Results 11 to 20 of about 131,500 (355)
Expression of p16
Aging Cell, 2018 Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro‐inflammatory molecules known as the senescence‐associated secretory phenotype (SASP).
Brian O. Diekman +8 more
openalex +2 more sources
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment
Theranostics, 2022 Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells.
Yujie Liang +8 more
semanticscholar +1 more source
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
Nature Communications, 2022 Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined.
M. Ji +6 more
semanticscholar +1 more source
Cell Proliferation, 2021 Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou +9 more
semanticscholar +1 more source
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb +10 more
semanticscholar +1 more source
Chondrocyte death involvement in osteoarthritis
Cell and Tissue Research, 2022 Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis and is correlated to a number of cartilage disorders. Micromass cultures represent a convenient means for studying chondrocyte biology, and, in particular, their
S. Salucci, E. Falcieri, M. Battistelli
semanticscholar +1 more source
Ochronotic Chondropathy: A Case Report
Biomedicines, 2023 Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman +4 more
doaj +1 more source
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Journal of Cellular and Molecular Medicine, 2020 Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao +5 more
semanticscholar +1 more source
Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data
Animals, 2023 Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear.
Haoyuan Zhang +10 more
doaj +1 more source