Molecular Mechanisms of Chondrocyte Proliferation and Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen +15 more
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Smad4 regulates growth plate matrix production and chondrocyte polarity [PDF]
Biology Open, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker +4 more
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P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background The disruption of chondrocyte proliferation and differentiation is a critical event during the process of joint injury in osteoarthritis (OA).
Yuanli Li +3 more
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Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway [PDF]
Scientific ReportsLow fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and
Jun Zhao, Yayi Xia, Jinwen He
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Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones. [PDF]
PLoS ONE, 2019 Atonal homolog 8 (Atoh8) is a transcription factor of the basic helix-loop-helix (bHLH) protein family, which is expressed in the cartilaginous elements of endochondral bones. To analyze its function during chondrogenesis we deleted Atoh8 in mice using a
Nadine Schroeder +4 more
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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes [PDF]
The Journal of Cell Biology, 2003 Chondrocyte proliferation and differentiation requires their attachment to the collagen type II–rich matrix of developing bone. This interaction is mediated by integrins and their cytoplasmic effectors, such as the integrin-linked kinase (ILK). To elucidate the molecular mechanisms whereby integrins control these processes, we have specifically ...
Terpstra, Leonieke +6 more
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G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation [PDF]
Bone & Joint ResearchAims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou +6 more
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mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
Nature Communications, 2016 mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus ...
Bo Yan +16 more
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Frontiers in Bioengineering and Biotechnology, 2021 Purpose: Extracellular Vesicles (EVs) derived from hMSCs, have the potential to alleviate cartilage damage and inflammation. We aimed to explore the effects of EVs derived from lncRNA malat‐1-overexpressing human mesenchymal stem cells (hMSCs) on ...
Chongzhi Pan +22 more
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Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
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