Results 11 to 20 of about 4,982 (202)

Exploring the enzyme inhibitory properties of Antarctic algal extracts

Türk Biyokimya Dergisi, 2023
Marine organisms obtained from Antarctica are prominent sources for many important activities. Algae are known for adapting to various adverse environmental conditions and for producing secondary metabolites with various biological activities. This study
Gözcelioğlu Bülent, Uras İbrahim Seyda, Şentürk Murat, Konuklugil Belma   +3 more
doaj   +1 more source

Cholinesterase Research [PDF]

Biomolecules, 2021
Cholinesterases are fundamental players in the peripheral and central nervous systems [...]
Jan Korabecny, Ondrej Soukup
openaire   +3 more sources

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source

Acetylcholinesterase- and Butyrylcholinesterase-Based Biosensors for the Detection of Quaternary Ammonium Biocides in Food Industry

Foods, 2023
A sensitive and robust electrochemical cholinesterase-based sensor was developed to detect the quaternary ammonium (QAs) biocides most frequently found in agri-food industry wash waters: benzalkonium chloride (BAC) and didecyldimethylammonium chloride ...
Lynn Mouawad, Georges Istamboulie, Gaëlle Catanante, Thierry Noguer   +3 more
doaj   +1 more source

Chemical Profiling and Cholinesterase Inhibitory Activity of Five Phaedranassa Herb. (Amaryllidaceae) Species from Ecuador

Molecules, 2020
It is estimated that 50 million people in the world live with dementia, 60–70% of whom suffer from Alzheimer’s disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level.
Raúl Moreno, Luciana R. Tallini, Cristina Salazar, Edison H. Osorio, Evelin Montero, Jaume Bastida, Nora H. Oleas, Karen Acosta León   +7 more
doaj   +1 more source

Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer’s Disease Status and Risk Genotype

Frontiers in Molecular Neuroscience, 2019
Background: A fundamental question in Alzheimer’s disease (AD) is whether amyloid-β (Aβ) peptides and their deposition in the brain signify a direct pathological role or they are mere outcome of the disease pathophysiological events affecting neuronal ...
Erica Lana, Anna Gellerbring, Sabrina Jung, Agneta Nordberg, Agneta Nordberg, Christina Unger Lithner, Taher Darreh-Shori   +6 more
doaj   +1 more source

Phenethyl Esters and Amide of Ferulic Acid, Hydroferulic Acid, Homovanillic Acid, and Vanillic Acid: Synthesis, Free Radicals Scavenging Activity, and Molecular Modeling as Potential Cholinesterases Inhibitors

Molbank, 2020
As ferulic acid was reported to be involved in novel potential mechanisms associated with Alzheimer’s disease (AD) therapy, five closely related phenethyl esters and amide of this natural product were synthesized and screened for their free radicals ...
Ayyoub Selka, Fanta J. Ndongou Moutombi, Marc Cormier, Mohamed Touaibia   +3 more
doaj   +1 more source

Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis

Fisheries and Aquatic Sciences, 2022
Anti-cholinesterase (ChE)s are commonly prescribed as the symptomatic treatment of Alzheimer’s disease. They are applied to prevent the breakdown of neurotransmitter acetylcholine (ACh) that bind to muscarinic and ...
Jun-Rui Pang, Sher-Wei How, Kah-Hui Wong, Siew-Huah Lim, Siew-Moi Phang, Yoon-Yen Yow   +5 more
doaj   +1 more source

Synthesis, Structure and Evaluation of the N-(2-Acetyl-4-(styryl)phenyl)-4-benzenesulfonamide Derivatives for Anticholinesterase and Antioxidant Activities

Crystals, 2021
N-(2-Acetyl-4-bromophenyl)-4-methylbenzenesulfonamide (2) was transformed into 5-(4-methoxymethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3a) and 5-(4- trifluoromethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3b).
Malose J. Mphahlele, Samantha Gildenhuys, Sizwe J. Zamisa   +2 more
doaj   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source