Results 1 to 10 of about 118,065 (344)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Frontiers in Pharmacology, 2022
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo   +9 more
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Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Wei Luo, Yiming Liu, Xiguan Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis

Pharmaceutics, 2021
Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Lee   +8 more
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LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2021
Purpose: Extracellular Vesicles (EVs) derived from hMSCs, have the potential to alleviate cartilage damage and inflammation. We aimed to explore the effects of EVs derived from lncRNA malat‐1-overexpressing human mesenchymal stem cells (hMSCs) on ...
Chongzhi Pan, Chongzhi Pan, Chongzhi Pan, Wenzhou Huang, Wenzhou Huang, Wenzhou Huang, Qi Chen, Qi Chen, Qi Chen, Jiu Xu, Guoyu Yao, Bin Li, Bin Li, Bin Li, Bin Li, Tianlong Wu, Tianlong Wu, Tianlong Wu, Changchang Yin, Xigao Cheng, Xigao Cheng, Xigao Cheng, Xigao Cheng   +22 more
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Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis

Stem Cells Translational Medicine, 2020
Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng, Jun‐Jiang Lian, Hai‐Jie Yang, Lei Wang, Hao‐Heng Yu, Jia‐Jia Bi, Yao‐Xin Gao, Su‐Juan Chen, Mian Wang, Zhi‐Wei Feng   +9 more
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Doxycycline preserves chondrocyte viability and function in human and calf articular cartilage ex vivo

Physiological Reports, 2020
Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue, Brian Vuong, Hongwei Yao, Brett D. Owens   +3 more
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The role of the sirtuin family in cartilage and osteoarthritis: molecular mechanisms and therapeutic targets

Arthritis Research & Therapy, 2022
Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte metabolism, an increase in the number of ...
Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li, Bin Shen   +6 more
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Three-dimensional (3D) hydrogel serves as a platform to identify potential markers of chondrocyte dedifferentiation by combining RNA sequencing

Bioactive Materials, 2021
Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers.
Yang Ling, Weiyuan Zhang, Peiyan Wang, Wanhua Xie, Wei Yang, Dong-An Wang, Changjiang Fan   +6 more
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Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Cell Reports, 2016
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng, Ailing Wu, Pikshan Li, Gang Li, Ling Qin, Hai Song, Kinglun Kingston Mak   +6 more
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Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano
Shuai Wu, Zhiguo Kai, Dong Wang, Lina Tao, Peng Zhang, Dawei Wang, Dongxing Liu, Shui Sun, Jian Zhong   +8 more
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