Results 41 to 50 of about 57,848 (292)

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

International Journal of Molecular Medicine, 2018
SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation. SOX9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte ...
Safdar, Hussain, Mengyao, Sun, Yuanxu, Guo, Nosheen, Mushtaq, Yitong, Zhao, Ying, Yuan, Nazim, Hussain, Ezra, Osoro, Abubakar, Suleiman, Muhammad, Sadiq, Fujun, Zhang, Yan, Han, Jian, Sun, Shemin, Lu   +13 more
openaire   +3 more sources

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Cell Reports, 2016
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng, Ailing Wu, Pikshan Li, Gang Li, Ling Qin, Hai Song, Kinglun Kingston Mak   +6 more
doaj   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes

Journal of Animal Science and Biotechnology, 2012
Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B, Belanger Janelle M, Oberbauer Anita M   +2 more
doaj   +1 more source

Bushen Tongluowan promotes chondrocyte proliferation through multi-gene regulation

Pharmacological Research - Modern Chinese Medicine, 2022
Traditional Chinese orthopedics has a long history and excellent clinical effects in the treatment of osteoarthritis (OA). Bushen Tongluowan (BSTLW) is a representative prescription based on ''kidney governing bones'' theory in Traditional Chinese ...
Lu Bocheng, Zhou Zhenwei, Zhang Pengcheng, Huang Jianjun, Li Qingmiao, Zhao Xiaolin, Qu Tingli, Zheng Qian   +7 more
doaj   +1 more source

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]

, 2018
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J, Shen, Jie, Silverman, Richard M, Wang, Cuicui   +3 more
core   +3 more sources

TAZ is required for chondrogenesis and skeletal development

Cell Discovery, 2021
Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li, Shuting Yang, Ling Qin, Shuying Yang   +3 more
doaj   +1 more source

Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes [PDF]

Regenerative Biomaterials, 2022
AbstractAutologous chondrocytes (C cells) are effective sources of cell therapy for engineering cartilage tissue to repair chondral defects, such as degenerative arthritis. The expansion of cells with C cell characteristics has become a major challenge due to inadequate donor sites and poor proliferation of mature C cells.
Chien-Liang Ho, Lynn L H Huang, Shyh-Jou Shieh   +2 more
openaire   +2 more sources

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]

, 2020
Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A, Hum, Nicholas R, Loots, Gabriela G, McCool, Jillian L, Mendez, Melanie E, Murugesh, Deepa K, Rios-Arce, Naiomy D, Sebastian, Aimy   +7 more
core   +2 more sources

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]

Arthritis Research & Therapy, 2005
AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Tallheden, Tommi, Bengtsson, Catherine, Brantsing, Camilla, Sjögren-Jansson, Eva, Carlsson, Lars, Peterson, Lars, Brittberg, Mats, Lindahl, Anders   +7 more
openaire   +2 more sources