Results 261 to 270 of about 129,913 (308)

Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview. [PDF]

Cells
Povýšil C, Kaňa R, Horák M, Kaňa M.
europepmc   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis. [PDF]

Cell Mol Biol Lett
Li Y, Li H, Chen X, Li X, Su J, Yang S, Xiao W, Deng Z.   +7 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Developing Up-Scale Allogeneic Chondrocyte Therapies Using Juvenile Donor Cartilage. [PDF]

Int J Mol Sci
Hulme CH, Perry J, McCarthy HS, Lan T, Ranasinghe T, Kiely N, Freeman R, Wright J, Wright KT.   +8 more
europepmc   +1 more source

Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion

Small Science, EarlyView.
The authors propose a novel use for the conventional hypoglycemic drug, dipeptidyl peptidase IV (DPP4+) inhibitor sitagliptin. Sitagliptin prevents scar formation during wound healing through fibroblast‐to‐adipocyte conversion at least by preventing DPP4‐mediated truncation of IGF‐1.
Ju‐Lei Zhang, Jun‐Nian Zhou, Chao Tang, Yan Li, Wen‐De Yao, Ling‐Li Guo, Zhao‐Yang Chen, Ya‐Li Jia, Quan Zeng, Biao Zhang, Tao Fan, Jia‐Fei Xi, Xue‐Tao Pei, Yan Han, Wen Yue   +14 more
wiley   +1 more source

Cranial base synostosis in mice caused by upregulation of Wnt following partial inhibition of Shh. [PDF]

BMC Biol
Chen J, Ren C, Mao C, Lai Y, Lu M, Jiang Y, Chen W.   +6 more
europepmc   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

Autologous Chondrocyte Implantation Combined with High Tibial Osteotomy for Spontaneous Osteonecrosis of the Knee with a Relatively Large Cartilage Lesion in Elderly Patients. [PDF]

Cartilage
Kumagai K, Akamatsu T, Nejima S, Choe H, Ike H, Kobayashi N, Inaba Y.   +6 more
europepmc   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, EarlyView.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source