Results 61 to 70 of about 38,240 (159)

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +1 more source

The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro

BMC Musculoskeletal Disorders, 2011
Background Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis and maintenance of cell viability
Baier Clemens, Grifka Joachim, Grässel Susanne, Schaumburger Jens, Balakrishnan Sanjeevi, Lechler Philipp, Straub Rainer H, Renkawitz Tobias   +7 more
doaj   +1 more source

Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity

Cellular Physiology and Biochemistry, 2013
Background/Aims: The biological effects of periodic mechanical stress on chondrocytes have been studied extensively over the past few years. However, the mechanisms underlying chondrocyte mechanosensing and signaling in response to periodic mechanical ...
Wenwei Liang, Kewei Ren, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Weimin Fan   +6 more
doaj   +1 more source

Mechanobiology of hypertrophic chondrocyte mineralization: Biomechanical regulation and therapeutic implications in skeletal disorders

Mechanobiology in Medicine
Chondrocyte proliferation, differentiation and hypertrophic mineralization are central events that guide subsequent vascular invasion and bone replacement processes.
Yuhao Liu, Guangyu Xu, Yi Shen, Shaotian Fu, An Qin   +4 more
doaj   +1 more source

Cyclic negative pressure promotes chondrocyte growth: Association of IGF-II with EGR-1

Biomolecules & Biomedicine
Knee osteoarthritis (KOA) is one of the most common degenerative joint diseases in the elderly worldwide. The primary lesion in patients with KOA is the degeneration of articular cartilage.
Xiaoyu li, Lixia Huang, Bingxue Liu, Zehua Zhang, Guoyong Zhou, Zirui Guo, Jiuhong Song, Xiang Wang   +7 more
doaj   +1 more source

Hsa_circ_0007482 Promotes Proliferation and Differentiation of Chondrocytes in Knee Osteoarthritis

CARTILAGE
Objective Knee osteoarthritis (KOA) is a complex degenerative joint disease and a major cause of joint dysfunction. This study aimed to explore the function of hsa_circ_0007482 on inflammation, proliferation, differentiation, and apoptosis in KOA. Design
Dongjie Hou, Ling Lu, Ran Tao
openaire   +2 more sources

Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation. [PDF]

Proc Natl Acad Sci U S A, 2023
Zhang J, Du L, Davis B, Gu Z, Lyu J, Zhao Z, Xu J, Morrison SJ.   +7 more
europepmc   +1 more source

Whole-Transcriptome Sequencing of Antler Tissue Reveals That circRNA2829 Regulates Chondrocyte Proliferation and Differentiation via the miR-4286-R+1/FOXO4 Axis. [PDF]

Int J Mol Sci, 2023
Yao H, Jiang R, Chen D, Li Y, Song M, Sun Z, Long G, Wu L, Hu W.   +8 more
europepmc   +1 more source

De novo serine synthesis regulates chondrocyte proliferation during bone development and repair. [PDF]

Bone Res, 2022
Stegen S, Loopmans S, Stockmans I, Moermans K, Carmeliet P, Carmeliet G.   +5 more
europepmc   +1 more source

TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis. [PDF]

Cell Commun Signal, 2022
Lin S, Li H, Wu B, Shang J, Jiang N, Peng R, Xing B, Xu X, Lu H.   +8 more
europepmc   +1 more source