Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors [PDF]
Frontiers in PharmacologyIntroductionM4 muscarinic receptor (mAChR) knockout changed the female activity biological rhythm parameters. In this study, we focus on the biological rhythms of mAChRs (total + M1 mAChRs), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE ...
Katerina Janisova +3 more
doaj +2 more sources
Organ-Specific Phytochemical Composition and Bioactivity Profiling of Chaerophyllum aksekiense: A Multiassay Antioxidant, Enzyme Inhibition, and Correlation-Based Evaluation. [PDF]
ChemistryOpenThis study reveals the organ‐specific phytochemical specialization of the endemic Chaerophyllum aksekiense for the first time. Although leaves exhibit the highest phenolic content and antioxidant capacity, flowers stand out with flavonoid accumulation, and roots demonstrate potent enzyme inhibition.
Selvi B, Bozdemir EA.
europepmc +2 more sources
Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder [PDF]
MoleculesAutism spectrum disorder is a complex neurodevelopmental disorder. The available medical treatment options for autism spectrum disorder are very limited.
Jakub Jończyk +8 more
doaj +2 more sources
Metabolites, 2022 Plants’ bioactives are well-known safe drugs for vital diseases. Flavones and Flavonoid-rich dietary supplements are known to exhibit neuroprotective potential.
Mater H. Mahnashi +10 more
doaj +1 more source
IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]
, 2011 Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David +3 more
core +1 more source
Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease
Molecules, 2017 Current research is geared towards the discovery of new compounds with strong neuroprotective potential and few or no side effects compared to synthetic drugs.
Tosin A. Olasehinde +2 more
doaj +1 more source
The Role of Cholinesterases in Post-Exercise HRV Recovery in University Volleyball Players
Applied Sciences, 2021 Some studies show interest in measuring heart rate variability (HRV) during post-exercise recovery. It is known that the parasympathetic system is relevant during this process, where one of the factors of this modulation is the interaction of ...
José Raúl Hoyos-Flores +6 more
doaj +1 more source
Molecules, 2021 Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further ...
Haya Hussain +12 more
doaj +1 more source
Forager bees (Apis mellifera) highly express immune and detoxification genes in tissues associated with nectar processing. [PDF]
, 2015 Pollinators, including honey bees, routinely encounter potentially harmful microorganisms and phytochemicals during foraging. However, the mechanisms by which honey bees manage these potential threats are poorly understood.
Johnson, Brian R +2 more
core +1 more source
Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]
, 2016 Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano +11 more
core +2 more sources