Results 41 to 50 of about 731,089 (287)

Introducing monitoring and automation in cartilage tissue engineering, toward controlled clinical translation [PDF]

, 2011
The clinical application of tissue engineered products requires to be tightly connected with the possibility to control the process, assess graft quality and define suitable release criteria for implantation.
Santoro, Rosaria
core   +1 more source

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source

Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis

Membranes, 2022
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang   +4 more
doaj   +1 more source

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

International Journal of Molecular Medicine, 2018
SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation. SOX9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte ...
Safdar, Hussain, Mengyao, Sun, Yuanxu, Guo, Nosheen, Mushtaq, Yitong, Zhao, Ying, Yuan, Nazim, Hussain, Ezra, Osoro, Abubakar, Suleiman, Muhammad, Sadiq, Fujun, Zhang, Yan, Han, Jian, Sun, Shemin, Lu   +13 more
openaire   +3 more sources

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source

Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]

, 2012
Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Sylvie Miot, Giuseppe M. Peretti, I. Martin, Peretti, Giuseppe M., Barbero, Andrea, S. Miot, A. Barbero, Miot, Sylvie, C. Scotti, Osmokrovic, Andrea, Celeste Scotti, A. Osmokrovic, Wolf, Francine, F. Wolf, Andrea Barbero, Scotti, Celeste, Francine Wolf, Martin, Ivan, Ivan Martin, G. Peretti, Andrea Osmokrovic   +20 more
core   +1 more source

Does intradiscal steroid injection accelerate the histological degeneration of the human disc?

Osteoporosis and Sarcopenia
Objectives: Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is
Jin Hwan Kim, Sunhee Chang, Byung Ho Kim, Gyu Heon Lee, Sung Tan Cho   +4 more
doaj   +1 more source

Involvement of α5β1 Integrin in Matrix Interactions and Proliferation of Chondrocytes [PDF]

Journal of Bone and Mineral Research, 1997
Abstract Integrins are cell surface receptors involved in cellular processes including adhesion, migration, and matrix assembly. In the present study, we analyzed the possible involvement of α5β1 integrin in the regulation of chondrocyte adhesion, spreading, and proliferation.
M, Enomoto-Iwamoto, M, Iwamoto, K, Nakashima, Y, Mukudai, D, Boettiger, M, Pacifici, K, Kurisu, F, Suzuki   +7 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source