Results 271 to 280 of about 101,193 (316)
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Science Translational Medicine, 2018
An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al ., this issue).
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An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al ., this issue).
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A biography of the chondrocyte
Annals of the Rheumatic Diseases, 2008Significant gaps persist in our understanding of chondrocyte biology. We do not know when, how, or even whether these cells are replenished throughout the normal, human life span. We are taught that as much as 90% of the cartilage is "metabolically inert" interterritorial matrix, but we do not know how this substance is regularly replaced (as it is ...
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Tissue Engineering with Chondrocytes
Facial Plastic Surgery, 2002Tissue engineering of cartilage, using chondrocytes based on the use of synthetic biodegradable polymer cell delivery vehicles (scaffolds), is an alternate treatment modality for replacing missing cartilage. Cartilage tissue engineering has an important role to play in the generation of graft material for head and neck reconstruction. It is an approach
R James, Koch, Goutham Krishna, Gorti
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Phenotype of chondrocytes in osteoarthritis
Biorheology, 2008Articular cartilage is composed by a unique cell population, the chondrocytes, embedded in an abundant extra-cellular matrix (ECM). Growth, differentiation and homeostasis of the cartilage are regulated by an intricate interplay between the chondrocytes and ECM, which allows the matrix to send signals to the chondrocytes and the chondrocytes to sense ...
IANNONE, Florenzo, LAPADULA, Giovanni
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Prevention of Chondrocyte Apoptosis
The Journal of Bone and Joint Surgery-American Volume, 2001The occurrence of chondrocyte apoptosis may be critical in determining the extent of a lesion and subsequent repair after mechanical injury to articular cartilage. Agents that prevent apoptosis and increase chondrocyte survival may prove beneficial in the treatment of these lesions.
D D, D'Lima +4 more
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In situ chondrocyte viscoelasticity
Journal of Biomechanics, 2012It has been proposed, based on theoretical considerations, that the strain rate-dependent viscoelastic response of cartilage reduces local tissue and cell deformations during cyclic compressions. However, experimental studies have not addressed the in situ viscoelastic response of chondrocytes under static and dynamic loading conditions. In particular,
Sang-Kuy, Han +3 more
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Mitochondrial granules in chondrocytes
Calcified Tissue Research, 1969Rat and mice epiphyseal growth plates were studied with the electron microscope. A gradient of mitochondrial electron-dense granules was found. Chondrocytes in the proliferative zone had few granules, while those of the succeeding zones showed a gradual increase in number and density until the zone of provisional calcification was reached.
J H, Martin, J L, Matthews
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Chondrocyte Isolation and Expansion
2022Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small clusters, over a period of a few days in monolayer culture.
Paul, Harrison +4 more
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The breakdown of collagen by chondrocytes
The Journal of Pathology, 1980The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone ...
R W, Jubb, H B, Fell
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Journal of Ultrastructure Research, 1967
Electron microscopic investigation of embryonic mouse radii reveals that chondrocytes in epiphyseal cartilage can form single cilia. The cilia can be distinguished from ordinary microvilli by their greater length and the organization of their bases, which are formed by a centriole accompanied by a second one in the near neighborhood.
J P, Scherft, W T, Daems
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Electron microscopic investigation of embryonic mouse radii reveals that chondrocytes in epiphyseal cartilage can form single cilia. The cilia can be distinguished from ordinary microvilli by their greater length and the organization of their bases, which are formed by a centriole accompanied by a second one in the near neighborhood.
J P, Scherft, W T, Daems
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