Results 31 to 40 of about 38,162 (257)

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

International Journal of Molecular Medicine, 2018
SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation. SOX9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte ...
Safdar, Hussain, Mengyao, Sun, Yuanxu, Guo, Nosheen, Mushtaq, Yitong, Zhao, Ying, Yuan, Nazim, Hussain, Ezra, Osoro, Abubakar, Suleiman, Muhammad, Sadiq, Fujun, Zhang, Yan, Han, Jian, Sun, Shemin, Lu   +13 more
openaire   +3 more sources

Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis

Membranes, 2022
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang   +4 more
doaj   +1 more source

Targeted Deletion of Capn4 in Cells of the Chondrocyte Lineage Impairs Chondrocyte Proliferation and Differentiation [PDF]

Molecular and Cellular Biology, 2010
Calpains are calcium-dependent intracellular cysteine proteases, which include ubiquitously expressed mu- and m-calpains. Both calpains are heterodimers consisting of a large catalytic subunit and a small regulatory subunit. The calpain small subunit encoded by the gene Capn4 directly binds to the intracellular C-terminal tail of the receptor for the ...
Aki, Kashiwagi, Ernestina, Schipani, Mikaela J, Fein, Peter A, Greer, Masako, Shimada   +4 more
openaire   +2 more sources

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients [PDF]

Arthritis Research & Therapy, 2005
AbstractAutologous chondrocyte transplantation (ACT) has been shown, in long-term follow-up studies, to be a promising treatment for the repair of isolated cartilage lesions. The method is based on an implantation of in vitro expanded chondrocytes originating from a small cartilage biopsy harvested from a non-weight-bearing area within the joint.
Tallheden, Tommi, Bengtsson, Catherine, Brantsing, Camilla, Sjögren-Jansson, Eva, Carlsson, Lars, Peterson, Lars, Brittberg, Mats, Lindahl, Anders   +7 more
openaire   +2 more sources

Does intradiscal steroid injection accelerate the histological degeneration of the human disc?

Osteoporosis and Sarcopenia
Objectives: Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is
Jin Hwan Kim, Sunhee Chang, Byung Ho Kim, Gyu Heon Lee, Sung Tan Cho   +4 more
doaj   +1 more source

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation [PDF]

Proceedings of the National Academy of Sciences, 2008
Small noncoding RNAs, microRNAs (miRNAs), bind to messenger RNAs through base pairing to suppress gene expression. Despite accumulating evidence that miRNAs play critical roles in various biological processes across diverse organisms, their roles in mammalian skeletal development have not been demonstrated. Here, we show that Dicer,
Kobayashi, Tatsuya, Lu, Jun, Cobb, Bradley S., Rodda, Stephen J., McMahon, Andrew P., Schipani, Ernestina, Merkenschlager, Matthias, Kronenberg, Henry M.   +7 more
openaire   +4 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure

Gels, 2021
Three-dimensional cell-laden tissue engineering has become an extensive research direction. This study aimed to evaluate whether chondrocyte spheroids (chondro-spheroids) prepared using the hanging-drop method could develop better cell proliferation and ...
Guanhuier Wang, Yang An, Xinling Zhang, Pengbing Ding, Hongsen Bi, Zhenmin Zhao   +5 more
doaj   +1 more source