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Frontiers in Pharmacology, 2022 Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo +9 more
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The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
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ON THE SITE OF SULFATION IN THE CHONDROCYTE [PDF]
The Journal of Cell Biology, 1964 As observed autoradiographically in the cartilage of embryonic rats, radiosulfate is bound and concentrated only in vesicles of the juxtanuclear Golgi apparatus of secreting chondrocytes within 3 minutes of its presentation. From this area, vacuoles migrate peripherally and lodge in the subcortex; their sulfated contents are thence discharged via ...
Gabriel C. Godman, Nathan Lane
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Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
International Journal of Molecular Sciences, 2015 Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA),
Hyun Ah Kim
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Bone Research, 2018 There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures.
Patrick Aghajanian, Subburaman Mohan
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Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression [PDF]
Scientific Reports, 2016 Mechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes.
Qiang Liu +6 more
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Frontiers in Cell and Developmental Biology, 2022 Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li +11 more
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SOX9 and the many facets of its regulation in the chondrocyte lineage
Connective Tissue Research, 2017 Véronique Lefebvre, Mona Dvir-Ginzberg
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