Results 71 to 80 of about 38,240 (159)

Synoviocyte-Derived Extracellular Matrix and bFGF Speed Human Chondrocyte Proliferation While Maintaining Differentiation Potential. [PDF]

Front Bioeng Biotechnol, 2022
Truong RD, Bernier MA, Dennis JE, Kean TJ.   +3 more
europepmc   +1 more source

Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism

Stem Cell Research & Therapy
Background Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, while the mechanism by which extracellular vesicles (EVs) promote chondrocyte regeneration remains unclear. The study assessed the effect of hypoxic mesenchymal stem
Haifeng Zhang, Yanmeng Yang, Yingnan Wu, Vinitha Denslin, Yi Wei Justin Koh, Ling Liu, Wenhai Zhuo, Wing Moon Raymond Lam, Yinxian Yu, James Hoi Po Hui, Zheng Yang   +10 more
doaj   +1 more source

USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. [PDF]

Oxid Med Cell Longev, 2022
Dong X, Yang C, Luo Y, Dong W, Xu X, Wu Y, Wang J.   +6 more
europepmc   +1 more source

Dynamin inhibitor dynasore modulates longitudinal bone growth in a hormetic manner

BMC Biology
Background Longitudinal bone growth occurs via endochondral ossification, involving a complex interplay of chondrocyte proliferation, differentiation, and matrix remodeling.
Jose G. Marchan-Alvarez, Sanya Koikkara, Ruihan Zhou, Amal Nazaraliyev, Oscar P. B. Wiklander, Phillip T. Newton   +5 more
doaj   +1 more source

MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis. [PDF]

Cartilage, 2022
Zhang H, Zheng W, Li D, Zheng J.
europepmc   +1 more source

G-Protein-Coupled Estrogen Receptor-1 Positively Regulates the Growth Plate Chondrocyte Proliferation in Female Pubertal Mice. [PDF]

Front Cell Dev Biol, 2021
Chou YS, Chuang SC, Chen CH, Ho ML, Chang JK.   +4 more
europepmc   +1 more source

Extracellular vesicles from TNF-α and TGF-β1-treated ADSCs promote tissue-engineered cartilage regeneration by modulating macrophages via the miR-378a-3p/SIRPα axis

Stem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) possess immunomodulatory properties and are concurrently influenced by the local inflammatory microenvironment. Extracellular vesicles (EVs) derived from MSCs (MSCs-EVs) replicate the therapeutic effects of their ...
Yuchen Wang, Jianguo Chen, Yanlong Yang, Siyu Liu, Tian Li, Zhuoqi Chen, Yue Ma, Tianyu Huang, Haiyue Jiang, Xia Liu   +9 more
doaj   +1 more source

Long non-coding ribonucleic acid AFAP1-AS1 promotes chondrocyte proliferation via the miR-512-3p/matrix metallopeptidase 13 (MMP-13) axis. [PDF]

Bioengineered, 2022
Zhao Z, Wang Z, Pei L, Zhou X, Liu Y.
europepmc   +1 more source

Chondrocyte proliferation, viability and differentiation is declined

, 2017
Purpose: Methylphenidate (MPH) derivative drugs are used because of psychostimulants effects on attention-deficit hyperactivity disorder in children and adults. As far as we know, toxic or anti-proliferative effects of MPH against cartilage tissue were not studied in the literature.
Gumustas, F, Yilmaz, I, Sirin, DY, Gumustas, SA, Batmaz, AG, Isyar, M, Akkaya, S, Mahirogullari, M   +7 more
openaire   +2 more sources

RFLNA mitigates heat stress-impaired chondrocyte proliferation and vertebral development through cytoskeletal regulation in pigs. [PDF]

J Anim Sci Biotechnol
Yang X, Xie Y, Luo Y, Wang Y, Yang L, Zhang L, Xue P, Zha C, Fang M.   +8 more
europepmc   +1 more source