Results 51 to 60 of about 57,848 (292)

Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression [PDF]

Osteoarthritis and Cartilage, 2007
To investigate the effects of glucosamine (GlcN) on chondrocyte proliferation, matrix production, and gene expression for providing insights into the biochemical basis of its reported beneficial effects in osteoarthritis (OA).Dose-dependent effect of GlcN on cell morphology, proliferation, cartilage matrix production and gene expression was examined by
Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J., Elisseeff, J.H.   +5 more
openaire   +2 more sources

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source

Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis

Membranes, 2022
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and extracellular vesicles (EVs) may play a major role in the efficacy of this treatment.
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang   +4 more
doaj   +1 more source

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b. [PDF]

Cell Cycle, 2018
Wang R, Xu B, Xu H.
europepmc   +2 more sources

Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering [PDF]

, 2013
Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering.
AM Martins, AR Fajardo, BC Heng, C Albrecht, C Chung, C Detzel, C Kirkpatrick, C Vinatier, Clemens A. Van Blitterswijk, D Puppi, E Miranda, EJ Menzel, FH Chen, FT Moutos, GV Martins, H Fan, J Almodo?var, JF Mano, JF Mano, JF Piai, JK Francis Suh, JM Sobral, JM Varghese, Joana M. Silva, João F. Mano, JRE Fraser, JS Mao, JS Pieper, JS Temenoff, K Anselme, K Köhler, K Von Der Mark, L Wu, L-P Yan, L-P Yan, M Kubo, Marcel Karperien, MV Voinova, Mário A. Barbosa, Nicole Georgi, NM Alves, O Franke, P Sher, Praveen Sher, R Jin, R Servaty, RG LeBaron, RR Costa, RR Costa, Rui Costa, Rui L. Reis, S Chatterjee, S Ghosh, S-H Lee, SC Neves, T Boudou, T Crouzier, W Sui, W-C Chen, WH Dietmar, Y Gong, Y Liu, Z Tang   +62 more
core   +7 more sources

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

The viability and proliferation of human chondrocytes following cryopreservation [PDF]

The Journal of Bone and Joint Surgery. British volume, 2008
Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z, Murray, D, Hulley, P, Triffitt, J, Price, A   +4 more
openaire   +6 more sources

Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]

, 2006
Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Brochhausen, Christoph, Neuland, Pia, Kirkpatrick, Charles James, Nüsing, Rolf M., Klaus, Günter   +4 more
core   +1 more source

Effect of Oxygen Tension on Tissue-Engineered Human Nasal Septal Chondrocytes

Allergy & Rhinology, 2014
Tissue-engineered nasal septal cartilage may provide a source of autologous tissue for repair of craniofacial defects. Although advances have been made in manipulating the chondrocyte culture environment for production of neocartilage, consensus on the ...
Chih-Wen Twu M.D., Marsha S. Reuther M.D., Kristen K. Briggs Ph.D., Robert L. Sah M.D. Sc.D., Koichi Masuda M.D., Deborah Watson M.D. F.A.C.S.   +5 more
doaj   +1 more source