Results 51 to 60 of about 38,240 (159)

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +1 more source

Decellularized Membrane Derived from the Cell-Produced Extracellular Matrix of 1-Day-Old Porcine Cartilage Can Be a Substitute for Periosteal Patches in Autologous Chondrocyte Implantation

Applied Sciences
(1) Autologous chondrocyte implantation (ACI) is a prominent method for treating cartilage damage, but periosteal patches can cause chondrocyte leakage.
Minh-Dung Truong, Thanh-Tam Nguyen-Thi, Thanh-Tan Nguyen-Ngoc, Bich-Tram Vo-Ngoc, Hoang-Yen Duong-Thi, Hoang-Vinh Nguyen, Duc-Quy Mai Hoang, Phuong-Vy Bui, Khanh Hong-Thien Bui, Phuong Le Thi, Dieu Linh Tran, Vo Thi Xuyen   +11 more
doaj   +1 more source

Predominant Promotion by Tacrolimus of Chondrogenic Differentiation to Proliferating Chondrocytes

Journal of Pharmacological Sciences, 2009
Tacrolimus (FK506) has been used as a therapeutic drug beneficial for the treatment of rheumatoid arthritis in humans. In this study, we investigated the effects of FK506 on cellular differentiation in cultured chondrogenic cells. Culture with FK506 led to a significant and concentration-dependent increase in Alcian blue staining for matrix ...
Nakamura, Yukari, Takarada, Takeshi, Kodama, Ayumi, Hinoi, Eiichi, Yoneda, Yukio   +4 more
openaire   +4 more sources

Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes

International Journal of Nanomedicine, 2016
Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Chondral and ...
Bhardwaj G, Webster TJ
doaj  

KIF22 regulates mitosis and proliferation of chondrocyte cells

iScience
Point mutations in KIF22 have been linked to spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2). Skeletal features of SEMDJL2 include short stature and joint laxity. Mechanisms underlying these limb abnormalities are unknown. Here in this manuscript, we have investigated the function of KIF22 in chondrocytes.
Hiroka Kawaue, Takuma Matsubara, Kenichi Nagano, Aoi Ikedo, Thira Rojasawasthien, Anna Yoshimura, Chihiro Nakatomi, Yuuki Imai, Yoshimitsu Kakuta, William N. Addison, Shoichiro Kokabu   +10 more
openaire   +3 more sources

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease Models & Mechanisms, 2013
SUMMARY Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival.
Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs   +6 more
doaj   +1 more source

Isorhamnetin inhibits mechanical stress-induced chondrocyte apoptosis through activation of the ROS/SRC/FOXO1 signaling pathway

Scientific Reports
Intervertebral disc degeneration (IDD), a chronic degenerative disease, is characterized by pain without a satisfactory therapeutic strategy. Excessive mechanical pressure contributes to the pathological development of IDD by inducing chondrocyte ...
Jinliang Lai, Guoqiang Yin, Fanmao Zhu, Jishang Huang, Xinghua Hu, Lei Liao, Rong Wu, Jiayu Tao, Shuyue Wang, Yang Xiao, Yiming Gu, Shan Li, Jie Zhou, Yadong Yang   +13 more
doaj   +1 more source

Pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway

Journal of Occupational Medicine and Toxicology, 2011
Background Pilose antler polypeptides (PAP) have been reported to promote chondrocyte proliferation. However, the underlying mechanism remains unclear. The present study was to investigate the effects of PAP on the proliferation of chondrocytes and its ...
Lin Jian-Hua, Deng Ling-Xiao, Wu Zhao-Yang, Chen Lei, Zhang Li   +4 more
doaj   +1 more source

miR-1737 targets TAK1 to mediate the BMP-Smad signaling pathway to regulate the molecular mechanism of chicken tibial chondrodysplasia

Poultry Science
Tibial dyschondroplasia (TD) is a prevalent skeletal disorder in the modern broiler poultry industry. MicroRNAs (miRNAs) regulate various biological processes. Our previous studies suggest miR-1737 plays a role in cartilage development, but its mechanism
Hengyong Xu, Ranran Du, Xiaojie Xie, Yuxiang Lu, Zhi Hu, Xuyang Ji, Longge Guo, Xinqi Wang, Yiping Liu, Zengrong Zhang, Yan Wang   +10 more
doaj   +1 more source

miR‐373 regulates inflammatory cytokine‐mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor

FEBS Open Bio, 2018
Inflammatory cytokines commonly initiate extreme changes in the synovium and cartilage microenvironment of osteoarthritis (OA) patients, which subsequently cause cellular dysfunction, especially in chondrocytes. It has been reported that induction of the
Wei Zhang, Biao Zhong, Chi Zhang, Congfeng Luo, Yulin Zhan   +4 more
doaj   +1 more source