Results 41 to 50 of about 118 (116)

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer's disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics

Internal Medicine Journal, EarlyView.
Abstract Background New amyloid‐targeting monoclonal antibody (mAb) therapies for Alzheimer's disease (AD) are currently under review by the Therapeutic Goods Administration for use in Australia. Aims To determine the infrastructure, workforce and training needs of Australian memory and cognition clinics in order to characterise health system ...
Johannes C. Michaelian, Christopher C. Rowe, Susan E. Kurrle, Constance Dimity Pond, Michael Woodward, Sharon L. Naismith   +5 more
wiley   +1 more source

A Predictive Model of Pressure Injury in Children Undergoing Living Donor Liver Transplantation Based on Machine Learning Algorithm

Journal of Advanced Nursing, Volume 81, Issue 6, Page 3003-3012, June 2025.
ABSTRACT Aims The aim of our study was to formulate and validate a prediction model using machine learning algorithms to forecast the risk of pressure injuries (PIs) in children undergoing living donor liver transplantation (LDLT). Design A retrospective cohort study.
Xiaomei Chen, Shi Tang, Yanwen Qin, Sui Zhou, Lina Zhang, Yile Huang, Zheying Chen   +6 more
wiley   +1 more source

Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2

Journal of the American Geriatrics Society, Volume 73, Issue 3, Page 685-696, March 2025.
Abstract The rising burden of dementia calls for high‐quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI‐DAD) was designed to provide longitudinal assessments of cognition and dementia in India.
Pranali Y. Khobragade, Sarah Petrosyan, Sharmistha Dey, A. B. Dey, Jinkook Lee, on behalf of the LASI‐DAD Authorship Team, Pranali Y. Khobragade, Sarah Petrosyan, Albert Weerman, Peifeng Hu, Alden L. Gross, Joyita Banerjee, Sandy Chien, Marco Angrisani, Sara D. Adar, Leon Aksman, Niranjan Khandelwal, Anushikha Dhankhar, Harrshita Vishwakarrma, Swaroop Bhatankar, Swati Bajpai, Istikhar Ali, Masroor Anwar, Abhishek Gupta, Clarice Myers, Alka Mohan Chutani, Claire McEvoy, Danielle E. Logan, Kirsten Lynch, Ziqi Zhou, Emma Nichols, Rajeev Aravindakshan, Sankha Subhra Chakrabarti, Madhumita Priyadarshini Das, Karishma De, Minakshi Dhar, Gevesh C. Dewangan, Monica Gupta, Umar Hafiz Khan, Vishakha Jain, John P. John, Ravi Kirti, Arun Kokane, Sarabmeet Singh Lehl, Rashmi R. Mohanty, Vinay Pandit, Chhaya Rajguru, Durgesh Prasad Sahoo, Lalit Sankhe, M. Sukumar, Arunansu Talukdar, Venugopalan Gunasekaran, Joshua R. Ehrich, Elissa S. Epel, David Flood, T. V. Sekher, David E. Bloom, Kenneth M. Langa, Palanimuthu T. Sivakumar, Mathew Varghese, Mary Ganguli, Bharat Thyagarajan, Eileen M. Crimmins, Sharmistha Dey, A. B. Dey, Jinkook Lee   +65 more
wiley   +1 more source

Network Analyses to Explore Comorbidities Among Older Adults Living With Dementia

Journal of the American Geriatrics Society, Volume 73, Issue 4, Page 1168-1178, April 2025.
ABSTRACT Background Older persons living with dementia (PLWD) often have multiple other chronic health conditions (i.e., comorbidities). Network analyses can describe complex profiles of chronic health conditions through graphical displays grounded in empirical data.
Samuel Quan, Barret A. Monchka, Philip D. St. John, Malcolm B. Doupe, Maxime Turgeon, Lisa M. Lix   +5 more
wiley   +1 more source

Managing Hypercholesterolemia in Adults Older Than 75 years Without a History of Atherosclerotic Cardiovascular Disease: An Expert Clinical Consensus From the National Lipid Association and the American Geriatrics Society

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The risk of atherosclerotic cardiovascular disease increases with advancing age. Elevated LDL‐cholesterol and non‐HDL‐cholesterol levels remain predictive of incident atherosclerotic cardiovascular events among individuals older than 75 years.
Vera Bittner, Sunny A. Linnebur, Dave L. Dixon, Daniel E. Forman, Ariel R. Green, Terry A. Jacobson, Ariela R. Orkaby, Joseph J. Saseen, Salim S. Virani   +8 more
wiley   +1 more source

Assessing the Content of Goals of Care Documentation for Hospitalized Patients With Alzheimer's Disease and Related Dementias

Journal of the American Geriatrics Society, EarlyView.
Documented Patient Values and Preferences and Attendance at Goals of Care Conversations. AD/ADRD—Alzheimer's disease and related dementias. ABSTRACT Background Goals of care (GOC) conversations are an evidence‐based practice that help clarify and align patient values and preferences for medical care with treatment options.
Gina Piscitello, Jennifer Lingler, Katherine Ramos, Yael Schenker, Robert M. Arnold, Jane Schell   +5 more
wiley   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, EarlyView.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source

The evolution of muscle spindles

Experimental Physiology, EarlyView.
Abstract Muscle spindles are stretch‐sensitive mechanoreceptors found in the skeletal muscles of most four‐limbed vertebrates. They are unique amongst sensory receptors in the ability to regulate their sensitivity by contraction of the intrafusal muscle fibres on which the sensory endings lie.
Robert W. Banks, Uwe Proske
wiley   +1 more source