Results 21 to 30 of about 118 (116)

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Bilateral Focused Ultrasound Thalamotomy for Essential Tremor: Clinical Outcomes Compared to Bilateral Deep Brain Stimulation and Probabilistic Lesion Mapping

Movement Disorders, EarlyView.
Abstract Background The efficacy and adverse events (AEs) of bilateral magnetic resonance‐guided focused ultrasound (MRgFUS) thalamotomies for essential tremor (ET) have not been compared to those of deep brain stimulation (DBS). Furthermore, it is uncertain whether second‐side thalamotomies can be positioned differently from the first without ...
Can Sarica, Kazuaki Yamamoto, Christian Iorio‐Morin, Jurgen Germann, Andrew Z. Yang, Brendan Santyr, Michael Colditz, Artur Vetkas, Anton Fomenko, Benjamin Davidson, Franziska Schmidt, Talyta Grippe, Nardin Samuel, Ajmal Zemmar, Oliver Flouty, Cletus Cheyuo, Ghazaleh Darmani, Robert Chen, Alexandre Boutet, Clemens Neudorfer, Mojgan Hodaie, Suneil K. Kalia, Renato P. Munhoz, Alfonso Fasano, Andres M. Lozano   +24 more
wiley   +1 more source

Neuronally‐Derived Extracellular Vesicles Transforming Growth Factor Beta‐1 Levels in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Differentiating progressive supranuclear palsy (PSP) from other parkinsonian disorders may be challenging. Objectives To investigate the role of transforming growth factor beta‐1 (TGFβ1) in PSP. Methods A total of 33 PSP, 39 Parkinson's disease (PD), 8 multiple system atrophy (MSA) patients, and 50 healthy controls (HC) were ...
Selena Mimmi, Elvira Immacolata Parrotta, Anna Maria Tolomeo, Domenico Maisano, Valentina Crapella, Elisabetta Pingitore, Khushboo Fatima, Anna Maria Zimbo, Mariagrazia Talarico, Costanza Maria Cristiani, Luana Scaramuzzino, Desirèe Valente, Clara Zannino, Gianni Cuda, Aldo Quattrone, Enrico Iaccino, Andrea Quattrone   +16 more
wiley   +1 more source

Cholinesterase in Junction Nevus

Journal of Investigative Dermatology, 1963
!The neural origin of all intradermal nevus cells has been proposed on the basis of their cholinesterase activity and lack of tyrosinase in contrast to the junction nevus cell (1, 2). However, tyrosinase studies of intradermal nevi after ultraviolet irradiation reveal not only an intensified dopa reaction but also a positive tyrosinase reaction in ...
Frederick F. Schaub, Yutaka Mishima
openaire   +3 more sources

Reply: “Enhancing Parkinson's Disease Research: Recommendations for Addressing Genetic and Environmental Influences in Family History Studies”

Movement Disorders Clinical Practice, EarlyView.
Federica Arienti, Edoardo Monfrini, Alessio Di Fonzo   +2 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species

ChemistryOpen, EarlyView.
The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi, Gokhan Zengin, Mehmet Veysi Cetiz, Zoltán Cziáky, József Jeko, Muammer Bahşi, Uğur Çakılcıoğlu, Halbay Turumtay, Abdurrahman Aktumsek   +8 more
wiley   +1 more source

Relationship of the revised anticholinergic drug scale with cultured cell‐based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Objective The Anticholinergic Drug Scale (ADS) is a commonly used measure of anticholinergic exposure. This study describes an expanded and revised version of the ADS (rADS) and its relationship with cultured cell‐based serum anticholinergic activity (cSAA) and cognitive measures.
Ryan M. Carnahan, Susmita Chandramouleeshwaran, Naba Ahsan, Roger Raymond, Jose N. Nobrega, Wei Wang, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista L. Lanctôt, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji   +14 more
wiley   +1 more source

Stroke Mimicking Thalamotomy in Primary Familial Brain Calcification

Movement Disorders Clinical Practice, EarlyView.
Jaakko Kungshamn, Emma Ottela, Olli Likitalo, Anna Brück, Juho Joutsa   +4 more
wiley   +1 more source

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, EarlyView.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source