Results 11 to 20 of about 118,065 (344)
ON THE SITE OF SULFATION IN THE CHONDROCYTE [PDF]
The Journal of Cell Biology, 1964 As observed autoradiographically in the cartilage of embryonic rats, radiosulfate is bound and concentrated only in vesicles of the juxtanuclear Golgi apparatus of secreting chondrocytes within 3 minutes of its presentation. From this area, vacuoles migrate peripherally and lodge in the subcortex; their sulfated contents are thence discharged via ...
Gabriel C. Godman, Nathan Lane
openalex +4 more sources
Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment
Theranostics, 2022 Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells.
Yujie Liang +8 more
semanticscholar +1 more source
The hypertrophic chondrocyte: To be or not to be.
Histology and histopathology, 2021 Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Noriaki Ono +4 more
openaire +4 more sources
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
Nature Communications, 2022 Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined.
M. Ji +6 more
semanticscholar +1 more source
Cell Proliferation, 2021 Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou +9 more
semanticscholar +1 more source
Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +6 more
semanticscholar +1 more source
The emerging chondrocyte channelome [PDF]
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R +3 more
openaire +6 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb +10 more
semanticscholar +1 more source
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, J. Ju
semanticscholar +1 more source