Results 71 to 80 of about 28,022 (269)
Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies
Movement Disorders, EarlyView.Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley +1 more source
The Scientist, Fall 2009 [PDF]
, 2009 https://scholarworks.sjsu.edu/scientist/1005/thumbnail ...
San Jose State University, College of Science
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Rapid Structural Analysis of Natural Products Using MicroED
Small, EarlyView.The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin +3 more
wiley +1 more source
Effect of pH on Blepharisma intermedium. 5. Studies on esterases [PDF]
, 1977 Synopsis. Esterases of Blepharisma intermedium grown in buffered media of different pH values and in unbuffered media have been characterized. Selective inhibition studies indicate six carboxylesterases, two arylesterases and one cholinesterase in all ...
Jyothy, P.S., Shadaksharaswamy, M.
core
Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]
, 2010 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert +15 more
core +6 more sources
Insect Molecular Biology, EarlyView.Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix +2 more
wiley +1 more source
Pharmaceuticals, 2020 Alzheimer’s disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective effects of
Rahim Ullah +6 more
doaj +1 more source
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Introduction Although frailty is considered a potentially modifiable risk factor for dementia, its influence on health outcomes in individuals with established dementia remains unclear. This study aims to systematize the current evidence to understand the impact of frailty on the development of adverse outcomes in older adults with dementia ...
Miguel German Borda +11 more
wiley +1 more source
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy.
Irene Pachón-Angona +11 more
doaj +1 more source
Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning [PDF]
, 2008 Background: The usefulness of a low butyrylcholinesterase (BuChE) activity on admission for predicting severity in acute organophosphorus (OP) insecticide poisoning has long been debated. Previous studies have been confounded by the inclusion of multiple
Buckley, N. A. +4 more
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