Results 31 to 40 of about 118,065 (344)

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations

Cells, 2022
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro.
Noor A. Al-Maslamani, Rachel Oldershaw, Simon Tew, Jude Curran, Pieter D’Hooghe, Kazuhiro Yamamoto, Henning F. Horn   +6 more
doaj   +1 more source

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction

Bone Research, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian, Xudong Wang, X. Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guo-yan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang Su   +13 more
semanticscholar   +1 more source

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Genes & Development, 2002
To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from ...
H. Akiyama, M. Chaboissier, James F. Martin, A. Schedl, B. De Crombrugghe   +4 more
semanticscholar   +1 more source

Immunogenicity of chondrocyte sheets: a review

Frontiers in Immunology
The chondrocyte sheet is a sheet-like cell structure obtained by separating in vitro expanded and fused autologous chondrocytes from the bottom of the culture dish by physical means.
Juncen Li, Juncen Li, Juncen Li, Huilin Sun, Huilin Sun, Huilin Sun, Jiaqi Guan, Jiaqi Guan, Jiaqi Guan, Bohui Li, Bohui Li, Bohui Li, Chen Jin, Chen Jin, Chen Jin, Shanhong Xie, Shanhong Xie, Shanhong Xie, Yu Liu, Yu Liu, Yu Liu, Yu Liu   +21 more
doaj   +1 more source

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

Cells, 2021
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
Aimy Sebastian, Jillian L. McCool, Nicholas R. Hum, Deepa K. Murugesh, Stephen P. Wilson, Blaine A. Christiansen, Gabriela G. Loots   +6 more
doaj   +1 more source

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

International Journal of Molecular Sciences, 2015
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA),
H. Hwang, H. Kim
semanticscholar   +1 more source

The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering

Current Rheumatology Reports, 2019
Purpose of ReviewArticular chondrocytes are exclusively responsible for the turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are phenotypically unstable and, if they de-differentiate into hypertrophic or fibroblastic
A. Hall
semanticscholar   +1 more source

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom Minas, Tim Bryant, Takahiro Ogura
openaire   +3 more sources

Increased Expression of Sox9 during Balance of BMSCs/Chondrocyte Bricks in Platelet-Rich Plasma Promotes Construction of a Stable 3-D Chondrogenesis Microenvironment for BMSCs

Stem Cells International, 2020
Sox9 is an intrinsic transcription factor related to the determination and maintenance of chondrogenic lineage of bone marrow mesenchymal stem cells (BMSCs).
Ruikai Ba, Liang Kong, Guofeng Wu, Shiyu Liu, Yan Dong, Bei Li, Yimin Zhao   +6 more
doaj   +1 more source

Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation

Frontiers in Cell and Developmental Biology, 2022
To explain how cartilage appeared in different parts of the vertebrate body at discrete times during evolution, we hypothesize that different embryonic populations co-opted expression of a core gene regulatory network (GRN) driving chondrocyte ...
Patsy Gomez-Picos, Katie Ovens, B. Frank Eames   +2 more
doaj   +1 more source