Results 31 to 40 of about 27,370 (335)

Comparison of the cost‐effectiveness of a computer‐assisted learning program with a tutored demonstration to teach intestinal motility to medical students [PDF]

, 1995
Computer‐based simulations of undergraduate experiments in pharmacology and physiology may offer a cost‐effective alternative to the traditional live laboratory for some students, for whom laboratory skills are less important.
Dewhurst, D. G., Leathard, H. L.
core   +2 more sources

Ultrasound-Assisted Synthesis of Piperidinyl-Quinoline Acylhydrazones as New Anti-Alzheimer’s Agents: Assessment of Cholinesterase Inhibitory Profile, Molecular Docking Analysis, and Drug-like Properties

Molecules, 2023
Alzheimer’s disease (AD) is one of the progressive neurological disorders and the main cause of dementia all over the world. The multifactorial nature of Alzheimer’s disease is a reason for the lack of effective drugs as well as a basis for the ...
Rubina Munir, Sumera Zaib, Muhammad Zia-ur-Rehman, Nadia Hussain, Faryal Chaudhry, Muhammad Tayyab Younas, Fatima Tuz Zahra, Zainab Tajammul, Noman Javid, Ayed A. Dera, Hanan A. Ogaly, Imtiaz Khan   +11 more
doaj   +1 more source

Esterases of the flounder (Platichthys flesus, Pleuronectidae, Teleostei) : development of an identification protocol using starch gel electrophoresis and characterization of loci [PDF]

, 1990
Fish esterases are among the most difficult enzymes to identify using starch gel electrophoresis because of the many loci that are simultaneously active, and especially because of duplication phenomena, satellite bands, and stain trails. In an attempt to
Berrebi, P., Borsa, P., Landaud, P., Renno, Jean-François   +3 more
core   +1 more source

Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes

Frontiers in Pharmacology, 2018
Neuromuscular junctions (NMJs) are directly involved into such indispensable to life processes as respiration and locomotion. However, motor nerve forms only one synaptic contact at each muscle fiber.
Konstantin A. Petrov, Konstantin A. Petrov, Evgeny E. Nikolsky, Patrick Masson   +3 more
doaj   +1 more source

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Biomolecules, 2019
Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration.
Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles, Jan Korabecny   +10 more
doaj   +1 more source

Nutraceutical Potential of Phenolics from ′Brava′ and ′Mansa′ Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of ′Picual′ and ′Cornicabra′

Molecules, 2018
The increasing interest in the Mediterranean diet is based on the protective effects against several diseases, including neurodegenerative disorders.
María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grande   +5 more
doaj   +1 more source

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity [PDF]

, 2017
Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications.
Alekseev, Alexander Y., Brylev, Konstantin A., Efremova, Olga A., Gulyaeva, Marina A., Ivanov, Anton A., Krasilnikova, Anna A., Kurskaya, Olga G., Mironov, Yuri V., Poveshchenko, Alexander F., Pozmogova, Tatiana N., Shestopalov, Alexander M., Shestopalov, Michael A., Shestopalova, Lidiya V., Solovieva, Anastasiya O.   +13 more
core   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

Counteracting poisoning with chemical warfare nerve agents

Arhiv za Higijenu Rada i Toksikologiju, 2020
Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
doaj   +1 more source

Exploring the enzyme inhibitory properties of Antarctic algal extracts

Türk Biyokimya Dergisi, 2023
Marine organisms obtained from Antarctica are prominent sources for many important activities. Algae are known for adapting to various adverse environmental conditions and for producing secondary metabolites with various biological activities. This study
Gözcelioğlu Bülent, Uras İbrahim Seyda, Şentürk Murat, Konuklugil Belma   +3 more
doaj   +1 more source