Results 61 to 70 of about 27,370 (335)

Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges

Molecules
The main feature of neurodegenerative diseases, including Alzheimer’s disease, is the network of complex and not fully recognized neuronal pathways and targets involved in their onset and progression.
Rebecca Orioli, Federica Belluti, Silvia Gobbi, Angela Rampa, Alessandra Bisi   +4 more
doaj   +1 more source

Organofosforni spojevi i esteraze: stanje sadašnjih istraživanja toksičnosti i zaštite od organofosfata [PDF]

, 2001
This brief review describes the reactions of organophosphorus compounds with cholinesterases, neuropathy target esterase, and phosphoric triester hydrolases with respect to their toxicity.
Elsa Reiner
core   +1 more source

The Cholinergic System and Inflammation: Common Pathways in Delirium Pathophysiology [PDF]

, 2012
OBJECTIVES: To investigate whether delirium is associated with an unbalanced inflammatory response or a dysfunctional interaction between the cholinergic and immune systems. DESIGN: Cohort observational study.
Cerejeira, J, Luís, P, Mukaetova-Ladinska, EB, Nogueira, V, Vaz-Serra, A   +4 more
core   +1 more source

Prognostic utility of advanced lung cancer inflammation index in heart failure with preserved ejection fraction

ESC Heart Failure, EarlyView.
The advanced lung cancer inflammation index (ALI) is an integrated marker of inflammation and nutritional status, calculated by body mass index × serum albumin / neutrophil‐to‐lymphocyte ratio. Low ALI levels were significantly associated with poor prognosis in elderly multimorbid HFpEF patients.
Daisuke Sakamoto, Yuki Matsuoka, Masahiro Seo, Takahisa Yamada, Daisaku Nakatani, Katsuki Okada, Akihiro Sunaga, Hirota Kida, Taiki Sato, Tetsuhisa Kitamura, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Yoshio Yasumura, Shungo Hikoso, Yohei Sotomi, Yasushi Sakata, on behalf of the OCVC‐Heart Failure Investigators   +19 more
wiley   +1 more source

Resorcinol-, catechol- and saligenin-based bronchodilating β2-agonists as inhibitors of human cholinesterase activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
We investigated the influence of bronchodilating β2-agonists on the activity of human acetylcholinesterase (AChE) and usual, atypical and fluoride-resistant butyrylcholinesterase (BChE). We determined the inhibition potency of racemate and enantiomers of
Anita Bosak, Anamarija Knežević, Ivana Gazić Smilović, Goran Šinko, Zrinka Kovarik   +4 more
doaj   +1 more source

Synthesis of N′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase

Applied Sciences, 2021
Nineteen tosylated acyl hydrazone derivatives were synthesized, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) were evaluated.
Hasan Erdinç Sellitepe, Jong Min Oh, İnci Selin Doğan, Sercan Yildirim, Ahmet Buğra Aksel, Geum Seok Jeong, Ahmed Khames, Mohamed A. Abdelgawad, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim   +11 more
doaj   +1 more source

Exploring the Multifunctional Agents of Flavonoid‐Rich Beet Leaf Extracts: Insights From Experimental and Computational Studies

Food Safety and Health, EarlyView.
ABSTRACT This study evaluated the multifunctional ability of Beta vulgaris leaves in dual therapy for Alzheimer's disease (AD) and type 2 diabetes (T2D). Flavonoid‐rich extracts of B. vulgaris leaves (FREBVL) were tested for their antidiabetic properties. The inhibition of α‐amylase and α‐glucosidase was assessed. Anti‐cholinesterase activities against
Gideon Ampoma Gyebi, Damilare Emmanuel Rotimi, Moyosoreoluwa Oduba, Ifeoma Nnonyelu, Matthew Iyobhebhe, Musiliyu Ayofe Salawu, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Adesoji Alani Olanrewaju, Abel Kolawole Oyebamiji, Mubarak Alruwaili, Naif H. Ali, Saud A. Alnaaim, Bshra A. Alsfouk, Gaber El‐Saber Batiha, Oluwafemi Adeleke Ojo   +15 more
wiley   +1 more source

Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands

Molecules, 2021
A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized.
Sergey O. Bachurin, Galina F. Makhaeva, Elena F. Shevtsova, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Pavel N. Shevtsov, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Elena A. Pushkareva, Natalia P. Boltneva, Sofya V. Lushchekina, Alexey V. Gabrelyan, Vladimir L. Zamoyski, Lyudmila G. Dubova, Elena V. Rudakova, Vladimir P. Fisenko, Elena V. Bovina, Rudy J. Richardson   +18 more
doaj   +1 more source

The Scientist, Fall 2009 [PDF]

, 2009
https://scholarworks.sjsu.edu/scientist/1005/thumbnail ...
San Jose State University, College of Science
core   +1 more source

An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos [PDF]

, 2011
The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed.
Arduini, F, Bencivenga, U, Di Tuoro, D, Lepore, M, Mita, D G, Moscone, D, Portaccio, M, Vitiello, A   +7 more
core   +1 more source