Results 11 to 20 of about 38,162 (257)
Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes [PDF]
Stem Cells International, 2017 Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for ...
Jie Shi +6 more
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Arthritis Research & Therapy, 2023 Background Osteoarthritis (OA) is a degenerative disease related to cholesterol metabolism disorders. However, current therapies for OA are insufficient and no convincing disease-modifying OA drugs exist. Therefore, we aimed to elucidate the mechanism by
WeiBing Wang +9 more
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Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis (OA) is a joint disease characterized via destruction of cartilage. Chondrocyte damage is associated with cartilage destruction during OA.
Jipeng Lu, Zhongxiong Wu, Ying Xiong
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Journal of Orthopaedic Surgery and Research, 2022 Background This study aimed to analyze the in vitro effect of micro-strain stress on the proliferation and functional marker expression in chondrocytes isolated from human osteoarthritis cartilage samples.
Bin Zhao +3 more
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Journal of Nanobiotechnology, 2021 Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration.
Shenglong Li +4 more
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miR-29b inhibits TGF-β1-induced cell proliferation in articular chondrocytes
Biochemistry and Biophysics Reports, 2022 Transforming growth factor β1 (TGF-β1) is a known regulator of chondrocyte proliferation and promotes cartilage repair in osteoarthritis (OA). microRNA-29b-3p (miR-29b-3p) is downregulated by TGF-β1 and overexpressed in OA cartilage. However, the ability
Masahiro Horita +4 more
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Brazilian Journal of Medical and Biological Research, 2011 The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren +9 more
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Syndecan-3 Is a Selective Regulator of Chondrocyte Proliferation [PDF]
Journal of Biological Chemistry, 2002 Chondrocyte proliferation is important for skeletal development and growth, but the mechanisms regulating it are not completely clear. Previously, we showed that syndecan-3, a cell surface heparan sulfate proteoglycan, is expressed by proliferating chondrocytes in vivo and that proliferation of cultured chondrocytes in vitro is sensitive to ...
Thorsten, Kirsch +4 more
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Smad4 regulates growth plate matrix production and chondrocyte polarity
Biology Open, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker +4 more
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The viability and proliferation of human chondrocytes following cryopreservation [PDF]
The Journal of Bone and Joint Surgery. British volume, 2008 Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z +4 more
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