Results 1 to 10 of about 174,095 (394)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Frontiers in Pharmacology, 2022
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo   +9 more
doaj   +2 more sources

TRIM3 exacerbates chondrocyte apoptosis through suppression of AKT/mTOR signaling pathway in osteoarthritis. [PDF]

J Orthop Surg Res
Ou H, Li B, Liang H, Deng H, Zhang L, Lan M, Cui X, Li S, Sun J.   +8 more
europepmc   +3 more sources

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Wei Luo, Yiming Liu, Xiguan Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
doaj   +1 more source

Three-dimensional (3D) hydrogel serves as a platform to identify potential markers of chondrocyte dedifferentiation by combining RNA sequencing

Bioactive Materials, 2021
Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers.
Yang Ling, Weiyuan Zhang, Peiyan Wang, Wanhua Xie, Wei Yang, Dong-An Wang, Changjiang Fan   +6 more
doaj   +1 more source

Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis

Pharmaceutics, 2021
Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Lee   +8 more
doaj   +1 more source

LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2021
Purpose: Extracellular Vesicles (EVs) derived from hMSCs, have the potential to alleviate cartilage damage and inflammation. We aimed to explore the effects of EVs derived from lncRNA malat‐1-overexpressing human mesenchymal stem cells (hMSCs) on ...
Chongzhi Pan, Chongzhi Pan, Chongzhi Pan, Wenzhou Huang, Wenzhou Huang, Wenzhou Huang, Qi Chen, Qi Chen, Qi Chen, Jiu Xu, Guoyu Yao, Bin Li, Bin Li, Bin Li, Bin Li, Tianlong Wu, Tianlong Wu, Tianlong Wu, Changchang Yin, Xigao Cheng, Xigao Cheng, Xigao Cheng, Xigao Cheng   +22 more
doaj   +1 more source

Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis

Stem Cells Translational Medicine, 2020
Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng, Jun‐Jiang Lian, Hai‐Jie Yang, Lei Wang, Hao‐Heng Yu, Jia‐Jia Bi, Yao‐Xin Gao, Su‐Juan Chen, Mian Wang, Zhi‐Wei Feng   +9 more
doaj   +1 more source

Doxycycline preserves chondrocyte viability and function in human and calf articular cartilage ex vivo

Physiological Reports, 2020
Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue, Brian Vuong, Hongwei Yao, Brett D. Owens   +3 more
doaj   +1 more source

CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis

Bone & Joint Research, 2022
Aims Circular RNA (circRNA) S-phase cyclin A-associated protein in the endoplasmic reticulum (ER) (circSCAPER, ID: hsa_circ_0104595) has been found to be highly expressed in osteoarthritis (OA) patients and has been associated with the severity of OA ...
Zhaxi Luobu, Lei Wang, Dahai Jiang, Tao Liao, Ciren Luobu, Luosong Qunpei   +5 more
doaj   +1 more source

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

eLife, 2021
Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett, Yuki Matsushita, Wanida Ono, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M Kronenberg, Noriaki Ono   +10 more
doaj   +1 more source