Results 161 to 170 of about 156,620 (407)

Reaction-Diffusion-Delay Model for EPO/TNF-$α$? Interaction in Articular Cartilage Lesion Abatement [PDF]

arXiv, 2011
Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region ...
arxiv  

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]

, 2018
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J, Shen, Jie, Silverman, Richard M, Wang, Cuicui   +3 more
core   +3 more sources

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions

Nature, 2013
The wide diversity of skeletal proportions in mammals is evident upon a survey of any natural history museum's collections and allows us to distinguish between species even when reduced to their calcified components.
Kimberly L. Cooper, Seungeun Oh, Yongjin Sung, R. Dasari, M. Kirschner, C. Tabin   +5 more
semanticscholar   +1 more source

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]

, 2010
Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P., Clark, Ian M., Davidson, Rose K., Gabrielides, Christos, Kirkwood, Tom B. L., Scott, Jenny L., Swingler, Tracey E., Talyor, Robert W., Wallis, Gillian A., Young, David A.   +9 more
core   +1 more source

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence

Arthritis Research & Therapy
Background Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development.
Yucheng Lin, Lu Zhang, Mingliang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiaotao Wu, Nancy Q. Liu, Jun Lu   +8 more
doaj   +1 more source

Tailoring Piezoelectric Nanogenerators and Microdevices for Cellular Excitation: Impact of Size and Morphology

Advanced Science, EarlyView.
Piezoelectric microdevices, composed of ZnO nanosheets acting as nanogenerators and grown on silicon microparticles, are designed and fabricated to deliver precise electrical cell stimulation. This study optimizes nanosheet growth and microparticle size to enhance electrical cell activation performance while minimizing cellular internalization.
Laura Lefaix, Marc Navarro, Carme Nogués, Andreu Blanquer, Gonzalo Murillo   +4 more
wiley   +1 more source

The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]

, 2013
Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core   +3 more sources

PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function

Bone Research
Mechanical overloading and aging are two essential factors for osteoarthritis (OA) development. Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology, but their roles and the ...
Yan Shao, Hongbo Zhang, Hong Guan, Chunyu Wu, Weizhong Qi, Lingfeng Yang, Jianbin Yin, Haiyan Zhang, Liangliang Liu, Yuheng Lu, Yitao Zhao, Sheng Zhang, Chun Zeng, Guiqing Wang, Xiaochun Bai, Daozhang Cai   +15 more
doaj   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source