Results 41 to 50 of about 8,411 (245)

New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease

Pharmaceutics
Alzheimer’s disease (AD) is the most common form of dementia with no cure so far, probably due to the complexity of this multifactorial disease with diverse processes associated with its origin and progress.
Leo Bon, Angelika Banaś, Inês Dias, Inês Melo-Marques, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos   +6 more
doaj   +1 more source

Anticholinesterase Activities of Different Solvent Extracts of Brewer’s Spent Grain

Foods, 2021
Cholinesterases, involved in acetylcholine catabolism in the central and peripheral nervous system, have been strongly linked with neurodegenerative diseases. Current therapeutic approaches using synthetic drugs present several side effects. Hence, there
Rares I. Birsan, Peter Wilde, Keith W. Waldron, Dilip K. Rai   +3 more
doaj   +1 more source

THE HISTOCHEMICAL SPECIFICITY OF CHOLINESTERASES

, 1954
On the basis of a review of the biochemical and histochemical literature, all esterases are divided into the eserine-resistant esterases (aliesterases) and the eserine-sensitive esterases (cholinesterases).
RICHARD D. CHESSICK
core   +1 more source

Unusual catalytic activities and functions of cholinesterases

, 2002
Cholinesterases (acetylcholinesterase and butyrylcholinesterase) have been shown to exhibit not only esterase activity but also an amine sensitive aryl acylamidase and a metallo-carboxypeptidase activities.
Balasubramanian, A. S.
core   +2 more sources

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Frontiers in Aging Neuroscience, 2019
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD).
Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Muhammad Junaid, Farhat Ullah, Muhammad Ovais, Muhammad Ovais, Ikram Ullah, Jawad Ahmed, Muhammad Shahid   +9 more
doaj   +1 more source

Nutraceutical Potential of Phenolics from ′Brava′ and ′Mansa′ Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of ′Picual′ and ′Cornicabra′

Molecules, 2018
The increasing interest in the Mediterranean diet is based on the protective effects against several diseases, including neurodegenerative disorders.
María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grande   +5 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

In vitro inhibitory effects of selected anticholinesterase insecticides on human plasma and erythrocyte cholinesterases and their thermal reactivation [PDF]

المجلة العراقية للصيدلة, 2010
The inhibitory effect of a number of locally used organophosphorus and carbamate insecticides on human plasma and erythrocyte were examined in vitro by using the modified electrometric method for determination of cholinesterase (ChE) activity.
Omer A.H. Ahmed
doaj   +1 more source

Bis (Diamines) Cu and Zn Complexes of Flurbiprofen as Potential Cholinesterase Inhibitors: In Vitro Studies and Docking Simulations

Crystals, 2021
Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between the nerve cells and reducing the risk of dementia.
Muhammad Jamil, Nargis Sultana, Rizwan Ashraf, Maryam Bashir, Muhammad Fayyaz ur Rehman, Fariha Kanwal, Humna Ellahi, Changrui Lu, Wei Xing Zhang, Muhammad Ilyas Tariq   +9 more
doaj   +1 more source