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Frontiers in Pharmacology, 2022 Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo +9 more
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Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis [PDF]
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
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ON THE SITE OF SULFATION IN THE CHONDROCYTE [PDF]
The Journal of Cell Biology, 1964 As observed autoradiographically in the cartilage of embryonic rats, radiosulfate is bound and concentrated only in vesicles of the juxtanuclear Golgi apparatus of secreting chondrocytes within 3 minutes of its presentation. From this area, vacuoles migrate peripherally and lodge in the subcortex; their sulfated contents are thence discharged via ...
Gabriel C. Godman, Nathan Lane
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Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression [PDF]
Scientific Reports, 2016 AbstractMechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by histological and ...
Xiaoning Duan +6 more
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Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway [PDF]
Scientific ReportsLow fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and
Jun Zhao, Yayi Xia, Jinwen He
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Frontiers in Cell and Developmental Biology, 2022 Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li +11 more
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The hypertrophic chondrocyte: To be or not to be.
Histology and histopathology, 2021 Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Noriaki Ono +4 more
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Cell Proliferation, 2021 Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou +9 more
semanticscholar +1 more source
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +6 more
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