Results 191 to 200 of about 170,603 (392)

Pericellular matrix of growth plate chondrocytes: a study using postfixation with osmium-ferrocyanide. [PDF]

, 1983
Cornelia E. Farnum, Norman J. Wilsman
openalex   +1 more source

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

Advanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao, Junbiao Zhang, Yanli Liu, Lili Wang, Chunxi Huang, Wei Chi, Meixia An   +6 more
wiley   +1 more source

Stimulation of cyclic AMP in chondrocyte cultures: effects on sulfated‐proteoglycan synthesis [PDF]

, 1984
Charles J. Malemud, Robert S. Papay
openalex   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Synthesis of collagen by chondrocytes in suspension culture: Modulation by calcium, 3′:5′-cyclic AMP, and prostaglandins

, 1977
Kalindi Deshmukh, Barry D. Sawyer
openalex   +1 more source

The effects of lanthanum on the ultrastructure of hypertrophic chondrocytes and the localization of lanthanum precipitates in condylar cartilages of rats fed on normal and rachitogenic diets. [PDF]

, 1984
David C. Morris, J. Appleton
openalex   +1 more source

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

Advanced Science, EarlyView.
The synovium‐on‐a‐chip (SOC) model establishes a 3D flow‐based co‐culture of rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLSs) with M1 macrophages and endothelial cells on a microfluidic chip. This model better recapitulates the inflammatory microenvironment of RA synovium and the invasive/proliferative properties of RA FLSs in vivo ...
Wenya Diao, Yi Jiao, Tingting Deng, Jienan Gu, Bailiang Wang, Qidong Zhang, Peilong Wang, Ning Xu, Cheng Xiao   +8 more
wiley   +1 more source

Evaluation of potassium pyroantimonate/sucrose/glutaraldehyde concentration and incubation time as essential variables for localizing calcium bound to organic compounds in epiphyseal chondrocytes. [PDF]

, 1984
Herbert K. Kashiwa, N J Thiersch
openalex   +1 more source

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts

Advanced Science, EarlyView.
Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Stephanie E. Schneider, Adrienne K. Scott, Katie M. Gallagher, Emily Y. Miller, Soham Ghosh, Corey P. Neu   +5 more
wiley   +1 more source

Biosynthesis of proteoglycans by chick limb bud chondrocytes

, 1978
S. De Luca, Arnold I. Caplan, Vincent Hascall   +2 more
openalex   +1 more source