Results 91 to 100 of about 170,603 (392)
Rice Science, 2020 The resveratrol-enriched transgenic rice line Iksan526 (IS526), first developed by the Rural Development Administration of Korea using genetic engineering techniques, shows beneficial health effects in mitigating metabolic syndrome and obesity.
Seong-Hui Eo, Song Ja Kim
doaj +1 more source
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Advanced Functional Materials, EarlyView.Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh +3 more
wiley +1 more source
Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
doaj +1 more source
Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]
, 2012 Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo +7 more
core +2 more sources
Advanced Functional Materials, EarlyView.A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee +12 more
wiley +1 more source
The role of mitochondrial quality control mechanisms in chondrocyte senescence
Experimental GerontologyChondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte ...
Tianlei Zhao +3 more
doaj +1 more source
Cell Death and Disease, 2018 Chondrocyte loss is a prominent feature of osteoarthritis (OA). Autophagy is indispensable in maintaining the metabolic activities of cells exposed to deleterious stress.
W. Lian +8 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer +7 more
wiley +1 more source
The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation
Stem Cells International, 2016 Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors ...
Jianmei Li, S. Dong
semanticscholar +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source