Results 21 to 30 of about 38,240 (159)
Journal of Animal Science and Biotechnology, 2012 Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B +2 more
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TAZ is required for chondrogenesis and skeletal development
Cell Discovery, 2021 Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li +3 more
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Syndecan-3 Is a Selective Regulator of Chondrocyte Proliferation [PDF]
Journal of Biological Chemistry, 2002 Chondrocyte proliferation is important for skeletal development and growth, but the mechanisms regulating it are not completely clear. Previously, we showed that syndecan-3, a cell surface heparan sulfate proteoglycan, is expressed by proliferating chondrocytes in vivo and that proliferation of cultured chondrocytes in vitro is sensitive to ...
Thorsten, Kirsch +4 more
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Bushen Tongluowan promotes chondrocyte proliferation through multi-gene regulation
Pharmacological Research - Modern Chinese Medicine, 2022 Traditional Chinese orthopedics has a long history and excellent clinical effects in the treatment of osteoarthritis (OA). Bushen Tongluowan (BSTLW) is a representative prescription based on ''kidney governing bones'' theory in Traditional Chinese ...
Lu Bocheng +7 more
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The viability and proliferation of human chondrocytes following cryopreservation [PDF]
The Journal of Bone and Joint Surgery. British volume, 2008 Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z +4 more
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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes [PDF]
The Journal of Cell Biology, 2003 Chondrocyte proliferation and differentiation requires their attachment to the collagen type II–rich matrix of developing bone. This interaction is mediated by integrins and their cytoplasmic effectors, such as the integrin-linked kinase (ILK). To elucidate the molecular mechanisms whereby integrins control these processes, we have specifically ...
Terpstra, Leonieke +6 more
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Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation [PDF]
Molecular and Cellular Biology, 2014 Mammalian DREAM is a conserved protein complex that functions in cellular quiescence. DREAM contains an E2F, a retinoblastoma (RB)-family protein, and the MuvB core (LIN9, LIN37, LIN52, LIN54, and RBBP4). In mammals, MuvB can alternatively bind to BMYB to form a complex that promotes mitotic gene expression.
Forristal, Chantal +15 more
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Integrin‐linked kinase regulates chondrocyte shape and proliferation [PDF]
The EMBO Reports, 2003 The interaction of chondrocytes with the extracellular-matrix environment is mediated mainly by integrins. Ligated integrins are recruited to focal adhesions (FAs) together with scaffolding proteins and kinases, such as integrin-linked kinase (Ilk). Ilk binds the cytoplasmic domain of beta1-, beta2- and beta3-integrins and recruits adaptors and kinases,
Grashoff, C. +4 more
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Cellular Physiology and Biochemistry, 2015 Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang +9 more
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Membranes, 2022 In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang +4 more
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