Results 61 to 70 of about 216,956 (381)

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

Aging, 2019
Osteoarthritis (OA) is a common degenerative joint disorder, which involves articular cartilage degeneration as well as joint inflammatory reactions.
Chen-Ge Cai, Shaoxiong Min, B. Yan, Wen Liu, X. Yang, Liuxun Li, Ting Wang, Anmin Jin   +7 more
semanticscholar   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Cartilage on the Move: Cartilage Lineage Tracing During Tadpole Metamorphosis

, 2012
The reorganization of cranial cartilages during tadpole metamorphosis is a set of complex processes. The fates of larval cartilage-forming cells (chondrocytes) and sources of adult chondrocytes are largely unknown.
Brittain, Alison L., Buchholz, Daniel R., Hall, Brian K., Kerney, Ryan R.   +3 more
core   +1 more source

Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]

, 2007
The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Andrea Barbero, Cherubino P., Christian Candrian, Christina-Priska Sie, Eloit M, Gobbi A., Ivan Martin, Michael Heberer, Roberto Tommasini, Rupert Hagg, Silvia-Elena Francioli, Watt F.M, Wessman S.J.   +12 more
core   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom Minas, Tim Bryant, Takahiro Ogura
openaire   +3 more sources

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

eLife, 2017
The joints of mammals are lined with cartilage, comprised of individual chondrocytes embedded in a specialized extracellular matrix. Chondrocytes experience a complex mechanical environment and respond to changing mechanical loads in order to maintain ...
M. R. Servín-Vences, M. Moroni, G. Lewin, K. Poole   +3 more
semanticscholar   +1 more source

Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]

, 2013
The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van, Georgi, N., Karperien, H.B.J., Leijten, J.C.H., Wu, L.   +4 more
core   +3 more sources

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source