Results 11 to 20 of about 129,913 (308)
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment
Theranostics, 2022 Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells.
Yujie Liang +8 more
semanticscholar +1 more source
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
Nature Communications, 2022 Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined.
M. Ji +6 more
semanticscholar +1 more source
Chondrocyte death involvement in osteoarthritis
Cell and Tissue Research, 2022 Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis and is correlated to a number of cartilage disorders. Micromass cultures represent a convenient means for studying chondrocyte biology, and, in particular, their
S. Salucci, E. Falcieri, M. Battistelli
semanticscholar +1 more source
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +6 more
semanticscholar +1 more source
Cell Proliferation, 2021 Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou +9 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb +10 more
semanticscholar +1 more source
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Journal of Cellular and Molecular Medicine, 2020 Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao +5 more
semanticscholar +1 more source
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
doaj +1 more source
Cell Reports, 2016 Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng +6 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte metabolism, an increase in the number of ...
Kaibo Sun +6 more
doaj +1 more source