Epigenetic and microRNA regulation during osteoarthritis development [PDF]
, 2015 Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology.
Chen, Di, Hui, Tianqian, Shen, Jie
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Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, Volume 13, Issue 7, 3 February 2026.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice [PDF]
, 2014 Introduction: Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, there is no direct genetic evidence
Chen, Qian +9 more
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Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background In recent years, adipose tissue (AT) transplantation has increasingly been noticed by many people in the field of tissue repair and regeneration. Accumulating evidence demonstrates that AT exerts dual functions in promoting tissue repair and conferring anti‐infective properties, with distinct biological effects attributed to its ...
Xi Duan +4 more
wiley +1 more source
Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases [PDF]
, 2013 AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment.
Banerjee, R +5 more
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A single-cell 3D dynamic volume control system for chondrocytes
BioTechniquesIn articular cartilage, zone-specific cellular morphology is a typical characteristic of cartilage tissue, which is related with chondrocyte function, inflammation and osteoarthritis (OA).
Qiang Zhang +5 more
doaj +1 more source
The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]
, 2019 The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung +7 more
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Anabolic effects of IGF-1 signaling on the skeleton [PDF]
, 2013 This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling.
Candice G. T. Tahimic +2 more
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MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression
International Journal of Molecular Sciences, 2016 Chondrocyte hypertrophy, regulated by Runt-related transcription factor 2 (RUNX2) and matrix metalloproteinase 13 (MMP13), is a crucial step in cartilage degeneration and osteoarthritis (OA) pathogenesis. We previously demonstrated that microRNA-381 (miR-
Weishen Chen +8 more
semanticscholar +1 more source
Pediatric Rheumatology Online JournalBackground Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis.
Megan M. Simonds +2 more
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