Results 21 to 30 of about 118,065 (344)
The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
K. Marberry, R. Ruhlen
openaire +3 more sources
Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
van Cc René Donkelaar, W Wouter Wilson
openaire +4 more sources
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.
New England Journal of Medicine, 1994 BACKGROUND Full-thickness defects of articular cartilage in the knee have a poor capacity for repair. They may progress to osteoarthritis and require total knee replacement.
M. Brittberg +5 more
semanticscholar +1 more source
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Journal of Cellular and Molecular Medicine, 2020 Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao +5 more
semanticscholar +1 more source
A Preliminary Study of Human Amniotic Membrane as a Potential Chondrocyte Carrier [PDF]
Malaysian Orthopaedic Journal, 2009 PURPOSE: To investigate the feasibility of using processed human amniotic membrane (HAM) to support the attachment and proliferation of chondrocytes in vitro which in turn can be utilised as a cell delivery vehicle in tissue engineering applications.
L Boo +5 more
doaj
Metaplasia of Chondrocytes into Osteoblasts
Folia Biologica, 2006 Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H Włodarski +2 more
openaire +2 more sources
In Vivo Chondrocyte Mechanics [PDF]
Biophysical Journal, 2010 Mechanical loading of joints deforms articular cartilage cells, and that these cells provide the signals for maintaining cartilage health. Excessive loading of cartilage and cells leads to cartilage degeneration and osteoarthritis.Recently, we developed a novel in vivo testing system that allows for quantification of the mechano-biology of chondrocytes
Ruth A. Seerattan +3 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2020 Excessive chondrocyte apoptosis is mostly responsible for the progression of osteoarthritis (OA). It has been shown that circular RNAs (circRNAs) are differentially expressed in OA cartilage and participate in various pathological processes during OA ...
Jinling Zhang +4 more
doaj +1 more source
Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis. [PDF]
PLoS ONE, 2015 The Integrin β1 family is the major receptors of the Extracellular matrix (ECM), and the synthesis and degradation balance of ECM is seriously disrupted during Osteoarthritis (OA).
David Garciadiego-Cázares +5 more
doaj +1 more source
Mechanisms of chondrocyte apoptosis
Osteoarthritis and Cartilage, 1999 This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Klaus Kühn +2 more
openaire +3 more sources