Huah Lim, Siew-Moi Phang, Yoon-Yen Yow   +5 more
doaj   +1 more source

Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS [PDF]

, 2018
Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents.
Brunetti, Luigi, Carradori, Simone, Cesa, Stefania, Chiavaroli, Annalisa, Ferrante, Claudio, Leone, Sheila, Leporini, Lidia, Locatelli, Marcello, Macchione, Nicola, Menghini, Luigi, Orlando, Giustino, Recinella, Lucia, Zengin, Gokhan   +12 more
core   +2 more sources

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Frontiers in Aging Neuroscience, 2019
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD).
Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Muhammad Junaid, Farhat Ullah, Muhammad Ovais, Muhammad Ovais, Ikram Ullah, Jawad Ahmed, Muhammad Shahid   +9 more
doaj   +1 more source

Synthesis, Structure and Evaluation of the N-(2-Acetyl-4-(styryl)phenyl)-4-benzenesulfonamide Derivatives for Anticholinesterase and Antioxidant Activities

Crystals, 2021
N-(2-Acetyl-4-bromophenyl)-4-methylbenzenesulfonamide (2) was transformed into 5-(4-methoxymethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3a) and 5-(4- trifluoromethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3b).
Malose J. Mphahlele, Samantha Gildenhuys, Sizwe J. Zamisa   +2 more
doaj   +1 more source

Nutraceutical Potential of Phenolics from ′Brava′ and ′Mansa′ Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of ′Picual′ and ′Cornicabra′

Molecules, 2018
The increasing interest in the Mediterranean diet is based on the protective effects against several diseases, including neurodegenerative disorders.
María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grande   +5 more
doaj   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

Frontiers in Chemistry, 2022
The coumarin core (i.e., 1-benzopyran-2 (2H)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic core, coumarin-containing ...
Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare   +8 more
doaj   +1 more source

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source