Results 101 to 110 of about 118,065 (344)

PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function

Bone Research
Mechanical overloading and aging are two essential factors for osteoarthritis (OA) development. Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology, but their roles and the ...
Yan Shao, Hongbo Zhang, Hong Guan, Chunyu Wu, Weizhong Qi, Lingfeng Yang, Jianbin Yin, Haiyan Zhang, Liangliang Liu, Yuheng Lu, Yitao Zhao, Sheng Zhang, Chun Zeng, Guiqing Wang, Xiaochun Bai, Daozhang Cai   +15 more
doaj   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, EarlyView.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Development of an efficient vitrification method for chondrocyte sheets for clinical application

Regenerative Therapy, 2020
Introduction: Regenerative therapy using chondrocyte sheets is effective for osteoarthritis. The clinical application of chondrocyte sheet therapy is expected to be further advanced by the use of a feasible cryopreservation technique.
Asuka Hayashi, Miki Maehara, Ayuko Uchikura, Hitomi Matsunari, Kazuaki Matsumura, Suong-Hyu Hyon, Masato Sato, Hiroshi Nagashima   +7 more
doaj  

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions

Nature, 2013
The wide diversity of skeletal proportions in mammals is evident upon a survey of any natural history museum's collections and allows us to distinguish between species even when reduced to their calcified components.
Kimberly L. Cooper, Seungeun Oh, Yongjin Sung, R. Dasari, M. Kirschner, C. Tabin   +5 more
semanticscholar   +1 more source

4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria   +4 more
wiley   +1 more source

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence

Arthritis Research & Therapy
Background Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development.
Yucheng Lin, Lu Zhang, Mingliang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiaotao Wu, Nancy Q. Liu, Jun Lu   +8 more
doaj   +1 more source

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source

3D‐Printed Unibody Microfluidic Devices for Organ‐on‐Chip Applications

Advanced Materials Technologies, EarlyView.
A practical approach is demonstrated to 3D printing unibody microfluidic Organ‐on‐Chip (OoC) devices using commercial resins and desktop DLP printers. The demonstrated functional devices support 2D monolayers, 3D spheroids, and barrier tissues. With optimised design and post‐processing techniques, leak‐free, biocompatible microchannels and membranes ...
Louis Jun Ye Ong, Surasak Kasetsirikul, Laura A. Milton, Xiaolei Nie, Andrea W. Eiken, James Chirnside, Lucy‐May Gillian Young, Gregory P. Nordin, Yi‐Chin Toh   +8 more
wiley   +1 more source

Sulphate (35SO4) Uptake by Chondrocytes in Relation to Histological Changes in Osteo-Arthritic Human Articular Cartilage [PDF]

, 1960
D. H. Collins, T. F. McElligott
openalex   +1 more source