Results 61 to 70 of about 731,089 (287)

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]

Arthritis Research & Therapy, 2005
AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Tallheden, Tommi, Bengtsson, Catherine, Brantsing, Camilla, Sjögren-Jansson, Eva, Carlsson, Lars, Peterson, Lars, Brittberg, Mats, Lindahl, Anders   +7 more
openaire   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Bone growth during rapamycin therapy in young rats

BMC Pediatrics, 2009
Background Rapamycin is an effective immunosuppressant widely used to maintain the renal allograft in pediatric patients. Linear growth may be adversely affected in young children since rapamycin has potent anti-proliferative and anti-angiogenic ...
He Yu-Zhu, Sanchez Cheryl P
doaj   +1 more source

MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway

Cell Transplantation, 2020
In osteoarthritis (OA), the synthesis and decomposition of the extracellular matrix (ECM) are imbalanced. High expression levels of Wnt1-inducible signaling pathway protein 1 (WISP1) promote the synthesis of matrix metalloproteinases and induce the ...
Shujun Chen, Bo Li
doaj   +1 more source

An In Vivo Stable Isotope Labeling Method to Investigate Individual Matrix Protein Synthesis, Ribosomal Biogenesis, and Cellular Proliferation in Murine Articular Cartilage

Function, 2022
Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during aging. We describe a stable-isotope method using in vivo deuterium oxide labeling and mass spectrometry to measure protein concentration, protein half-life, cell ...
Kamil A Kobak, Albert Batushansky, Agnieszka K Borowik, Erika Prado Barboza Lopes, Frederick F Peelor, Elise L Donovan, Michael T Kinter, Benjamin F Miller, Timothy M Griffin   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Viscoelastic response of cells and the role of actin cytoskeletal remodelling. [PDF]

, 2012
PhDThe mechanical properties of living cells provide useful information on cellular structure and function. In the present study a micropipette aspiration technique was developed to investigate the viscoelastic parameters of isolated articular ...
Pravincumar, Priyanka
core   +4 more sources

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj  

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Nature Communications, 2016
mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus ...
Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai   +16 more
doaj   +1 more source

Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage [PDF]

Annals of the Rheumatic Diseases, 2003
To determine the effects of histamine on the proliferative rate of human articular chondrocytes (HAC) in vitro, and to demonstrate whether HAC in osteoarthritic (OA) cartilage express histamine and histidine decarboxylase (HDC).HAC in vitro were incubated with and without histamine in 96 well culture plates and the extent of cell proliferation was ...
L C, Tetlow, D E, Woolley
openaire   +2 more sources