Results 141 to 150 of about 1,182,907 (370)

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Nature Communications, 2016
Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression.
J. Lui, P. Garrison, Quang Nguyen, Michal Ad, C. Keembiyehetty, WeiPing Chen, Y. Jee, E. Landman, O. Nilsson, K. Barnes, J. Baron   +10 more
semanticscholar   +1 more source

Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues

Advanced Science, EarlyView.
This study presents a novel 4D bioprinting platform for engineering biomimetic musculoskeletal grafts. By tuning the mechanical properties of support baths, we enhance tissue fusion, collagen alignment, and cell differentiation. Using this strategy, we successfully fabricate scaled‐up, anisotropic tissues such as meniscus, articular cartilage, and ...
Francesca D. Spagnuolo, Gabriela S. Kronemberger, Daniel J. Kelly   +2 more
wiley   +1 more source

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +1 more source

The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro

BMC Musculoskeletal Disorders, 2011
Background Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis and maintenance of cell viability
Baier Clemens, Grifka Joachim, Grässel Susanne, Schaumburger Jens, Balakrishnan Sanjeevi, Lechler Philipp, Straub Rainer H, Renkawitz Tobias   +7 more
doaj   +1 more source

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth

Development, 2016
Fibroblast growth factor (FGF) signaling is important for skeletal development; however, cell-specific functions, redundancy and feedback mechanisms regulating bone growth are poorly understood.
Kannan Karuppaiah, Kai Yu, Joohyun Lim, Jianquan Chen, Craig Smith, Fanxin Long, D. Ornitz   +6 more
semanticscholar   +1 more source

Bone growth following demineralized bone matrix implantation requires angiogenesis [PDF]

, 2016
Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear.
Lam, Stephanie
core  

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, Control of Proliferation, and Hypertrophy in Chondrocytes [PDF]

, 1998
Motomi Enomoto‐Iwamoto, Masahiro Iwamoto, Yoshiki Mukudai, Yasuhiko Kawakami, Tsutomu Nohno, Yoshinobu Higuchi, Seiji Takemoto, Hideyo Ohuchi, Sumihare Noji, Kojiro Kurisu   +9 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy

European Cells & Materials, 2018
High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI).
JG Sykes, JH Kuiper, JB Richardson, S Roberts, KT Wright, NJ Kuiper   +5 more
doaj   +1 more source