Results 71 to 80 of about 12,590 (219)

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative

Pharmaceuticals, 2020
Alzheimer’s disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective effects of
Rahim Ullah, Gowhar Ali, Nisar Ahmad, Muhammad Akram, Geeta Kumari, Muhammad Usman Amin, Muhammad Naveed Umar   +6 more
doaj   +1 more source

Updating neuropathology and neuropharmacology of monoaminergic systems [PDF]

, 2016
PreprintNon peer ...
De Deurwaerdère, Philippe, Di Giovanni, Giuseppe, Ramsay, Rona R.   +2 more
core   +2 more sources

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, EarlyView.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy.
Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili   +11 more
doaj   +1 more source

A Retrospective Chart Review of the Prevalence, Characteristics, and Discharge Destinations of Patients Hospitalized as “Social Admissions”

Journal of the American Geriatrics Society, EarlyView.
Overview of study.
Jasmine Mah, Lucy Eum, Lindsey Puddicombe, Christie Stilwell, Karen Nicholls, Hamish Frayne, Clara Long, Kristin Ko, Victoria Howatt, Margaret Man‐Ger Sun, Lynnea Lobert, Gali Latariya, Katalin Koller, Susan Freter, Maia von Maltzahn, Kenneth Rockwood, Samuel D. Searle, Melissa K. Andrew   +17 more
wiley   +1 more source

Effect of pH on Blepharisma intermedium. 5. Studies on esterases [PDF]

, 1977
Synopsis. Esterases of Blepharisma intermedium grown in buffered media of different pH values and in unbuffered media have been char­acterized. Selective inhibition studies indicate six carboxylesterases, two arylesterases and one cholinesterase in all ...
Jyothy, P.S., Shadaksharaswamy, M.
core  

Histochemical Studies on the Nervous and Humoral Regulation of Lipids and Carbohydrate Metabolism [PDF]

, 1957
The purpose of the present study is to reveal the precise mechanism of nervous and humoral regulations of lipid and carbohydrate metabolisms in the adipose tissues.
Awai, Michiyasu, Oda, Takuzo, Ohtani, Kyoichiro, Sakai, Akira   +3 more
core   +1 more source

Association of Palliative Care Initiation With Acute Healthcare Utilization Among Community‐Dwelling Adults Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Objectives To measure the association between initiating palliative care using the combined criteria of short survival expectations and increased care needs with acute healthcare utilization among community‐dwelling people living with dementia. Design A population‐level propensity‐based overlap‐weighted cohort study.
Kieran L. Quinn, Thérèse A. Stukel, Michael Pugliese, Allan S. Detsky, George Heckman, Mariam Toluwalashe Omilabu, Nathan M. Stall, Desiree Vaz, Colleen Webber, Peter Tanuseputro, Sarina Isenberg   +10 more
wiley   +1 more source

Adaptation of DETECT for Use in Home‐Based Primary Care: Clinician Perspectives

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Elder mistreatment (EM) is pervasive yet under‐identified. The Detection of Elder abuse Through Emergency Care Technicians (DETECT) tool was developed to improve EM identification and reporting among emergency medical technicians. This study explores clinician perspectives on adapting DETECT for use in home‐based primary care (HBPC).
Kristin Lees Haggerty, Randi Campetti, Olanike Ojelabi, Jason Burnett, Melvin Livingston, Carolyn Pickering, Rania Abdelkhaleq, Faith D. Atai, Thomas K. M. Cudjoe, Deborah G. Freeland, Julia Hiner, Maria Yefimova, Brad Cannell   +12 more
wiley   +1 more source