Results 21 to 30 of about 28,022 (269)

Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis

Fisheries and Aquatic Sciences, 2022
Anti-cholinesterase (ChE)s are commonly prescribed as the symptomatic treatment of Alzheimer’s disease. They are applied to prevent the breakdown of neurotransmitter acetylcholine (ACh) that bind to muscarinic and ...
Jun-Rui Pang, Sher-Wei How, Kah-Hui Wong, Siew-Huah Lim, Siew-Moi Phang, Yoon-Yen Yow   +5 more
doaj   +1 more source

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Frontiers in Aging Neuroscience, 2019
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich foods significantly improve cognitive capabilities, inhibit or delay the senescence process and related neurodegenerative disorders including Alzheimer’s disease (AD).
Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Muhammad Junaid, Farhat Ullah, Muhammad Ovais, Muhammad Ovais, Ikram Ullah, Jawad Ahmed, Muhammad Shahid   +9 more
doaj   +1 more source

Synthesis, Structure and Evaluation of the N-(2-Acetyl-4-(styryl)phenyl)-4-benzenesulfonamide Derivatives for Anticholinesterase and Antioxidant Activities

Crystals, 2021
N-(2-Acetyl-4-bromophenyl)-4-methylbenzenesulfonamide (2) was transformed into 5-(4-methoxymethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3a) and 5-(4- trifluoromethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3b).
Malose J. Mphahlele, Samantha Gildenhuys, Sizwe J. Zamisa   +2 more
doaj   +1 more source

Nutraceutical Potential of Phenolics from ′Brava′ and ′Mansa′ Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of ′Picual′ and ′Cornicabra′

Molecules, 2018
The increasing interest in the Mediterranean diet is based on the protective effects against several diseases, including neurodegenerative disorders.
María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grande   +5 more
doaj   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

Frontiers in Chemistry, 2022
The coumarin core (i.e., 1-benzopyran-2 (2H)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic core, coumarin-containing ...
Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare   +8 more
doaj   +1 more source

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source

Anti-Bladder Cancer and Anti-Alzheimer Properties of Bavachin and Bavachinin as Natural Compounds with Molecular Docking and Dynamic Studies: In Vitro and in Silico Studies [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Naturally occurring substances are crucial for both the treatment and prevention of many types of cancer. Currently in therapeutic usage are over 100 naturally occurring chemicals derived from plants and animals. The symptomatic management of Alzheimer’s
Yongqing Zheng, Dapeng Zong, Shaonan Ren, Chao Wu, Liang Huang, Peng Yang   +5 more
doaj   +1 more source

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

Molecules, 2022
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical ...
Óscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles   +6 more
doaj   +1 more source

Cell transformation assays for prediction of carcinogenic potential: State of the science and future research needs [PDF]

, 2011
Copyright @ 2011 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use ...
A. D. Scott, A. Poth, A. Sakai, Asada, Ashby, Bernardi, Berwald, Berwald, Boehm, Campisi, Carmichael, Cohen, Dolma, Evan, F. L. Martin, Farmer, H. Yasaei, Haga, Huberman, Isfort, Isfort, Isfort, J. S. Harvey, K. Pant, K. Sasaki, Kelly, Kerckaert, Kirkland, Kirkland, L. M. Schechtman, Layer, LeBoeuf, LeBoeuf, M. J. Aardema, M. R. O'Donovan, Martin, Martinez-Lopez de Castro, Mauthe, McCarvill, N. Tanaka, Newbold, Newbold, P. L. Carmichael, Pang, Pant, Pant, Pfuhler, R. F. Newbold, R. R. Shen, Robinson, Russo, S. Creton, Sakai, Sakai, Schechtman, Schinzel, Shen, Sheng, Stampfer, Stinghen, Syed, Trevisan, Visvader, Walsh, Zakut, Zhao   +65 more
core   +2 more sources