Results 21 to 30 of about 12,590 (219)

In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones

Molecules, 2018
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, distinctively characterized by senile plaques, neurofibrillary tangles, and synaptic loss, finally resulting in neuronal death.
Seungeun Lee, Kumju Youn, GyuTae Lim, Jinhyuk Lee, Mira Jun   +4 more
doaj   +1 more source

Phenethyl Esters and Amide of Ferulic Acid, Hydroferulic Acid, Homovanillic Acid, and Vanillic Acid: Synthesis, Free Radicals Scavenging Activity, and Molecular Modeling as Potential Cholinesterases Inhibitors

Molbank, 2020
As ferulic acid was reported to be involved in novel potential mechanisms associated with Alzheimer’s disease (AD) therapy, five closely related phenethyl esters and amide of this natural product were synthesized and screened for their free radicals ...
Ayyoub Selka, Fanta J. Ndongou Moutombi, Marc Cormier, Mohamed Touaibia   +3 more
doaj   +1 more source

Cholinesterase inhibitory activities of neuroprotective fraction derived from red alga Gracilaria manilaensis

Fisheries and Aquatic Sciences, 2022
Anti-cholinesterase (ChE)s are commonly prescribed as the symptomatic treatment of Alzheimer’s disease. They are applied to prevent the breakdown of neurotransmitter acetylcholine (ACh) that bind to muscarinic and ...
Jun-Rui Pang, Sher-Wei How, Kah-Hui Wong, Siew-Huah Lim, Siew-Moi Phang, Yoon-Yen Yow   +5 more
doaj   +1 more source

Synthesis, Structure and Evaluation of the N-(2-Acetyl-4-(styryl)phenyl)-4-benzenesulfonamide Derivatives for Anticholinesterase and Antioxidant Activities

Crystals, 2021
N-(2-Acetyl-4-bromophenyl)-4-methylbenzenesulfonamide (2) was transformed into 5-(4-methoxymethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3a) and 5-(4- trifluoromethylstyryl)-2-(p-tolylsulfonamido)acetophenone (3b).
Malose J. Mphahlele, Samantha Gildenhuys, Sizwe J. Zamisa   +2 more
doaj   +1 more source

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases

Antioxidants, 2021
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study ...
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges   +12 more
doaj   +1 more source

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules

Frontiers in Chemistry, 2022
The coumarin core (i.e., 1-benzopyran-2 (2H)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic core, coumarin-containing ...
Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare   +8 more
doaj   +1 more source

Age-related changes of the noradrenergic and acetylcholinesterase reactive nerve fibres innervating the pigeon bursa of Fabricius. [PDF]

, 1995
Age-dependent changes in the innervation of the pigeon (Columba livia, L.) bursa of Fabricius, from hatching to 120 days of age, were studied by fluorescence-histochemical and neurochemical methods for demonstrating noradrenergic and acetylcholinesterase
A. Ricci, E. Bronzetti, E. Ciriaco, G. Germanà, J. A. Vega, MAMMOLA, CATERINA LOREDANA   +5 more
core   +1 more source

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Biomolecules, 2019
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration.
Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny   +10 more
doaj   +1 more source

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

Molecules, 2022
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical ...
Óscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles   +6 more
doaj   +1 more source

Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes

Frontiers in Pharmacology, 2018
Neuromuscular junctions (NMJs) are directly involved into such indispensable to life processes as respiration and locomotion. However, motor nerve forms only one synaptic contact at each muscle fiber.
Konstantin A. Petrov, Konstantin A. Petrov, Evgeny E. Nikolsky, Patrick Masson   +3 more
doaj   +1 more source