Results 61 to 70 of about 4,982 (202)

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Self‐Reported Periodontal Symptoms and Clinical Periodontal Status in Older Adults With and Without Dementia: A Population‐Based Diagnostic Accuracy Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the diagnostic accuracy of self‐reported periodontal symptoms compared to clinical periodontal status among older adults with and without dementia. Materials and Methods This cross‐sectional study included adults ≥ 75 years of age who underwent public dental checkups in Japan.
Tomoaki Mameno, Naoko Otsuki, Satoko Takeuchi, Sho Takeda, Tomoaki Iwayama, Masahide Takedachi, Ryohei Yamamoto, Kazunori Ikebe   +7 more
wiley   +1 more source

Burden and Risk Factors of CGM‐Detected Hypoglycemia in Older Adults With Type 2 Diabetes

Journal of the American Geriatrics Society, EarlyView.
Among older adults with diabetes using insulin or sulfonylureas, the median time spent in hypoglycemia was 3.4% and ~66% of participants exceeded the target of < 1% time with CGM glucose < 70 mg/dL. ABSTRACT Background Comprehensive data on the burden of biochemical hypoglycemia in older adults with type 2 diabetes are lacking.
Michael Fang, Natalie Rula Daya, Yein Jeon, Justin B. Echouffo‐Tcheugui, B. Gwen Windham, Scott Zeger, Elizabeth Selvin   +6 more
wiley   +1 more source

Chemical characterization of sulfated polysaccharides from Gracilaria gracilis and Ulva lactuca and their radical scavenging, metal chelating, and cholinesterase inhibitory activities

International Journal of Food Properties, 2019
This study was designed to evaluate the antioxidant and cholinesterase inhibitory activities of sulfated polysaccharides from Gracilaria gracilis (PGCL) and Ulva lactuca (PULV).
Tosin A. Olasehinde, Leonard V. Mabinya, Ademola O. Olaniran, Anthony I. Okoh   +3 more
doaj   +1 more source

Development of a Video‐Based Decision Aid for Breast Cancer Screening Among Older Women

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Whether to continue breast cancer screening beyond age 74 is uncertain. Decision aids may improve understanding of health information and support informed screening decisions. The goal of this study was to develop a video‐based decision aid for breast cancer screening among older women using patient‐centered design.
Meghan E. Lindsay, Iyanuoluwa Odole, Sadde Mohamed, Claire King, Nancy L. Schoenborn, Mara A. Schonberg, Ilana B. Richman   +6 more
wiley   +1 more source

An Electronic Health Record “Nudge” to Reduce Antipsychotic Medication Prescribing for Primary Care Patients With Dementia: A Pragmatic RCT

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background We hypothesized that an electronic health record (EHR) alert grounded in behavioral science could reduce new antipsychotic medication prescriptions for older adults with dementia. Methods We conducted a pragmatic clinical trial at a large academic health system, randomizing providers to receive the alert (intervention) or not ...
Catherine A. Sarkisian, Chad Wes Villaflores, Anne M. Walling, Sitaram S. Vangala, Eric M. Cheng, Suzanne Bliven Shu, Ajaya Pillai, Grace Y. Cheng, Noah Goldstein, John Mafi   +9 more
wiley   +1 more source

On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

Molecules, 2011
The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here ...
Mihai V. Putz
doaj   +1 more source

Anticholinergic Medication Use in Veterans Affairs Long‐Term Care Residents: Clinical Patterns and Opportunities for Deprescribing

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic exposure is common in nursing homes; however, the true burden may be underestimated, particularly due to over‐the‐counter agents such as first‐generation antihistamines that are not consistently captured in prior claims‐based studies.
Cellas A. Hayes, Yongmei Li, Bocheng Jing, Laura A. Graham, Chintan Dave, Michelle C. Odden   +5 more
wiley   +1 more source

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
We investigated the influence of bronchodilating β2-agonists on the activity of human acetylcholinesterase (AChE) and usual, atypical and fluoride-resistant butyrylcholinesterase (BChE). We determined the inhibition potency of racemate and enantiomers of
Anita Bosak, Anamarija Knežević, Ivana Gazić Smilović, Goran Šinko, Zrinka Kovarik   +4 more
doaj   +1 more source

Utilization Patterns Among Heterogeneous Subgroups of Homebound Older Adults: A Latent Class Analysis

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Homebound older adults represent a high‐risk, high‐needs population characterized by significant clinical and sociodemographic heterogeneity. Little is known about how such heterogeneity shapes care needs and utilization patterns. We characterized utilization patterns among distinct subgroups of homebound older adults and examined ...
J. Lee Young, Mary L. Pomeroy, Hanna Charankevich, Katherine A. Ornstein, Bruce P. Kinosian   +4 more
wiley   +1 more source