Results 41 to 50 of about 38,240 (159)

Bone growth during rapamycin therapy in young rats

BMC Pediatrics, 2009
Background Rapamycin is an effective immunosuppressant widely used to maintain the renal allograft in pediatric patients. Linear growth may be adversely affected in young children since rapamycin has potent anti-proliferative and anti-angiogenic ...
He Yu-Zhu, Sanchez Cheryl P
doaj   +1 more source

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]

Arthritis Research & Therapy, 2005
AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Tallheden, Tommi, Bengtsson, Catherine, Brantsing, Camilla, Sjögren-Jansson, Eva, Carlsson, Lars, Peterson, Lars, Brittberg, Mats, Lindahl, Anders   +7 more
openaire   +2 more sources

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj  

An In Vivo Stable Isotope Labeling Method to Investigate Individual Matrix Protein Synthesis, Ribosomal Biogenesis, and Cellular Proliferation in Murine Articular Cartilage

Function, 2022
Targeting chondrocyte dynamics is a strategy for slowing osteoarthritis progression during aging. We describe a stable-isotope method using in vivo deuterium oxide labeling and mass spectrometry to measure protein concentration, protein half-life, cell ...
Kamil A Kobak, Albert Batushansky, Agnieszka K Borowik, Erika Prado Barboza Lopes, Frederick F Peelor, Elise L Donovan, Michael T Kinter, Benjamin F Miller, Timothy M Griffin   +8 more
doaj   +1 more source

In vitro exposure of human chondrocytes to pulsed electromagnetic fields

European Journal of Histochemistry, 2009
The effect of pulsed electromagnetic fields (PEMFs) on the proliferation and survival of matrix-induced autologous chondrocyte implantation (MACI®)-derived cells was studied to ascertain the healing potential of PEMFs.
V Nicolin, C Ponti, G Baldini, D Gibellini, R Bortul, M Zweyer, B Martinelli, P Narducci   +7 more
doaj   +1 more source

MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway

Cell Transplantation, 2020
In osteoarthritis (OA), the synthesis and decomposition of the extracellular matrix (ECM) are imbalanced. High expression levels of Wnt1-inducible signaling pathway protein 1 (WISP1) promote the synthesis of matrix metalloproteinases and induce the ...
Shujun Chen, Bo Li
doaj   +1 more source

Recombinant human midkine stimulates proliferation of articular chondrocytes [PDF]

Cell Proliferation, 2010
AbstractObjectives:  Midkine, a heparin‐binding growth factor, promotes population growth, survival and migration of several cell types, but its effect on articular chondrocytes remains unknown. The aim of this study was to investigate its role on proliferation of articular chondrocytes in vitro and in vivo.Materials and methods:  Bromodeoxyuridine ...
Z H, Zhang, H X, Li, Y P, Qi, L J, Du, S Y, Zhu, M Y, Wu, H L, Lu, Y, Yu, W, Han   +8 more
openaire   +2 more sources

Growth plate closure and therapeutic interventions [PDF]

Clinical and Experimental Pediatrics
Height gains result from longitudinal bone growth, which is largely dependent on chondrocyte differentiation and proliferation within the growth plates of long bones. The growth plate, that is, the epiphyseal plate, is divided into resting, proliferative,
Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim   +2 more
doaj   +1 more source

Osteopontin‐induced lncRNA HOTAIR expression is involved in osteoarthritis by regulating cell proliferation

BMC Geriatrics, 2021
Background Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in
Quanzhi Liang, Ailijiang Asila, Yingjie Deng, Jun Liao, Zhenfeng Liu, Rui Fang   +5 more
doaj   +1 more source

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation [PDF]

Proceedings of the National Academy of Sciences, 2008
Small noncoding RNAs, microRNAs (miRNAs), bind to messenger RNAs through base pairing to suppress gene expression. Despite accumulating evidence that miRNAs play critical roles in various biological processes across diverse organisms, their roles in mammalian skeletal development have not been demonstrated. Here, we show that Dicer,
Kobayashi, Tatsuya, Lu, Jun, Cobb, Bradley S., Rodda, Stephen J., McMahon, Andrew P., Schipani, Ernestina, Merkenschlager, Matthias, Kronenberg, Henry M.   +7 more
openaire   +4 more sources