Results 31 to 40 of about 131,500 (355)

Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is the most common and prevalent chronic joint disorders in the elderly population across the globe, resulting in severe disability and impairment of quality of life.
Ganyu Wang, Weiqiang Jing, Yuxuan Bi, Yue Li, Liang Ma, Hui Yang, Yuankai Zhang   +6 more
doaj   +1 more source

The emerging chondrocyte channelome [PDF]

Frontiers in Physiology, 2010
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R, Lewis, R, Fallman, R, Mobasheri, A   +3 more
openaire   +5 more sources

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis

Frontiers in Cell and Developmental Biology, 2021
Objective: Iron overload is common in elderly people which is associated with an increased prevalence of osteoarthritis (OA), but the exact role of iron in the development of OA has not been established.
Xingzhi Jing, Jiamin Lin, Ting Du, Zhensong Jiang, Tao Li, Guodong Wang, Xiaoyang Liu, Xingang Cui, Xingang Cui, Kai Sun   +9 more
doaj   +1 more source

TRPV4 and PIEZO Channels Mediate the Mechanosensing of Chondrocytes to the Biomechanical Microenvironment

Membranes, 2022
Articular cartilage and their chondrocytes are physiologically submitted to diverse types of mechanical cues. Chondrocytes produce and maintain the cartilage by sensing and responding to changing mechanical loads.
Min Zhang, Nan Meng, Xiaoxiao Wang, Weiyi Chen, Quanyou Zhang   +4 more
doaj   +1 more source

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Nature
Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain1.
W. Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, A. Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, P. Leucht, Ran Schwarzkopf, Edward X Guo, Jonathan Samuels, Wenhuo Hu, M. Attur, S. Waxman, Chuan-Ju Liu   +26 more
semanticscholar   +1 more source

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Genes & Development, 2002
To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from ...
H. Akiyama, M. Chaboissier, James F. Martin, A. Schedl, B. De Crombrugghe   +4 more
semanticscholar   +1 more source

Immunogenicity of chondrocyte sheets: a review

Frontiers in Immunology
The chondrocyte sheet is a sheet-like cell structure obtained by separating in vitro expanded and fused autologous chondrocytes from the bottom of the culture dish by physical means.
Juncen Li, Juncen Li, Juncen Li, Huilin Sun, Huilin Sun, Huilin Sun, Jiaqi Guan, Jiaqi Guan, Jiaqi Guan, Bohui Li, Bohui Li, Bohui Li, Chen Jin, Chen Jin, Chen Jin, Shanhong Xie, Shanhong Xie, Shanhong Xie, Yu Liu, Yu Liu, Yu Liu, Yu Liu   +21 more
doaj   +1 more source

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

eLife, 2023
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hiPSCs)
Amanda R Dicks, Grigory I Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy Steward, Wolfgang Liedtke, Colin G Nichols, Chia-Lung Wu, Farshid Guilak   +9 more
doaj   +1 more source

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction

Bone Research, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian, Xudong Wang, X. Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guo-yan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang Su   +13 more
semanticscholar   +1 more source

Iksan526 Rice Callus Extract Induces Dedifferentiation of Rabbit Articular Chondrocytes via ERK1/2 and PI-3K/Akt Pathways

Rice Science, 2020
The resveratrol-enriched transgenic rice line Iksan526 (IS526), first developed by the Rural Development Administration of Korea using genetic engineering techniques, shows beneficial health effects in mitigating metabolic syndrome and obesity.
Seong-Hui Eo, Song Ja Kim
doaj   +1 more source