Results 31 to 40 of about 38,240 (159)

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

International Journal of Molecular Medicine, 2018
SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation. SOX9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte ...
Safdar, Hussain, Mengyao, Sun, Yuanxu, Guo, Nosheen, Mushtaq, Yitong, Zhao, Ying, Yuan, Nazim, Hussain, Ezra, Osoro, Abubakar, Suleiman, Muhammad, Sadiq, Fujun, Zhang, Yan, Han, Jian, Sun, Shemin, Lu   +13 more
openaire   +3 more sources

Does intradiscal steroid injection accelerate the histological degeneration of the human disc?

Osteoporosis and Sarcopenia
Objectives: Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is
Jin Hwan Kim, Sunhee Chang, Byung Ho Kim, Gyu Heon Lee, Sung Tan Cho   +4 more
doaj   +1 more source

Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure

Gels, 2021
Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and ...
Guanhuier Wang, Yang An, Xinling Zhang, Pengbing Ding, Hongsen Bi, Zhenmin Zhao   +5 more
doaj   +1 more source

Involvement of α5β1 Integrin in Matrix Interactions and Proliferation of Chondrocytes [PDF]

Journal of Bone and Mineral Research, 1997
Abstract Integrins are cell surface receptors involved in cellular processes including adhesion, migration, and matrix assembly. In the present study, we analyzed the possible involvement of α5β1 integrin in the regulation of chondrocyte adhesion, spreading, and proliferation.
M, Enomoto-Iwamoto, M, Iwamoto, K, Nakashima, Y, Mukudai, D, Boettiger, M, Pacifici, K, Kurisu, F, Suzuki   +7 more
openaire   +2 more sources

Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation [PDF]

Molecular and Cellular Biology, 2010
Calpains are calcium-dependent intracellular cysteine proteases, which include ubiquitously expressed mu- and m-calpains. Both calpains are heterodimers consisting of a large catalytic subunit and a small regulatory subunit. The calpain small subunit encoded by the gene Capn4 directly binds to the intracellular C-terminal tail of the receptor for the ...
Aki, Kashiwagi, Ernestina, Schipani, Mikaela J, Fein, Peter A, Greer, Masako, Shimada   +4 more
openaire   +2 more sources

Development of fibrocartilage layers in the anterior cruciate ligament insertion in rabbits

BMC Musculoskeletal Disorders, 2019
Background A detailed evaluation focusing on the fibrocartilage layers in the anterior cruciate ligament (ACL) insertion is necessary to consider regeneration of the insertion.
Hirotaka Mutsuzaki, Hiromi Nakajima, Maika Someji, Masataka Sakane   +3 more
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Evaluation of the effect of mesenchymal stromal cells from different sources on human chondrocyte proliferation

Вестник трансплантологии и искусственных органов
Objective: to study the effect of a conditioned medium of mesenchymal stromal cells (MSCs) from different sources on human chondrocyte proliferation.Materials and methods.
A. D. Belova, Yu. B. Basok, A. M. Grigoriev, L. A. Kirsanova, E. G. Kuznetsova, I. V. Vakhrushev, A. V. Kovalev, K. N. Yarygin, V. I. Sevastianov   +8 more
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mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

Nature Communications, 2016
mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus ...
Bo Yan, Zhongmin Zhang, Dadi Jin, Chen Cai, Chunhong Jia, Wen Liu, Ting Wang, Shengfa Li, Haiyan Zhang, Bin Huang, Pinglin Lai, Hua Wang, Anling Liu, Chun Zeng, Daozhang Cai, Yu Jiang, Xiaochun Bai   +16 more
doaj   +1 more source