Results 11 to 20 of about 28,022 (269)

Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes

Frontiers in Pharmacology, 2018
Neuromuscular junctions (NMJs) are directly involved into such indispensable to life processes as respiration and locomotion. However, motor nerve forms only one synaptic contact at each muscle fiber.
Konstantin A. Petrov, Konstantin A. Petrov, Evgeny E. Nikolsky, Patrick Masson   +3 more
doaj   +1 more source

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease

Metabolites, 2022
Plants’ bioactives are well-known safe drugs for vital diseases. Flavones and Flavonoid-rich dietary supplements are known to exhibit neuroprotective potential.
Mater H. Mahnashi, Mohammed Abdulrahman Alshahrani, Mohammed H. Nahari, Syed Shams ul Hassan, Muhammad Saeed Jan, Muhammad Ayaz, Farhat Ullah, Osama M. Alshehri, Mohammad Ali Alshehri, Umer Rashid, Abdul Sadiq   +10 more
doaj   +1 more source

IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]

, 2011
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David, Grant, Mary, Henderson, Catherine, Large, Emma   +3 more
core   +1 more source

Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease

Molecules, 2017
Current research is geared towards the discovery of new compounds with strong neuroprotective potential and few or no side effects compared to synthetic drugs.
Tosin A. Olasehinde, Ademola O. Olaniran, Anthony I. Okoh   +2 more
doaj   +1 more source

The Role of Cholinesterases in Post-Exercise HRV Recovery in University Volleyball Players

Applied Sciences, 2021
Some studies show interest in measuring heart rate variability (HRV) during post-exercise recovery. It is known that the parasympathetic system is relevant during this process, where one of the factors of this modulation is the interaction of ...
José Raúl Hoyos-Flores, Blanca R. Rangel-Colmenero, Zeltzin N. Alonso-Ramos, Myriam Z. García-Dávila, Rosa M. Cruz-Castruita, José Naranjo-Orellana, Germán Hernández-Cruz   +6 more
doaj   +1 more source

Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]

, 2016
Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano, Costantini, Erica, DI BARI, Maria, Di Nicola, Marta, D’Angelo, Chiara, Galizia, Sabrina, Gasperini, Claudio, Orlando, Viviana, Porfilio, Italo, Reale, Marcella, Ruggieri, Serena, Tata, Ada Maria   +11 more
core   +2 more sources

Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies

Molecules, 2021
Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their promising in vitro anticholinesterase activities, they were further ...
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Mehreen Ghias, Abid Ullah, Shafiq Ur Rahman, Zul Kamal, Farman Ali Khan, Nasir Mehmood Khan, Juma Muhammad, Mazen Almehmadi, Osama Abdulaziz, Saad Alghamdi   +12 more
doaj   +1 more source

Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: Implication in peripheral inflammation [PDF]

, 2018
Multiple Sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, and both genetic and environmental factors contribute to the pathogenesis of the disease.
Costantini, Erica, D'Angelo, Chiara, D'Aurora, Marco, Di Bari, Maria, Di Nicola, Marta, Franchi, Sara, Galizia, Sabrina, Gasperini, Claudio, Gatta, Valentina, Orlando, Viviana, Reale, Marcella, Ruggieri, Serena, Stuppia, Liborio, Tata, Ada Maria   +13 more
core   +3 more sources

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis

Molecules, 2020
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities.
Geum Seok Jeong, Myung-Gyun Kang, Joon Yeop Lee, Sang Ryong Lee, Daeui Park, MyoungLae Cho, Hoon Kim   +6 more
doaj   +1 more source

Exploring the enzyme inhibitory properties of Antarctic algal extracts

Türk Biyokimya Dergisi, 2023
Marine organisms obtained from Antarctica are prominent sources for many important activities. Algae are known for adapting to various adverse environmental conditions and for producing secondary metabolites with various biological activities. This study
Gözcelioğlu Bülent, Uras İbrahim Seyda, Şentürk Murat, Konuklugil Belma   +3 more
doaj   +1 more source