Results 21 to 30 of about 38,162 (257)

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes [PDF]

The Journal of Cell Biology, 2003
Chondrocyte proliferation and differentiation requires their attachment to the collagen type II–rich matrix of developing bone. This interaction is mediated by integrins and their cytoplasmic effectors, such as the integrin-linked kinase (ILK). To elucidate the molecular mechanisms whereby integrins control these processes, we have specifically ...
Terpstra, Leonieke, Prud'homme, Josée, Arabian, Alice, Takeda, Shu, Karsenty, Gérard, Dedhar, Shoukat, St-Arnaud, René   +6 more
openaire   +2 more sources

The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration. [PDF]

Cartilage, 2021
Objective Autologous chondrocyte implantation is a necessary procedure for the repair of articular cartilage defects; however, isolated chondrocyte implantation requires a 2-step procedure (for harvesting and implantation) and is limited by cytotoxicity due to enzymatic digestion.
Tsuyuguchi Y, Nakasa T, Ishikawa M, Miyaki S, Matsushita R, Kanemitsu M, Adachi N.   +6 more
europepmc   +4 more sources

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Cell Reports, 2016
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng, Ailing Wu, Pikshan Li, Gang Li, Ling Qin, Hai Song, Kinglun Kingston Mak   +6 more
doaj   +1 more source

Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation [PDF]

Molecular and Cellular Biology, 2014
Mammalian DREAM is a conserved protein complex that functions in cellular quiescence. DREAM contains an E2F, a retinoblastoma (RB)-family protein, and the MuvB core (LIN9, LIN37, LIN52, LIN54, and RBBP4). In mammals, MuvB can alternatively bind to BMYB to form a complex that promotes mitotic gene expression.
Forristal, Chantal, Henley, Shauna A., MacDonald, James I., Bush, Jason R., Ort, Carley, Passos, Daniel T., Talluri, Srikanth, Ishak, Charles A., Thwaites, Michael J., Norley, Chris J., Litovchick, Larisa, DeCaprio, James A., DiMattia, Gabriel, Holdsworth, David W., Beier, Frank, Dick, Frederick A.   +15 more
openaire   +4 more sources

Bushen Tongluowan promotes chondrocyte proliferation through multi-gene regulation

Pharmacological Research - Modern Chinese Medicine, 2022
Traditional Chinese orthopedics has a long history and excellent clinical effects in the treatment of osteoarthritis (OA). Bushen Tongluowan (BSTLW) is a representative prescription based on ''kidney governing bones'' theory in Traditional Chinese ...
Lu Bocheng, Zhou Zhenwei, Zhang Pengcheng, Huang Jianjun, Li Qingmiao, Zhao Xiaolin, Qu Tingli, Zheng Qian   +7 more
doaj   +1 more source

Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes

Journal of Animal Science and Biotechnology, 2012
Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B, Belanger Janelle M, Oberbauer Anita M   +2 more
doaj   +1 more source

Integrin‐linked kinase regulates chondrocyte shape and proliferation [PDF]

EMBO reports, 2003
The interaction of chondrocytes with the extracellular‐matrix environment is mediated mainly by integrins. Ligated integrins are recruited to focal adhesions (FAs) together with scaffolding proteins and kinases, such as integrin‐linked kinase (Ilk). Ilk binds the cytoplasmic domain of β1‐, β2‐ and β3‐integrins and recruits adaptors and kinases, and is ...
Grashoff, C., Aszodi, A., Sakai, T., Hunziker, E., Fässler, R.   +4 more
openaire   +4 more sources

TAZ is required for chondrogenesis and skeletal development

Cell Discovery, 2021
Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li, Shuting Yang, Ling Qin, Shuying Yang   +3 more
doaj   +1 more source

Involvement of α5β1 Integrin in Matrix Interactions and Proliferation of Chondrocytes [PDF]

Journal of Bone and Mineral Research, 1997
Abstract Integrins are cell surface receptors involved in cellular processes including adhesion, migration, and matrix assembly. In the present study, we analyzed the possible involvement of α5β1 integrin in the regulation of chondrocyte adhesion, spreading, and proliferation.
M, Enomoto-Iwamoto, M, Iwamoto, K, Nakashima, Y, Mukudai, D, Boettiger, M, Pacifici, K, Kurisu, F, Suzuki   +7 more
openaire   +2 more sources

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source