Results 1 to 10 of about 156,620 (407)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Frontiers in Pharmacology, 2022
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo   +9 more
doaj   +2 more sources

Immunogenicity of chondrocyte sheets: a review. [PDF]

Front Immunol
The chondrocyte sheet is a sheet-like cell structure obtained by separating in vitro expanded and fused autologous chondrocytes from the bottom of the culture dish by physical means.
Li J, Sun H, Guan J, Li B, Jin C, Xie S, Liu Y.   +6 more
europepmc   +2 more sources

SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis. [PDF]

Bone Res
Chondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive.
Zu X, Chen S, Li Z, Hao L, Fu W, Zhang H, Yin Z, Wang Y, Wang J.   +8 more
europepmc   +2 more sources

Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression [PDF]

Scientific Reports, 2016
AbstractMechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by histological and ...
Xiaoning Duan, Qiang Liu, Yingfang Ao, Xin Zhang, Fengyuan Zhao, Xiaoqing Hu, Peng Yang   +6 more
openaire   +4 more sources

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Wei Luo, Yiming Liu, Xiguan Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
doaj   +1 more source

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Theranostics, 2022
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells.
Yujie Liang, Xiao Xu, Limei Xu, Zoya Iqbal, Kan Ouyang, Huawei Zhang, Chunyi Wen, Lijuan Duan, Jiang Xia   +8 more
semanticscholar   +1 more source

The hypertrophic chondrocyte: To be or not to be.

Histology and histopathology, 2021
Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Noriaki Ono, Noriaki Ono, Shawn A Hallett, Wanida Ono, Wanida Ono   +4 more
openaire   +4 more sources

Sirt6 attenuates chondrocyte senescence and osteoarthritis progression

Nature Communications, 2022
Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined.
M. Ji, Hua Jiang, Zhuang Li, Rui Geng, Jun-Zheng Hu, Yu Cheng Lin, Jun Lu   +6 more
semanticscholar   +1 more source

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

Cell Proliferation, 2021
Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou, Yingcheng Zheng, Wentian Sun, Zhenzhen Zhang, Jiaqi Liu, Wenke Yang, Wenxiu Yuan, Y. Yi, Jun Wang, Jin Liu   +9 more
semanticscholar   +1 more source

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

Frontiers in Cell and Developmental Biology, 2021
Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen, Xiaofeng Tan, Shiaw-Guang Hu, Ren-Qin Liu, Li-Hong Peng, Yongmin Li, Ping Wu   +6 more
semanticscholar   +1 more source