Results 91 to 100 of about 48,883 (320)

Decellularized Membrane Derived from the Cell-Produced Extracellular Matrix of 1-Day-Old Porcine Cartilage Can Be a Substitute for Periosteal Patches in Autologous Chondrocyte Implantation

Applied Sciences
(1) Autologous chondrocyte implantation (ACI) is a prominent method for treating cartilage damage, but periosteal patches can cause chondrocyte leakage.
Minh-Dung Truong, Thanh-Tam Nguyen-Thi, Thanh-Tan Nguyen-Ngoc, Bich-Tram Vo-Ngoc, Hoang-Yen Duong-Thi, Hoang-Vinh Nguyen, Duc-Quy Mai Hoang, Phuong-Vy Bui, Khanh Hong-Thien Bui, Phuong Le Thi, Dieu Linh Tran, Vo Thi Xuyen   +11 more
doaj   +1 more source

Similarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β

Journal of Orthopaedic Surgery and Research, 2022
Background Osteoarthritis (OA) is the most prevalent degenerative joint disease. In vitro experiments are an intuitive method used to investigate its early pathogenesis.
Dao-Fang Ding, Yan Xue, Jun-Peng Zhang, Zeng-Qiao Zhang, Wen-Yao Li, Yue-Long Cao, Jian-Guang Xu   +6 more
doaj   +1 more source

Cartilage on the Move: Cartilage Lineage Tracing During Tadpole Metamorphosis

, 2012
The reorganization of cranial cartilages during tadpole metamorphosis is a set of complex processes. The fates of larval cartilage-forming cells (chondrocytes) and sources of adult chondrocytes are largely unknown.
Brittain, Alison L., Buchholz, Daniel R., Hall, Brian K., Kerney, Ryan R.   +3 more
core   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Trifluoroacetate, a contaminant in purified proteins, inhibits proliferation of osteoblasts and chondrocytes [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 1999
Peptides purified by HPLC are often in the form of a trifluoroacetate (TFA) salt, because trifluoroacetic acid is used as a solvent in reversed-phase HPLC separation. However, the potential effects of this contaminant in culture systems have not been addressed previously. TFA (10−8 to 10−7 M) reduced cell numbers and thymidine incorporation into fetal
Cornish, J., Callon, K. E., Lin, C. Q X, Xiao, C. L., Mulvey, T. B., Cooper, Garth, Reid, I. R.   +6 more
openaire   +4 more sources

Auricle shaping using 3D printing and autologous diced cartilage. [PDF]

, 2019
ObjectiveTo reconstruct the auricle using a porous, hollow, three-dimensional (3D)-printed mold and autologous diced cartilage mixed with platelet-rich plasma (PRP).MethodsMaterialise Magics v20.03 was used to design a 3D, porous, hollow auricle mold ...
Chen, Jia, Chen, Yong, He, Bin, Li, Qingfeng, Liao, Junlin, Qian, Li, Wang, Aijun, Xie, Hongju, Xu, Jiaqin, Zhou, Jianda   +9 more
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease Models & Mechanisms, 2013
SUMMARY Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival.
Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs   +6 more
doaj   +1 more source

Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. [PDF]

, 1994
Epiphyseal chondrocytes cultured in a medium containing 10% serum may be maintained as three dimensional aggregates and differentiate terminally into hypertrophic cells.
Ballock, RT, Reddi, AH
core