Results 251 to 260 of about 101,193 (316)

Dysregulation of the glycolysis-mitochondrial metabolism axis in osteoarthritis: mechanisms and therapeutic implications. [PDF]

J Orthop Translat
Zhang R, Chen SZ, Guo SC, Tao SC.
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategies. [PDF]

Drug Des Devel Ther
Liang Y, Wang K, Yang C, Huang J, Huang Z, Chen Y.   +5 more
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Multiple strategies, one mission: mesenchymal stromal cell-based mechanisms of action in osteoarthritis. [PDF]

Front Cell Dev Biol
Junuzović M, Troillet A, Burk J.
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Chondrocytes <i>versus</i> chondroprogenitors for auricular cartilage repair: a critical comparative review. [PDF]

Front Cell Dev Biol
Jiang A, Luan W, He L.
europepmc   +1 more source

YKL-40 alleviates the TNF-α-Induced chondrocyte injury in osteoarthritis in vitro. [PDF]

Sci Rep
Li Z, Sun X, Xie Y, Hong Z, Dou Z, Yan S, Zhang Y, Qin H, Liu D, Feng T, Wang G.   +10 more
europepmc   +1 more source

Abnormal Stress Reduced miR-330 Supplementation Alleviates Osteoarthritis Progression by Suppressing Osteochondral Catabolism. [PDF]

Aging Cell
Zou L, Yang K, Wang C, Yu Y, Zhang X, Lu C, Zhao J, Qin A, He D.   +8 more
europepmc   +1 more source