Results 71 to 80 of about 12,810 (265)

Error Traps in Pediatric Neuromuscular Block

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa   +5 more
wiley   +1 more source

Enantiomeri kinuklidin-3-ol derivata: Razdvajanje enantiomera i interakcija s ljudskim kolinesterazama [PDF]

open access: yes, 2005
The (R)- and (S)-enantiomers of quinuclidin-3-ol and quinuclidin-3-yl acetate as well as their quaternary N-methyl and N-benzyl derivatives were synthesized in order to study the stereoselectivity of human erythrocyte acetylcholinesterase (EC 3.1.1.7 ...
Anita Bosak   +4 more
core   +1 more source

Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins

open access: yes, 2014
14. International Symposium on Cholinergic Mechanisms (ISCM), Hangzhou, 2013/05/05-9A cholinesterase activity can be found in all kingdoms of living organism, yet cholinesterases involved in cholinergic transmission appeared only recently in the animal ...
Bourne, Yves   +4 more
core   +3 more sources

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

open access: yesPhytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo   +11 more
wiley   +1 more source

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative

open access: yesPharmaceuticals, 2020
Alzheimer’s disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective effects of
Rahim Ullah   +6 more
doaj   +1 more source

Assay optimisation and age-related baseline variation in biochemical markers in lesser black-backed gulls [PDF]

open access: yes, 2019
Free-ranging animals are often used as bioindicators of both short- and long-term changes in ecosystem health, mainly to detect the presence and effects of contaminants.
Andrade Dos Santos, Cátia Sofia   +7 more
core   +1 more source

Quantifying Population Reversibility of Sensor Performance in Multi‐Cycle Single‐Sensor Recovery Assay

open access: yesSmall, EarlyView.
Single‐walled carbon nanotubes (SWCNTs) are versatile optical nanosensors that can be imaged at the single‐sensor level to map biological processes. To translate such imaging into calibrated measurements, sensor recovery under repeated analyte exposures must be analyzed.
Geffen Rosenberg, Gili Bisker
wiley   +1 more source

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2019
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy.
Irene Pachón-Angona   +11 more
doaj   +1 more source

Comparative study of the vibrational optical activity techniques in structure elucidation : the case of galantamine [PDF]

open access: yes, 2019
The absolute configuration of the alkaloid galantamine was studied using a range of solution-state techniques; nuclear magnetic resonance (NMR), vibrational circular dichroism (VCD), and Raman optical activity (ROA). While the combined use of NMR and VCD
Bultinck, Patrick   +4 more
core   +2 more sources

HETEROZYGOTES FOR ATYPICAL CHOLINESTERASE

open access: yesBritish Journal of Anaesthesia, 1982
Three hundred and thirty-two patients undergoing electroconvulsive therapy received thiopentone and suxamethonium. In 31 the duration of the apnoea was greater than an assumed upper limit of normal of 240 s. Eight of these patients proved, on biochemical grounds, to be heterozygotes for the atypical gene. The reason why the heterozygous state is rarely
H, Owen, A R, Hunter
openaire   +2 more sources

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