Results 101 to 110 of about 64,494 (318)

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence

Arthritis Research & Therapy
Background Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development.
Yucheng Lin, Lu Zhang, Mingliang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiaotao Wu, Nancy Q. Liu, Jun Lu   +8 more
doaj   +1 more source

Tailoring Piezoelectric Nanogenerators and Microdevices for Cellular Excitation: Impact of Size and Morphology

Advanced Science, EarlyView.
Piezoelectric microdevices, composed of ZnO nanosheets acting as nanogenerators and grown on silicon microparticles, are designed and fabricated to deliver precise electrical cell stimulation. This study optimizes nanosheet growth and microparticle size to enhance electrical cell activation performance while minimizing cellular internalization.
Laura Lefaix, Marc Navarro, Carme Nogués, Andreu Blanquer, Gonzalo Murillo   +4 more
wiley   +1 more source

Sulphate (35SO4) Uptake by Chondrocytes in Relation to Histological Changes in Osteo-Arthritic Human Articular Cartilage [PDF]

, 1960
D. H. Collins, T. F. McElligott
openalex   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Engineered Stem Cell Clusters for Extracellular Vesicles‐Mediated Gene Delivery to Rejuvenate Chondrocytes and Facilitate Chondrogenesis in Osteoarthritis Therapy

Advanced Science, EarlyView.
BMSCmotif+miR874/MS system is designed as a gene delivery platform utilizing engineered bone marrow mesenchymal stem cell (BMSC)‐derived extracellular vesicles (EVs) for intercellular communication to achieve sustained delivery of miRNA‐874‐3p. Rejuvenation of chondrocytes and promotion of chondrogenesis are achieved by inhibition of the NF‐κB pathway,
Yuezhou Wu, Yubo Feng, Fei Hu, Xu Zheng, Yurun Ding, Xuesong Liu, Shicheng Huo, Zhuocheng Lyu   +7 more
wiley   +1 more source

104: A sensitive technique for the measurement of the sulfation of purified proteoglycans in cultured epiphyseal growth plate chondrocytes [PDF]

, 1976
M.T. Corvol, R Rappaport
openalex   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Global existence of weak solutions to a cell migration and (de)differentiation model with double haptotaxis in the context of tissue regeneration [PDF]

arXiv
We study a model for the spread and (de)differentiation of mesenchymal stem cells and chondrocytes in a scaffold whose fibers are coated with hyaluron. The chondrocytes produce new extracellular matrix, which, together with hyaluron, serves as haptotactic cue for the stem cell migration.
arxiv  

The role of mitochondrial quality control mechanisms in chondrocyte senescence

Experimental Gerontology
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte ...
Tianlei Zhao, Dawei Niu, Yancheng Chen, Peiliang Fu   +3 more
doaj