Results 61 to 70 of about 213,570 (404)

Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]

, 2013
The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van, Georgi, N., Karperien, H.B.J., Leijten, J.C.H., Wu, L.   +4 more
core   +3 more sources

Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond

International Journal of Molecular Sciences, 2019
Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal ...
Shawn A. Hallett, W. Ono, N. Ono
semanticscholar   +1 more source

Cadmium Toxicity on Chondrocytes and the Palliative Effects of 1α, 25-Dihydroxy Vitamin D3 in White Leghorns Chicken's Embryo

Frontiers in Veterinary Science, 2021
Cadmium (Cd) can causes osteoporosis and joint swelling. However, the mechanism of Cd toxicity in chondrocytes and how to alleviate Cd poisoning to chondrocytes are still unclear.
Jianhong Gu, Jianhong Gu, Jianhong Gu, Saihui Li, Saihui Li, Guoshuai Wang, Guoshuai Wang, Xueqing Zhang, Xueqing Zhang, Yan Yuan, Yan Yuan, Xuezhong Liu, Xuezhong Liu, Xuezhong Liu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Xishuai Tong, Xishuai Tong, Xishuai Tong, Xishuai Tong, Zongping Liu, Zongping Liu, Zongping Liu, Zongping Liu   +24 more
doaj   +1 more source

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +2 more sources

An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination [PDF]

, 2021
Regulating the activity of matrix metalloproteinases (MMPs) is a potential strategy for osteoarthritis (OA) therapy, although delivering this effect in a spatially and temporally localised fashion remains a challenge. Here, we report an injectable and self-healing hydrogel enabling factor-free MMP regulation and biomechanical competence in situ.
arxiv   +1 more source

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

Aging, 2019
Osteoarthritis (OA) is a common degenerative joint disorder, which involves articular cartilage degeneration as well as joint inflammatory reactions.
Chen-Ge Cai, Shaoxiong Min, B. Yan, Wen Liu, X. Yang, Liuxun Li, Ting Wang, Anmin Jin   +7 more
semanticscholar   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj  

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom Minas, Tim Bryant, Takahiro Ogura
openaire   +3 more sources