New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease
PharmaceuticsAlzheimer’s disease (AD) is the most common form of dementia with no cure so far, probably due to the complexity of this multifactorial disease with diverse processes associated with its origin and progress.
Leo Bon +6 more
doaj +1 more source
Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]
, 2017 Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
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Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. [PDF]
, 2011 BACKGROUND: delirium is a frequent neuropsychiatric syndrome affecting medical and surgical elderly patients. Cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (AChE) and butyrylcholinesterase ...
A. Vaz-Serra +5 more
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Socio‐Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Socio‐occupational functioning in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN‐DBS) is not fully captured by standard motor and quality‐of‐life scales. Objectives To characterize patient‐reported socio‐occupational functioning after STN‐DBS and explore associated clinical and ...
Gabriele Imbalzano +7 more
wiley +1 more source
Organofosforni spojevi i esteraze: stanje sadašnjih istraživanja toksičnosti i zaštite od organofosfata [PDF]
, 2001 This brief review describes the reactions of organophosphorus compounds with cholinesterases, neuropathy target esterase, and phosphoric triester hydrolases with respect to their toxicity.
Elsa Reiner
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The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism [PDF]
, 2016 SUMMARYParasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts.
Hunt, Vicky L +3 more
core +2 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Molecules, 2019 In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and ...
Jakub Chlebek +11 more
doaj +1 more source
Fototermičke bioanalitičke metode za testiranje toksičnosti pesticida [PDF]
, 2003 This paper describes bioanalytical methods and biosensors which rely on cholinesterase (ChE) inhibition and can be used to detect and test the toxicity of organophosphate (OP) and carbamate pesticides. Particular attention is given to the combined use of
Lea Pogačnik, Mladen Franko
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Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease
Neuroprotection, EarlyView.In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong +3 more
wiley +1 more source