IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]
, 2011 Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Aldinger, Constance +6 more
core +12 more sources
Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]
, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara +4 more
core +3 more sources
Physiological Reports, 2020 Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue +3 more
doaj +1 more source
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.
New England Journal of Medicine, 1994 BACKGROUND Full-thickness defects of articular cartilage in the knee have a poor capacity for repair. They may progress to osteoarthritis and require total knee replacement.
M. Brittberg +5 more
semanticscholar +1 more source
Discerning the spatio-temporal disease patterns of surgically induced OA mouse models [PDF]
, 2019 Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM).
Becker, Jessica +8 more
core +3 more sources
Patient-oriented and performance-based outcomes after knee autologous chondrocyte implantation: a timeline for the first year of recovery [PDF]
, 2014 It is well established that autologous chondrocyte implantation (ACI) can require extended recovery postoperatively; however, little information exists to provide clinicians and patients with a timeline for anticipated function during the first year ...
English, R. A. +4 more
core +1 more source
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Journal of Cellular and Molecular Medicine, 2020 Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao +5 more
semanticscholar +1 more source
A novel culture system for modulating single cell geometry in 3D [PDF]
, 2015 Dedifferentiation of chondrocytes during in vitro expansion remains an unsolved challenge for repairing serious articular cartilage defects. In this study, a novel culture system was developed to modulate single cell geometry in 3D and investigate its ...
Glidle, Andrew +4 more
core +1 more source
Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification [PDF]
, 2017 Formation of the mandible requires progressive morphologic change, proliferation, differentiation and organization of chondrocytes preceding osteogenesis. The Wnt signaling pathway is involved in regulating bone development and maintenance.
Liao, Eric C. +2 more
core +1 more source
Arthritis Research & Therapy, 2022 Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte metabolism, an increase in the number of ...
Kaibo Sun +6 more
doaj +1 more source