WNT signalling in joint repair and homeostasis [PDF]
, 2011 PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
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Brazilian Journal of Medical and Biological Research, 2011 The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren +9 more
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The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]
, 2011 Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Matthias F. Pietschmann +13 more
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Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia [PDF]
, 2000 Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C +9 more
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Smad4 regulates growth plate matrix production and chondrocyte polarity
Biology Open, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker +4 more
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Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]
, 2007 The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Candrian, Christian +7 more
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The viability and proliferation of human chondrocytes following cryopreservation [PDF]
The Journal of Bone and Joint Surgery. British volume, 2008 Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z +4 more
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Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]
, 2011 Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P. +19 more
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Cell Reports, 2016 Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng +6 more
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The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 [PDF]
, 2007 Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti ...
Farquharson, C +7 more
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